Cognitive Remediation of Executive Deficits in Geriatric Depression (Neuroplasticity)

This study is testing a computer-based program designed to improve mood, memory, and cognitive function in older adults who suffer from depression.

Recruiting adults ages 55 and older who:

• Have symptoms of depression.
• Have tried antidepressants in the past and felt like they never got them to a non-depressed state.
• Have not been diagnosed with dementia or mild cognitive impairment.
• Are able to read and write in English.

Participation involves:

• Treatment: Over four weeks, participants will complete 32 hours of a computer-based program at home, which involves playing “brain games” on a tablet the study team provides. Participants will be randomly assigned to one of two programs designed to enhance brain activity.
• Assessments: Baseline, four weekly intervention assessments, and four follow-up assessments to measure mood and thinking abilities. Most take place at UConn Health in Farmington, CT.
• Cost & Compensation: Participation is free, with up to $275 compensation.

Payment to participants includes: $50 for the baseline evaluation, $25 for each select weekly assessments (weeks 1, 2, and 3), $50 for week 4 assessments, $50 for 3-month post-intervention assessments, and $50 for 1-year post-intervention assessments for a total of up to $275 for the 14-month research study.

Principal Investigator: David Steffens, M.D., Department of Psychiatry

IRB Number: 022-008-1

Enrollment end date: April 30, 2026