| Study type/ Setting | Methods | Outcomes | Recommendations | Source | 
| Retrospective, cohort study
 
 
 Setting: Primary Care 
 
  | 
- The aims of this study were to determine prevalence and predictive
 factors of initial medication nonadherence (IMNA)- defined as not obtaining a medication the first time it is prescribed in the Catalan health system (Spain) - 1.6 million patients with 2.9 million prescriptions were included  | 
- Total IMNA prevalence was
 17.6% of prescriptions - Predictors of IMNA are younger age, American nationality, having pain-related or mental disorder and being treated by a substitute/resident general practitioner in a resident training center.  | 
- Attempts to strengthen trust in resident general practitioners and improve motivation to initiate a needed medication in the general young and older immigrant population should be addressed in Catalan PC. | Aznar-Lou I et al. (2017) | 
| Aznar-Lou I, Fernández A, Gil-Girbau M, et al. Initial medication non-adherence: prevalence and predictive factors in a cohort of 1.6 million primary care patients. British Journal of Clinical Pharmacology. 2017;83(6):1328-1340. doi:10.1111/bcp.13215  | 
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