Welcome to the Vargas-Rodriguez Lab
Our research seeks to understand the underlying mechanisms that control the translation of mRNAs into proteins and how dysregulation of protein synthesis contributes to disease. We focus on transfer RNAs (tRNAs) and aminoacyl-tRNA synthetases (aaRSs), essential and universally conserved translation factors. We apply diverse methods to investigate how aaRSs and tRNAs mediate the regulation of protein synthesis. By leveraging this knowledge, we aim to identify pathways for developing new therapeutics. For more details, visit our Research page.
In addition to our commitment to rigorous and innovative research, we strive to create a collegial and inclusive environment wherein our team trainees are supported and empowered to accomplish their career goals.
Latest Publications
- Mechanistic and evolutionary insights into a family of aminoacyl-tRNA deacylases that protects against canavanine toxicity
- An engineered glutamic acid tRNA for efficient suppression of pathogenic nonsense mutations
- Efficient suppression of premature termination codons with alanine by engineered chimeric pyrrolysine tRNAs