Terasaki Lab

Current Members

Valentina Baena

Valentina Baena

Postdoctoral Fellow
Phone: 860-679-8582
Email: baena@uchc.edu

My research is focused on analyzing the intercellular interactions of somatic cells within the mouse ovarian follicle and the oocyte-somatic cell interactions. I mainly study this by translating serial section electron micrographs to three-dimensional models.

Poster About Current Research

Baena, V., and Terasaki, M. Intercellular communication in the mouse ovarian follicle analyzed by serial section electron microscopy; American Society for Cell Biology/ European Molecular Biology Organization Meeting. December 2-6, 2017 in Philiadelphia, PA, USA.

Recent Publications

Baena, V., Owen, C.M., Uliasz, T.F., Lowther, K.M., Yee, S.-P., Terasaki, M., Egbert, J., Jaffe, L.A., 2020. Cellular heterogeneity of the LH receptor and its significance for cyclic GMP signaling in mouse preovulatory follicles. bioRxiv 2020.02.06.937995.

Baena, V., Schalek, R.L., Lichtman, J.W., Terasaki, M., 2019. Chapter 3 - Serial-section electron microscopy using automated tape-collecting ultramicrotome (ATUM), in: Müller-Reichert, T., Pigino, G. (Eds.), Methods in Cell Biology, Three-Dimensional Electron Microscopy. Academic Press, pp. 41–67.

Baena, V., Terasaki, M., 2019. Three-dimensional organization of transzonal projections and other cytoplasmic extensions in the mouse ovarian follicle. Scientific Reports 9, 1262.

Publications

Melanie Fisher

Melanie Fisher

Research Associate I
Phone:860-679-8582
Email: fisher@uchc.edu

I am a Research Associate in Mark Terasaki’s lab. My primary project involves using serial section SEM to study cell-cell and cell-matrix interactions in articular cartilage and between articular cartilage and subchondral bone. I also assist with other projects in the lab as needed and with general lab responsibilities.

Rachael Norris

Rachael Norris

Postdoctoral Fellow
Phone: 860-679-8582
Email: norris@uchc.edu

Gap junctions are specialized connections that effectively join two cells together and allow for the passage of small components between cells such as ions or metabolites. Gap junctions are present between nearly all the cells of our body, and affect how most of our organs work. Invertebrate animals also rely on gap junctions for many processes. When gap junctions are no longer needed to connect cells, they get internalized into one of the two cells they connect, forming a double-membrane vesicle. I am interested in whether gap junction internalization is biased in one direction or another and whether internalized gap junctions have functions in the cytoplasm before they get degraded. One way am investigating these questions is by combining serial section electron microscopy and immuno-labeling of proteins.

Poster About Current Research

Norris, R.P., Baena, V., and Terasaki, M. Serial section immunogold electron microscopy of phosphorylated Connexin 43 in ovarian granulosa. UConn Health Department of Cell Biology Retreat, 2017, Apr 18. West Hartford, CT.

Recent Publications

Anteroposterior axis patterning by early canonical Wnt signaling during hemichordate development. Darras S, Fritzenwanker JH, Uhlinger KR, Farrelly E, Pani AM, Hurley IA, Norris RP, Osovitz M, Terasaki M, Wu M, Aronowicz J, Kirschner M, Gerhart JC, Lowe CJ. PLoS Biol. 2018 Jan 16;16(1):e2003698. doi: 10.1371/journal.pbio.2003698. eCollection 2018 Jan.

Localization of phosphorylated connexin 43 using serial section immunogold electron microscopy. Norris RP, Baena V, Terasaki M. J Cell Sci. 2017 Apr 1;130(7):1333-1340. doi: 10.1242/jcs.198408. Epub 2017 Feb 15.

Publications

Micki Furushi

Miki Furusho

Research Associate I
Email: mfurusho@uchc.edu

I am interested in the 3D ultrastructure of neurons and glia. Now I am studying the ultra-structure of the axon initial segment and oligodendrocyte progenitor cell.