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Publications

Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance
Singh, N., Das, B., Zhou, J., Hu, X., & Yan, R. (2022). Science advances, 8(29), eabo3610.

BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1
Singh, N., Benoit, M. R., Zhou, J., Das, B., Davila-Velderrain, J., Kellis, M., Tsai, L. H., Hu, X., & Yan, R. (2022). Science advances, 8(24), eabo1286.

Metabotropic Glutamate Receptors in Alzheimer's Disease Synaptic Dysfunction: Therapeutic Opportunities and Hope for the Future
Srivastava, A., Das, B., Yao, A. Y., & Yan, R. (2020). Journal of Alzheimer's disease : JAD, 78(4), 1345–1361.

Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction
Fan, Q., He, W., Gayen, M., Benoit, M. R., Luo, X., Hu, X., & Yan, R. (2020). The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(5), 1133–1144.

The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer's amyloid pathology
Fan, Q., Gayen, M., Singh, N., Gao, F., He, W., Hu, X., Tsai, L. H., & Yan, R. (2019). The Journal of experimental medicine, 216(8), 1891–1903.

CX3CL1 intracellular domain and adult neurogenesis
Benoit, M. R., Gayen, M., & Yan, R. (2019). CX3CL1 intracellular domain and adult neurogenesis. Aging, 11(23), 10783–10785.

A Close Look at BACE1 Inhibitors for Alzheimer's Disease Treatment
Das, B., & Yan, R. (2019). CNS drugs, 33(3), 251–263.

Sequential formation of different layers of dystrophic neurites in Alzheimer's brains.
Sharoar, M. G., Hu, X., Ma, X. M., Zhu, X., & Yan, R. (2019). Molecular psychiatry, 24(9), 1369–1382.