In our recent publication in the FASEB journal, we conducted a screen to identify novel C1QL3 binding partners, which revealed members of the neuronal pentraxin family (NPTX1 and NPTXR). The conclusion was confirmed using quantitative biochemical methods (surface plasmon resonance) to measure the binding affinity. We predict that the neuronal pentraxins are a component in a C1QL-mediated trans-synaptic adhesion complex.