Research Studies

Adults

Treatment-resistant Depression (TRD)

Dr. Jayesh Kamath from UConn Health’s Department of Psychiatry is conducting a clinical research study of an investigational medication for adults with treatment-resistant depression (TRD).

The purpose of this study is to evaluate the effectiveness, safety, and tolerability of the investigational medication when it is used alone in adults with TRD.

You may be eligible to participate if you:

  • Are 18 years of age or older.
  • Have been diagnosed with TRD.
  • Have not adequately responded to at least 2 different antidepressant treatments.

If you are interested, additional eligibility criteria will be assessed by the study doctor or staff. Study participation will last up to 24 weeks.

Qualified participants may receive investigational study medication and some study-required medical care at no cost.
Want to learn more? Call our study coordinator at 860-679-7539.

IRB#: O21-071-2

Enrollment end date: January 2022

Post-Traumatic Stress Disorder (PTSD)

Have you experience or witnessed a traumatic event? Do you have unwanted memories, experience flashbacks, or avoid situations that remind you of the event? If so, you may have a condition called post-traumatic stress disorder (PTSD).

Dr. Jayesh Kamath, from UConn Health’s Department of Psychiatry, is currently enrolling volunteers for a clinical trial looking at an investigational drug for the treatment of PTSD. To pre-qualify for this study, volunteers must be 18 to 65 years of age and have been experiencing PTSD symptoms for at least the past 6 months.

All study-related tests and study drugs will be provided at no cost. Reimbursement for study-related travel and other expenses related to participation may be available.

To learn more, please call 860-679-7539.

IRB#: U20-082-2

Enrollment end date: February 2022

Want to Reduce Your Drinking?

Male and female drinkers needed for a research study. Free study medication for 24-weeks (active drug or inactive placebo) and up to $620 for completing all study visits. Call Dr. Covault’s office at 860-679-7000. All calls are confidential.

Principal Investigator: Jonathan Covault, M.D., Ph.D.

IRB#: 19-147-2

Enrollment end date: 2024

Do You Drink Alcohol? Are You Looking for a Job?

Volunteers needed for a research study. This study looks at how unemployment and alcohol use relate.

Participation involves:

  • 6 interviews over a year.
  • Individual meetings 1 time per week for 12 weeks that may help you find a job.
  • Answering cell phone calls regularly for 12 weeks to monitor alcohol use.

Participants are compensated up to $994 in checks and gift cards over the year for their time and participation. Some participants have chances to win prizes worth $1 to $100.

Call Bill at 860-729-2648 for a confidential screening. Locations throughout Connecticut.

Principal Investigator: Carla Rash, Ph.D., Department of Medicine

IRB#: 15-041-2

Enrollment end date: June 30, 2020

Do You Have HIV/AIDS? Are You Looking for a Job?

Volunteers needed for a research study. This study looks at how to promote employment for individuals living with HIV/AIDS.

Participation involves:

  • 7 interviews over 18 months.
  • Individual meetings 1 time per week for 16 weeks that may help you find a job.

Participants are compensated up to $495 in checks and gift cards for their time and participation. Some participants have chances to win prizes worth $1 to $100.

Call Maria at 203-800-6614 for a confidential screening. Locations throughout Connecticut.

Principal Investigator: Carla Rash, Ph.D., Department of Medicine

IRB#: 18-1782

Enrollment end date: January 31, 2024

Prolonged Exposure-Contingency Management

Are you between the ages of 18 and 25? Have you ever experienced a traumatic event?

Researchers at UConn Health are recruiting volunteers for a study looking at new ways to help people deal with both substance abuse and traumatic events.

Half of participants will receive an experimental treatment to help them with substance abuse and trauma. These participants will have a chance to earn up to $250 in prizes. The other half of participants will receive typical substance abuse treatment. Participants will be randomly assigned to one of the treatments (like a flip of a coin).

  • All study participants will be compensated up to $295 for their time.
  • Participation involves twice weekly meetings for 10 weeks.
  • Participation also involves 3 interviews over 6 months.

Please call Trisha at 860-303-5356 for a confidential screening to see if you are eligible.

Principal Investigator: Kristyn Zajac, Ph.D., Division of Behavioral Cardiovascular Prevention, Calhoun Cardiology Center

IRB#: 16-101-2

Enrollment end date: January 31, 2021

Cognitive Remediation of Cognitive Control in Late-Life Depression

Are you feeling sad or blue? Have you lost interest in things you once enjoyed? Are you concerned about your thinking and memory?

UConn Health study investigates the effects of brain-training treatment on depression. Recruiting men and women over 60 who are currently being treated with antidepressants.

Participation involves:

  • Interviews and evaluations.
  • Testing of thinking and memory.
  • Optional MRI brain scans.
  • No cost for participation.
  • 30 hours of brain-training exercises over 6 weeks. Subjects will be randomly assigned to 1 of 2 cognitive fitness programs.

Payment to participants includes $40 at completion of each of the two assessment visits and $40 at completion of each of two MRI visits for a total of up to $160 for the 14-month study.

To learn more about this study call 860-679-2272.

Principal Investigator: Kevin Manning, Ph.D., Department of Psychiatry

IRB#: 19-240-2

Enrollment end date: August 1, 2023

Families with Children

Adaptation & Resilience in Children Study (ARCS)

ARCS is a large study that seeks to understand how family conflict and other stressors affect the development and behavior of young children. ARCS will help us to identify ways that families and professionals can help to build resilience in young children who have experienced family conflict or violence.

We invite participation from mothers and their 4- to 6-year-old children. We are seeking mothers who have experienced partner conflict and mothers who have not experienced it. Mothers must be 18 years or older and be able to answer study questions in English.

This study involves a visit to our child-friendly laboratory. Mothers answer survey and interview questions and do activities with their children. Kids do computer and puzzle-like activities with one of our team members. In addition, kids “talk” with our puppets about their feelings and experiences. We also use safe, sticky sensors to see how kids react to different emotional facial expressions presented on a computer screen. (Don’t worry! We explain all about the sensors at the time of the visit – mothers decide about it once they see how it all works.)

There is plenty of time for breaks and snacks. The visit usually takes about 3 to 4 hours. Because kids usually finish before mothers do, we entertain them while they wait. Our lab is at 65 Kane Street in West Hartford. This is close to I-84 and bus routes. It is a building over from the Goldroc Diner.

Mothers can earn up to $250 in gift cards to Stop and Shop. Children receive several gifts and prizes, including a UConn Health Kid Scientist t-shirt and backpack, toys, and other prizes.

Travel support is available as needed. If visits occur during mealtime, we will help to coordinate so that you and your child can eat.

Want to find out more? Contact our research coordinator at 860-798-8790 or enrollment specialist Mayra Pino at 860-384-5102.

Want to know if you are eligible? Visit the ARCS U01 Screening Tool to answer our questions and find out if you are eligible in minutes!

End date: May 2024

Parent and Child Emotions Study (PACES)

PACES is a study aimed at understanding how children and families manage their emotions after very stressful life experiences. We are also trying to learn about how parents can help to support their children in overcoming these experiences. PACES will help us to identify ways that professionals can help parents to be better able to support their children and help them to recover after experiencing violence or other traumatic events. We know this can be especially hard when parents have experienced trauma in their lives, too.

We invite participation from children ages 9-12 and a parent, both of whom have experienced a traumatic event. Parents must be 18 years or older, and both children and parents must be able to answer study questions in English.

This study involves a visit to our lab. Parents and children will be asked to answer questionnaires about their experiences, emotions, and behaviors and they will participate in some activities together. While they do these activities, we will monitor parents’ and children’s heart rate and breathing using safe, sticky, sensors. There is also plenty of time for breaks and snacks. Kids usually finish before their parents and can play games with our staff while they wait. We estimate the whole visit will take about 3 hours.

Families will receive $100 in gift cards to Walmart or Target for the visit, and children will also receive a small prize.

Our lab is at 65 Kane Street in West Hartford. This is close to I-84 and bus routes. Our building is next door to the Goldroc Diner.

Want to find out more? Contact the PACES Team at 860-523-6458 or at PACES@uchc.edu.

Want to know if you are eligible? Visit the PACES Screening Tool to answer our questions and find out if you are eligible in minutes!

End date: May 2024

Older Adults

Apathy in Alzheimer’s Disease and Depression


Apathy in Alzheimer’s Disease and Depression

Recruiting men and women ages 65 to 80 who have been diagnosed with mild Alzheimer’s disease or cognitive impairment.

Participation involves:

  • 3 to 5 visits to UConn Health.
  • Interviews and evaluations.
  • Testing of thinking and memory.
  • One-time MRI brain scan.
  • No cost for participation.

Payment to participants includes $100 at completion of the baseline assessment and $100 at completion of the 12-month assessments for a total of up to $200 for the 1-year study.

Principal Investigator: David Steffens, M.D., Department of Psychiatry

IRB#: 19-214-1

Enrollment end date: August 1, 2021