Welcome to the Vargas-Rodriguez Lab
Our research seeks to understand the underlying mechanisms that control the translation of mRNAs into proteins and how dysregulation of protein synthesis contributes to disease. We focus on transfer RNAs (tRNAs) and aminoacyl-tRNA synthetases (aaRSs), essential and universally conserved translation factors. We apply diverse methods to investigate how aaRSs and tRNAs mediate the regulation of protein synthesis. By leveraging this knowledge, we aim to identify pathways for developing new therapeutics. For more details, visit our Research page.
In addition to our commitment to rigorous and innovative research, we strive to create a collegial and inclusive environment wherein our team trainees are supported and empowered to accomplish their career goals.
Latest Publications
- Efficient suppression of premature termination codons with alanine by engineered chimeric pyrrolysine tRNAs
- Coexisting bacterial aminoacyl-tRNA synthetase paralogs exhibit distinct phylogenetic backgrounds and functional compatibility with Escherichia coli
- Engineered mRNA–ribosome fusions for facile biosynthesis of selenoproteins