The Oguro laboratory investigates mechanisms that regulate blood-forming hematopoietic stem cell (HSC) development, self-renewal, and malignant transformation using mouse models, patient samples, and human induced pluripotent stem cells (hiPSCs). Our long-term research goal is to elucidate the molecular and cellular mechanisms of HSC function and translate our findings into therapies for diseases caused by insufficient hematopoiesis or hematologic malignancies.