NMR Data Acquisition and Processing
- Rapid multidimensional NMR using non-uniform sampling
- Non-Fourier spectral analysis, especially maximum entropy reconstruction
Rowland NMR Toolkit Collaborators
- Alan Stern (Rowland Institute at Harvard)
- Gerhard Wagner (Harvard Medical School)
- Mehdi Mobli (University of Queensland)
- Mark Maciejewski (UConn Health)
- Michael Gryk (UConn Health)
- Adam Schuyler (UConn Health)
- Jay Vyas (UConn Health)
- Jonathan Helmus (UConn Health)
- Matthew Fenwick (UConn Health)
Protein Structure Refinement
- Coarse-grained modeling
- MoSART: Molecular Structure Analysis and Refinement Tool
Collaborator:
- Alan Stern (Rowland Institute at Harvard)
Prolactin: Structure, Dynamics, Stability, and Function
- Promotes lactation during pregnancy; highly angiogenic, mytogenic for T cells
- Implicated in some breast cancers
- NMR relaxation studies of allosteric binding
Collaborators:
- Janus Vang (UConn Health)
- Birthe Kragelund (University of Copenhagen)
- Dmitry M. Korzhnev (UConn Health)
PfPMT: Structure, Dynamics, Stability, and Function
- Essential methyltransferase from Plasmodium palcifarum, the causative agent of malaria
- Identify inhibitors
Collaborators:
- Choukri Ben Mamoun (Yale Medical School)
- Iulian Rujan (UConn Health)
- Irina Bezsonova (UConn Health)
Osmometry for Probing Water-Biomolecule Interactions
- 2nd virial coefficients, hydrophobic effect, preferential interactions
- Design and construction of a high precision, high dynamic range instrument
Collaborators:
- Alan Stern (Rowland Institute at Harvard)
- Winfred Hill (Rowland Institute at Harvard)