The Hurley laboratory examines molecular mechanisms by which members of the fibroblast growth factor (FGFs) and fibroblast growth factor receptor (FGFR) families, regulate, bone remodeling and disorders of bone. Specifically, FGF2 global and conditional knockout and FGF2 isoform transgenic mice are utilized in loss and gain of function experiments to elucidate the role of FGF2 in disorders of bone including osteoporosis, fracture healing, as well as rickets and osteomalacia due to phosphate wasting.
Recent Publications
Fibroblast Growth Factor 23 Neutralizing Antibody Ameliorates Abnormal Renal Phosphate Handling in Sickle Cell Disease Mice. Xiao L, Clarke K, Hurley MM.Endocrinology. 2023 Nov 2;164(12):bqad173. doi: 10.1210/endocr/bqad173.PMID: 37972265
Fibroblast Growth Factor 2 High Molecular Weight Isoforms in Dentoalveolar Mineralization. Millington G, Joseph J, Xiao L, Vijaykumar A, Mina M, Hurley MM.Calcif Tissue Int. 2022 Jan;110(1):93-103. doi: 10.1007/s00223-021-00888-3. Epub 2021 Jul 10.PMID: 34245331
FGF receptor inhibitor BGJ398 partially rescues osteoarthritis-like phenotype in older high molecular weight FGF2 transgenic mice via multiple mechanisms. Hurley MM, Coffin JD, Doetschman T, Valera C, Clarke K, Xiao L.Sci Rep. 2022 Sep 24;12(1):15968. doi: 10.1038/s41598-022-20269-6.PMID: 36153352
Gait disturbances and muscle dysfunction in fibroblast growth factor 2 knockout mice. Homer-Bouthiette C, Xiao L, Hurley MM.Sci Rep. 2021 May 26;11(1):11005. doi: 10.1038/s41598-021-90565-0.PMID: 34040128
Endogenous FGF-2 levels impact FGF-2/BMP-2 growth factor delivery dosing in aged murine calvarial bone defects. Kuhn LT, Peng T, Gronowicz G, Hurley MM.J Biomed Mater Res A. 2021 Dec;109(12):2545-2555. doi: 10.1002/jbm.a.37249. Epub 2021 Jun 26.PMID: 34173706
Inhibition of FGFR Signaling Partially Rescues Osteoarthritis in Mice Overexpressing High Molecular Weight FGF2 Isoforms. Xiao L, Williams D, Hurley MM.Endocrinology. 2020 Jan 1;161(1):bqz016. doi: 10.1210/endocr/bqz016.PMID: 31901095
Ablation of low-molecular-weight FGF2 isoform accelerates murine osteoarthritis while loss of high-molecular-weight FGF2 isoforms offers protection.
Burt PM, Xiao L, Doetschman T, Hurley MM. J Cell Physiol. 2019 Apr;234(4):4418-4431. doi: 10.1002/jcp.27230. Epub 2018 Aug 25.