263 Farmington Avenue
Farmington, CT 06030
My research concerns mechanisms that regulate hematopoietic stem cells, and investigates how in conditions where more blood is needed, hormonal signals stimulate the proliferation and mobilization of these stem cells to make more blood cells. In a recent paper (J. Clinical Investigation, 2017, 127: 3392-2401), we demonstrated that two endogenous estrogen receptor ligands, estradiol and 27-hydroxycholesterol, differentially induce proliferation and mobilization of hematopoietic stem cells, respectively. This hormonal regulation is particularly important during pregnancy when maternal blood expands rapidly (figure adopted from Frontiers in Endocrinology, 2019, 10:204), and can lead to new strategies to promote hematopoietic regeneration and to enhance mobilization of stem cells into the bloodstream for transplantation. An additional focus of my research is to generate hematopoietic stem cells from human induced pluripotent stem cells by mimicking their developmental process.
The Roles of Cholesterol and Its Metabolites in Normal and Malignant Hematopoiesis. Front Endocrinol (Lausanne). 2019;10:204. doi: 10.3389/fendo.2019.00204. eCollection 2019. Review. PubMed PMID: 31001203; PubMed Central PMCID: PMC6454151.
Generation of Hematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells. Methods Mol Biol. 2019;2048:245-257. doi: 10.1007/978-1-4939-9728-2_19. PubMed PMID: 31396942.