Research Studies

Studies Offering Treatment (Adults)

Want to Reduce Your Drinking?

Male and female drinkers needed for a research study. Free study medication for 24-weeks (active drug or inactive placebo) and up to $620 for completing all study visits. Call Dr. Covault’s office at 860-679-7000. All calls are confidential.

Principal Investigator: Jonathan Covault, M.D., Ph.D.

IRB#: 19-147-2

Enrollment end date: 2024


Alcohol Abuse Outpatient Treatment (IATP2 Project)

Treatment at no charge for male and female heavy drinkers who want to quit drinking. Research studying new behavioral approaches over 2 years.

  • Participants to be randomly assigned to 1 of 3 treatments individual appointments.
  • Confidential.
  • Compensation provided.
  • Must be at least 18 years old.

For information call 860-679-2745 or toll free at 1-866-539-6113.

Principal Investigator: Dr. Mark Litt, Ph.D., Division of Behavioral Sciences and Community Health

IRB #: 16-211-3

Enrollment end date: December 31, 2019


Do You Drink Alcohol? Are You Looking for a Job?

Volunteers needed for a research study. This study looks at how unemployment and alcohol use relate.

Participation involves:

  • 6 interviews over a year.
  • Individual meetings 1 time per week for 12 weeks that may help you find a job.
  • Answering cell phone calls regularly for 12 weeks to monitor alcohol use.

Participants are compensated up to $994 in checks and gift cards over the year for their time and participation. Some participants have chances to win prizes worth $1 to $100.

Call Bill at 860-729-2648 for a confidential screening. Locations throughout Connecticut.

Principal Investigator: Carla Rash, Ph.D., Department of Medicine

IRB#: 15-041-2

Enrollment end date: June 30, 2020


Do You Have HIV/AIDS? Are You Looking for a Job?

Volunteers needed for a research study. This study looks at how to promote employment for individuals living with HIV/AIDS.

Participation involves:

  • 7 interviews over 18 months
  • Individual meetings 1 time per week for 16 weeks that may help you find a job

Participants are compensated up to $495 in checks and gift cards for their time and participation. Some participants have chances to win prizes worth $1 to $100.

Call Maria at 203-800-6614 for a confidential screening. Locations throughout Connecticut.

Principal Investigator: Carla Rash, Ph.D., Department of Medicine

IRB#: 18-1782

Enrollment end date: January 31, 2024


Prolonged Exposure-Contingency Management

Are you between the ages of 18 and 25? Have you ever experienced a traumatic event?

Researchers at UConn Health are recruiting volunteers for a study looking at new ways to help people deal with both substance abuse and traumatic events.

Half of participants will receive an experimental treatment to help them with substance abuse and trauma. These participants will have a chance to earn up to $250 in prizes. The other half of participants will receive typical substance abuse treatment. Participants will be randomly assigned to one of the treatments (like a flip of a coin).

  • All study participants will be compensated up to $295 for their time.
  • Participation involves twice weekly meetings for 10 weeks.
  • Participation also involves 3 interviews over 6 months.

Please call Trisha at 860-303-5356 for a confidential screening to see if you are eligible.

Principal Investigator: Kristyn Zajac, Ph.D., Division of Behavioral Cardiovascular Prevention, Calhoun Cardiology Center

IRB#: 16-101-2

Enrollment end date: January 31, 2021


Video Directly Observed Therapy (VDOT) to Improve Medication Adherence Among Depression Patients

Drs. Riddhi Doshi, Jayesh Kamath, and Robert H. Aseltine Jr., along with UConn Health’s Center for Population Health and in collaboration with the Department of Psychiatry are conducting this research study. The purpose of this research study is to test whether using a smartphone application called SureAdhere improves how regularly patients take their depression medicine and depression symptoms. In order to be eligible to participate in this study, you must be 18 years of age or older, proficient in English (speaking, reading, and writing), have a clinical diagnosis of depression, and currently on prescription medication for depression. You must own a mobile phone with an active phone plan capable of receiving text messages. Participation will last approximately 3 months. Participants who complete all required actions will receive $100.

To learn more about the study, please contact our research staff at 860-679-7539 or 860-679-8848.

Principal Investigator: Riddhi Doshi, Ph.D.

IRB#: 19-136-2


Cognitive Remediation of Cognitive Control in Late-Life Depression

Are you feeling sad or blue? Have you lost interest in things you once enjoyed? Are you concerned about your thinking and memory?

UConn Health study investigates the effects of brain-training treatment on depression. Recruiting men and women over 60 who are currently being treated with antidepressants.

Participation involves:

  • Interviews and evaluations.
  • Testing of thinking and memory.
  • Optional MRI brain scans.
  • No cost for participation.
  • 30 hours of brain-training exercises over 6 weeks. Subjects will be randomly assigned to 1 of 2 cognitive fitness programs.

Payment to participants includes $40 at completion of each of the two assessment visits and $40 at completion of each of two MRI visits for a total of up to $160 for the 14-month study.

To learn more about this study call 860-679-2272.

Principal Investigator: Kevin Manning, Ph.D., Department of Psychiatry

IRB#: 19-240-2

Enrollment end date: August 1, 2023

Studies Offering Treatment (Children)

Worried About How Much Your Child Plays Video Games?

Volunteer for a research study looking at ways to help reduce gaming.

  • All participants receive assessment and referrals and half receive 6 weekly therapy sessions
  • All participants complete 4 interviews over 6 months
  • Children can participate with their parents, and all participants receive up to $120 for their time

Call Melanie at 413-530-3383 for a confidential screening to see if you are eligible.

Principal Investigator: Kristyn Zajac, Ph.D., Department of Medicine

IRB#: 16-114-3

Enrollment end date: March 31, 2020


Is Your Teen Very Nervous, Anxious, or Sad?

Our research study may be able to help.

We are inviting families with an adolescent (12-18 years old), whose worry, stress, or sadness makes life harder for them, to participate in COMET (Community Study of Outcome Monitoring for Emotional Disorders in Teens). COMET is a research study taking place in Connecticut, Massachusetts, and Florida community clinics that evaluates treatments for teens with anxiety and depression.

What is involved in participating in COMET?

  • Meet with study staff for a free evaluation to see if this study is right for you.
  • If eligible, meet with your community clinician for 16 weeks.
  • There is no medication involved in this study.
  • Your child will receive one of three types of a talk therapy.
  • Meet with study staff 3 more times during and after the intervention so we can see if your child’s anxiety or depression has improved.
  • Families may earn up to $220 in gift cards for participating

For more information, please contact COMET Study Team at 860-523-3779, COMET@uchc.edu.

Principal Investigator: Golda Ginsburg, Ph.D., Department of Psychiatry

IRB Number: 15-157-6

Enrollment end date: November 15, 2019

Studies of Learning and Memory Problems (Older Adults)

Apathy in Alzheimer’s Disease and Depression

Recruiting men and women ages 65 to 80 who have been diagnosed with mild Alzheimer’s disease or cognitive impairment.

Participation involves:

  • 3 to 5 visits to UConn Health.
  • Interviews and evaluations.
  • Testing of thinking and memory.
  • One-time MRI brain scan.
  • No cost for participation.

Payment to participants includes $100 at completion of the baseline assessment and $100 at completion of the 12-month assessments for a total of up to $200 for the 1-year study.

Principal Investigator: David Steffens, M.D., Department of Psychiatry

IRB#: 19-214-1

Enrollment end date: August 1, 2021