Opportunities for Students and Postdoctoral Fellows

A research position is now available for a student, postdoctoral fellow or technical assistant.

This research position is funded by a recent NIH grant exploring genetically encoded indicators of neuronal functions. 

Experiments will be based on breeding, genotyping, electroporation, patch electrode recordings, calcium imaging, voltage-sensitive dye recordings and computer simulations (modeling). 

Highly motivated, completely-devoted-to-science and hardworking individuals are encouraged to apply by sending their letter of inquiry to Srdjan Antic.

Filtering of action potentials in the apical tuft.

 

Filtering of action potentials in the apical tuft. D1) Microphotograph of a layer 5 pyramidal neuron in the rat prefrontal cortex. The neuron is filled with two fluorescent dyes (AlexaFluor 594 and Oregon Green Bapta-1). D2) Three action potentials were evoked by somatic current injections. Optical imaging of action potential-induced dendritic calcium transients was performed simultaneously from 7 locations (1 - 7) marked in D1. Bottom trace represents whole-cell recording from the cell body (soma). Three action potentials back propagate into the apical tuft dendrites and induce calcium transients. At each branch point (BP-2 to BP-4), one late AP is lost. Note that 3 spikes start from location number 1. The third spike is lost after passing through branch point BP-2. Two spikes start from location number 3. The second spike is lost after passing through branch point BP-4, so that only the first spike arrives in locations numbers 5, 6 and 7. Published in Neurophotonics.