Andrew Arnold, M.D.
Pathogenesis of parathyroid and other endocrine tumors, and role of the cyclin D1 oncogene in neoplasia, including breast cancer.
Christopher D. Heinen, Ph.D.
The molecular biology of colorectal cancer. Understanding the functions of the DNA mismatch repair system affected during tumorigenesis using biochemical, cell culture and human organoid models.
Anne Delany, Ph.D.
Study of non-collagen matrix proteins in normal bone remodeling and the impact of microenvironment on tumor development and metastasis.
Marc Hansen, Ph.D.
Pathogenesis of bone tumors, the role of tumor suppressor genes in neoplasia and development. Genetics of Paget's disease of bone.
Masako Nakanishi, Ph.D.
Pathogenesis of gastrointestinal inflammation and cancer, mouse tumor models, the role of lipid metabolism, microbiome, nutritional intervention.
Abhijit Rath, Ph.D.
Modeling Lynch syndrome (LS) associated DNA mismatch repair gene variants in human embryonic stem cells using CRISPR-Cas gene editing. Functional testing of engineered cell lines to detect deleterious impact on protein function for better stratification of LS patients. Improving throughput of the reverse genetic approaches for large scale studies. Exploring novel methodologies to improve homology directed repair outcomes for CRISPR-Cas induced DNA double-strand breaks.
Suzy V. Torti, Ph.D.
Our laboratory is interested in the molecular and cell biology of iron metabolism in breast cancer and other malignancies. We are also investigating the use of nanomaterials as anticancer agents.