Leptospirosis Research

Publications

Selected Leptospirosis Publications

  • Bettin EB, Grassmann AA, Dellagostin OA, Gogarten JP, Caimano MJ. Leptospira interrogans encodes a canonical BamA and three novel noNterm Omp85 outer membrane protein paralogs. Sci Rep. 2024;14(1):19958. PMID: 39198480; PMCID: PMC11358297. PubMed

  • Maia MAC, Bettin EB, Barbosa LN, et al. Challenges for the development of a universal vaccine against leptospirosis revealed by the evaluation of 22 vaccine candidates. Front Cell Infect Microbiol. 2022;12:940966. PMID: 36275031; PMCID: PMC9586249. PubMed

  • Bettin EB, Dorneles J, Hecktheuer AS, et al. TonB-dependent receptor epitopes expressed in M. bovis BCG induced significant protection in the hamster model of leptospirosis. Appl Microbiol Biotechnol. 2022;106(1):173–184. PMID: 34893930; PMCID: PMC8664668. PubMed

  • Grassmann AA, Zavala-Alvarado C, Bettin EB, et al. The FUR-like regulators PerRA and PerRB integrate a complex regulatory network that promotes mammalian host-adaptation and virulence of Leptospira interrogans.PLoS Pathog. 2021;17(12):e1009078. PMID: 34855918; PMCID: PMC8638967. PubMed

  • Grassmann AA, Caimano MJ. Cultivation of Leptospira interrogans Within Rat Peritoneal Dialysis Membrane Chambers. Methods Mol Biol. 2020;2134:229–242. PMID: 32632874. PubMed

  • Nally JE, Grassmann AA, Planchon S, et al. Pathogenic leptospires modulate protein expression and post-translational modifications in response to mammalian host signals. Front Cell Infect Microbiol. 2017;7:362. PMID: 28848720; PMCID: PMC5553009. PubMed

  • Grassmann AA, Kremer FS, Dos Santos JC, et al. Discovery of novel leptospirosis vaccine candidates using reverse and structural vaccinology. Front Immunol. 2017;8:463. PMID: 28496441; PMCID: PMC5406399. PubMed

  • Grassmann AA, Souza JD, McBride AJA. A universal vaccine against leptospirosis: Are we going in the right direction? Front Immunol. 2017;8:256. PMID: 28337203; PMCID: PMC5343615. PubMed

  • Dellagostin OA, Grassmann AA, Rizzi C, et al. Reverse vaccinology: An approach for identifying leptospiral vaccine candidates. Int J Mol Sci. 2017;18(1):158. PMID: 28098813; PMCID: PMC5297791. PubMed

  • Caimano MJ, Sivasankaran SK, Allard A, et al. A model system for studying the transcriptomic and physiological changes associated with mammalian host-adaptation by Leptospira interrogans serovar Copenhageni. PLoS Pathog. 2014;10(3):e1004004. PMID: 24626166; PMCID: PMC3953431. PubMed