The Hurley laboratory examines molecular mechanisms by which members of the fibroblast growth factor (FGFs) and fibroblast growth factor receptor (FGFR) families, regulate, bone remodeling and disorders of bone. Specifically, FGF2 global and conditional knockout and FGF2 isoform transgenic mice are utilized in loss and gain of function experiments to elucidate the role of FGF2 in disorders of bone including osteoporosis, fracture healing, as well as rickets and osteomalacia due to phosphate wasting.
Ablation of low-molecular-weight FGF2 isoform accelerates murine osteoarthritis while loss of high-molecular-weight FGF2 isoforms offers protection.
Burt PM, Xiao L, Doetschman T, Hurley MM. J Cell Physiol. 2019 Apr;234(4):4418-4431. doi: 10.1002/jcp.27230. Epub 2018 Aug 25.