Publications

  1. Afzal J, Liu Y, Du W, Suhail Y, Zong P, Feng J, Ajeti V, Sayyad WA, Nikolaus J, Yankova M, Deymier AC, Yue L, Kshitiz. Cardiac ultrastructure inspired matrix induces advanced metabolic and functional maturation of differentiated human cardiomyocytes. Cell Rep. 2022 Jul 26;40(4):111146. doi: 10.1016/j.celrep.2022.111146. PubMed PMID: 35905711.
  2. Phoenix KN, Yue Z, Yue L, Cronin CG, Liang BT, Hoeppner LH, Claffey KP. PLC (Phospholipase C) β2 Promotes VEGF (Vascular Endothelial Growth Factor)-Induced Vascular Permeability. Arterioscler Thromb Vasc Biol. 2022 Jul 21;:101161ATVBAHA122317645. doi: 10.1161/ATVBAHA.122.317645. [Epub ahead of print] PubMed PMID: 35861069.
  3. Zong P, Feng J, Yue Z, Li Y, Wu G, Sun B, He Y, Miller B, Yu AS, Su Z, Xie J, Mori Y, Hao B, Yue L. Functional coupling of TRPM2 and extrasynaptic NMDARs exacerbates excitotoxicity in ischemic brain injury. Neuron. 2022 Jun 15;110(12):1944-1958.e8. doi: 10.1016/j.neuron.2022.03.021. Epub 2022 Apr 13. PubMed PMID: 35421327; PubMed Central PMCID: PMC9233078.
  4. Zong P, Feng J, Yue Z, Yu AS, Vacher J, Jellison ER, Miller B, Mori Y, Yue L. TRPM2 deficiency in mice protects against atherosclerosis by inhibiting TRPM2-CD36 inflammatory axis in macrophages. Nat Cardiovasc Res. 2022 Apr;1(4):344-360. doi: 10.1038/s44161-022-00027-7. Epub 2022 Mar 28. PubMed PMID: 35445217; PubMed Central PMCID: PMC9015693.
  5. Zong P, Lin Q, Feng J, Yue L. A Systemic Review of the Integral Role of TRPM2 in Ischemic Stroke: From Upstream Risk Factors to Ultimate Neuronal Death. Cells. 2022 Jan 31;11(3). doi: 10.3390/cells11030491. Review. PubMed PMID: 35159300; PubMed Central PMCID: PMC8834171.
  6. Bai Z, Feng J, Franken GAC, Al'Saadi N, Cai N, Yu AS, Lou L, Komiya Y, Hoenderop JGJ, de Baaij JHF, Yue L, Runnels LW. CNNM proteins selectively bind to the TRPM7 channel to stimulate divalent cation entry into cells. PLoS Biol. 2021 Dec;19(12):e3001496. doi: 10.1371/journal.pbio.3001496. eCollection 2021 Dec. PubMed PMID: 34928937; PubMed Central PMCID: PMC8726484.
  7. Yue L, Xu H. TRP channels in health and disease at a glance. J Cell Sci. 2021 Jul 1;134(13). doi: 10.1242/jcs.258372. Epub 2021 Jul 13. PubMed PMID: 34254641; PubMed Central PMCID: PMC8358089.
  8. Zong P, Feng J, Yue Z, Li Y, Wu G, Sun B, He Y, Miller B, Yu AS, Su Z, Xie J, Mori Y, Hao B, Yue L. Functional coupling of TRPM2 and extrasynaptic NMDARs exacerbates excitotoxicity in ischemic brain injury. Neuron. 2022 Apr 11:S0896-6273(22)00257-4. doi: 10.1016/j.neuron.2022.03.021. Online ahead of print. PMID: 35421327
  9. Zong, P., Feng, J., Yue, Z. et al. TRPM2 deficiency in mice protects against atherosclerosis by inhibiting TRPM2–CD36 inflammatory axis in macrophages. Nat Cardiovasc Res 1, 344–360 (2022). https://doi.org/10.1038/s44161-022-00027-7
  10. Zong P, Lin Q, Feng J, Yue L. A Systemic Review of the Integral Role of TRPM2 in Ischemic Stroke: From Upstream Risk Factors to Ultimate Neuronal Death. Cells. 2022 Jan 31;11(3):491. doi: 10.3390/cells11030491. PMID: 35159300
  11. Bai Z, Feng J, Franken GAC, Al'Saadi N, Cai N, Yu AS, Lou L, Komiya Y, Hoenderop JGJ, de Baaij JHF, Yue L, Runnels LW. CNNM proteins selectively bind to the TRPM7 channel to stimulate divalent cation entry into cells. PLoS Biol. 2021 Dec 20;19(12):e3001496. doi: 10.1371/journal.pbio.3001496. eCollection 2021 Dec. PMID: 34928937 Free PMC article.
  12. Yue L, Xu H. TRP channels in health and disease at a glance. J Cell Sci. 2021 Jul 1;134(13):jcs258372. doi: 10.1242/jcs.258372. Epub 2021 Jul 13. PMID: 34254641
  13. Bare DJ, Yue L, Ai X. A special issue on calcium dynamics of the heart: remodeling of ion channels and regulatory pathways. Pflugers Arch. 2021 Mar;473(3):313-316. doi: 10.1007/s00424-021-02532-3. Epub 2021 Mar 5. PMID: 33666746
  14. Feng J, Zong P, Yan J, Yue Z, Li X, Smith C, Ai X, Yue L. Upregulation of transient receptor potential melastatin 4 (TRPM4) in ventricular fibroblasts from heart failure patients. Pflugers Arch. 2021 Mar;473(3):521-531. doi: 10.1007/s00424-021-02525-2. Epub 2021 Feb 16. PMID: 33594499
  15. Hiraishi K, Kurahara LH, Feng J, Yamamura A, Cui Y, Yahiro E, Yokomise H, Go T, Ishikawa K, Yokota N, Fujiwara A, Onitsuka M, Abe K, Ohga S, Satoh T, Okada Y, Yue L, Inoue R, Hirano K. Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension. Transl Res. 2021 Jul;233:127-143. doi: 10.1016/j.trsl.2021.03.004. Epub 2021 Mar 7. PMID: 33691194. Translational Research 233, 127-143
  16. Park JW, Yan L, Stoddard C, Wang X, Yue Z, Crandall L, Robinson T, Chang Y, Denton K, Li E, Jiang B, Zhang Z, Martins-Taylor K, Yee SP, Nie H, Gu F, Si W, Xie T, Yue L, Xu RH. Recapitulating and Correcting Marfan Syndrome in a Cellular Model. Int J Biol Sci. 2017 Apr 10;13(5):588-603. doi: 10.7150/ijbs.19517. eCollection 2017.  PMID: 28539832
  17. Yu H, Kistler A, Faridi MH, Meyer JO, Tryniszewska B, Mehta D, Yue L, Dryer S, Reiser J. Synaptopodin Limits TRPC6 Podocyte Surface Expression and Attenuates Proteinuria. J Am Soc Nephrol. 2016 Nov;27(11):3308-3319. Epub 2016 Mar 28.
  18. Zeng H, Guo M, Zhou T, Tan L, Chong CN, Zhang T, Dong X, Xiang JZ, Yu AS, Yue L, Qi Q, Evans T, Graumann J, Chen S. An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery.  Cell Stem Cell. 2016 Sep 1;19(3):326-40. doi: 10.1016/j.stem.2016.07.002. Epub 2016 Aug 11.
  19. Tsujikawa H, Yu AS, Xie J, Yue Z, Yang W, He Y, Yue L. Identification of key amino acid residues responsible for internal and external pH sensitivity of Orai1/STIM1 channels.  Sci Rep. 2015 Nov 18;5:16747. doi: 10.1038/srep16747.
  20. Cagavi E, Bartulos O, Suh CY, Sun B, Yue Z, Jiang Z, Yue L, Qyang Y. Functional cardiomyocytes derived from Isl1 cardiac progenitors via Bmp4 stimulation.  PLoS One. 2014 Dec 18;9(12):e110752. doi: 10.1371/journal.pone.0110752. eCollection 2014.
  21. Yue Z, Xie J, Yu AS, Stock J, Du J, Yue L. Role of TRP channels in the cardiovascular system.  Am J Physiol Heart Circ Physiol. 2015 Feb 1;308(3):H157-82. doi: 10.1152/ajpheart.00457.2014. Epub 2014 Nov 21. Review.
  22. Yue Z, Zhang Y, Xie J, Jiang J, Yue L. Transient receptor potential (TRP) channels and cardiac fibrosis. Curr Top Med Chem. 2013;13(3):270-82. Invited Review.
  23. Qin X, Yue Z, Sun B, Yang W, Xie J, Ni E, Feng Y, Mahmood R, Zhang Y, Yue L. Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels.   Br J Pharmacol. 2013 Mar;168(6):1294-312. doi: 10.1111/bph.12012.
  24. Ge X, Ren Y, Bartulos O, Lee MY, Yue Z, Kim KY, Li W, Amos PJ, Bozkulak EC, Iyer A, Zheng W, Zhao H, Martin KA, Kotton DN, Tellides G, Park IH, Yue L, Qyang Y. Modeling supravalvular aortic stenosis syndrome with human induced pluripotent stem cells.   Circulation. 2012 Oct 2;126(14):1695-704. doi:10.1161/CIRCULATIONAHA. 112.116996. Epub 2012 Aug 22.
  25. Lee MY, Sun B, Schliffke S, Yue Z, Ye M, Paavola J, Bozkulak EC, Amos PJ, Ren Y, Ju R, Jung YW, Ge X, Yue L, Ehrlich BE, Qyang Y. Derivation of functional ventricular cardiomyocytes using endogenous promoter sequence from murine embryonic stem cells. Stem Cell Res. 2012 Jan;8(1):49-57. Epub 2011 Aug 22.
  26. Xie J, Sun B, Du J, Chen H, Overton J, Yang W, Runnels L, Yue L. Phosphatidylinositol 4,5-bisphosphate (PIP2) controls magnesium gatekeeper TRPM6 activity. Scientific Report. 2011; 1:146. Epub 2011 Nov 9.
  27. Estes M, Sacco R, Al-Khatib S, Ellinor P, Bezanson J, Alonso A, Antzelevitch C, Brockman R, Chen P-S, Chugh S, Curtis A, DiMarco J, Ellenbogen K, Epstein A, Ezekowitz M, Fayad D, Gage B, Go A, Hlatky M, Hylek E, Jerosch-Herold M, Konstam M, Lee R, Packer D; Po S, Prystowsky E, Redline S, Rosenberg Y, Van Wagoner D, Wood K, Yue L, Benjamin E. Proceedings of an American Heart Association-- Atrial Fibrillation Summit. Circulation. 2011 Jul 19; 124(3):363-72. Epub 2011 Jun 27.
  28. Yue L, Xie J, Nattel S. Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation. Cardiovasc Res. 2011 Mar 1;89(4):744-53. (Invited review).
  29. Du J, Xie J, Zhang Z, Tsujikawa H, Fusco D, Silverman D, Liang B, Yue L. TRPM7-Mediated Ca2+ Signals Confer Fibrogenesis in Human Atrial Fibrillation. Circ Res. 2010; 106(5):992-1003 (Featured on the cover of March 19 issue, and was the first paper of Editors’ pick).
  30. Zeng H, Guo M, Martins-Taylor K, Wang X, Zhang Z, Park JW, Zhan S, Kronenberg MS, Lichtler A, Liu HX, Chen FP, Yue L, Li XJ, Xu RH. Specification of region-specific neurons including forebrain glutamatergic neurons from human induced pluripotent stem cells. PLoS One. 2010 Jul 29;5(7):e11853.
  31. Chen HC, Xie J, Zhang Z, Su LT, **Yue L, **Runnels LW. Blockade of TRPM7 channel activity and cell death by inhibitors of 5-lipoxygenase. PLoS One. 2010 Jun 17;5(6):e11161. (**co-corresponding author)
  32. Su LT, Chen HC, Gonzalez-Pagan O, Overton JD, Xie J, Yue L, Runnels LW. TRPM7 Activates m-Calpain by Stress-Dependent Stimulation of p38 MAPK and c-Jun N-Terminal Kinase. J Mol Biol. 2010; 5;396(4):858-69. PMID: 20070945.
  33. Du J, Xie J, Yue L. Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity. J. Gen. Physiol. 2009;134(6):471-488.
  34. Heeringa SF, Moller CC, Du J, Yue L, Hinkes B, Chernin G, Vlangos CN, Hoyer PF, Reiser J, Hildebrandt F. A novel TRPC6 mutation that causes childhood FSGS. PLoS One. 2009;4(11):e7771.
  35. Du J, Xie J, Yue L. Intracellular calcium activates TRPM2 and its alternative spliced isoforms. Proc Natl Acad Sci U S A. 2009; 107 (17) 1239-44.
  36. Li M, Du J, Jiang J, Ratzan W, Su L-T, Runnels LW, Yue L. Molecular Determinants of Mg2+ and Ca2+ Permeability and pH Sensitivity in TRPM6 and TRPM7. 10.1074/jbc.M608972200. J. Biol. Chem. 2007; 282(35):25817-25830.
  37. Li M, Jiang J, Yue L. Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7. J Gen Physiol. 2006 May;127(5):525-37.
  38. Su L, Agapito M, Li, Simpson W, Huttenlocher A, Habas R, Yue L, Runnel R. TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain. J Biol Chem. 2006 Apr 21;281(16):11260-70. Epub 2006 Jan 25.
  39. Jiang J, Li M, Yue L. Potentiation of TRPM7 inward currents by acidosis. Journal of General Physiology. 2005; 126 (2) 137-150.
  40. Dessaint J, Yu W, Krause J, Yue L. Yohimbine inhibits firing activities of rat DRG neurons by blocking Na+ and VR1 (TRPV1) channels. European Journal of Pharmacology. 2004; 6;485(1-3):11-20.
  41. Yue L, Navarro B, Ren D, Clapham D.E. The cation selectivity filter of the bacterial sodium channel, NaChBac.Journal of General Physiology. 2002; 120 (6): 845-53
  42. *Runnels L, *Yue L, Clapham D. The TRP-PLIK channel is inactivated by PIP2 hydrolysis. Nature Cell Biology. 2002; 4(5):329-36. (*:co-first author)
  43. Runnels L, Yue L, Clapham D. TRP-PLIK, a bifunctional protein with kinase and ion channel activities(Originally published in Science Express as 10.1126/science.1058519 on January 18, 2001) Science 2001;291 (5506): 1043-1047.
  44. Yue L, Peng J-B, Hediger M A, Clapham D.E. CaT1 Manifests the pore properties of the calcium release activated calcium channel. Nature. 2001; 410, 705 – 709.
  45. *Ren D, *Navarro B, *Xu H, *Yue L, Shi Q, Clapham. A prokaryotic voltage-gated sodium channel. Science. 2001; 294(5550):2372-5. (*: co-first author)
  46. Nattel S, Matthews C, De Blasio E, Han W, Li D, Yue, L. Dose-dependence of 4-aminopyride concentrations and electrophysiological effects in dogs: potential relevance to ionic mechanisms in vivo. Circulation. 2000; 101 (10): 1179-1184.
  47. Nattel S, Yue L, Wang Z. Cardiac ultrarapid delayed rectifiers: A novel potassium current family of functional similarity and molecular diversity (review). Cellular Physiology and Biochemistry 2000; 9: 217-226.
  48. Nattel S, Li D, Yue L. Basic mechanisms of atrial fibrillation-very new insights into very old ideas. Annual Review of Physiology. 2000; 62: 51-77.
  49. Yue L, Feng J, Wang Z, Nattel S. Effects of antiarrhythmic agents on ultra-rapid delayed rectifier potassium channel (IKur.d ) in canine atrium atrial myocytes. Cardiovascular Research. 2000, 46 (1): 151-161.
  50. Yue L, Wang Z, Rindt H, Nattel S. Molecular evidence for a role of Shaw (Kv3) potassium channel subunits in potassium currents of dog atrium. Journal of Physiology. 2000; 527 (3): 467-478.
  51. Gaspo R, Sun H, Fareh S, Yue L, Allen BG, Hebert TE, Nattel S. Biochemical mechanisms of reductions in calcium current caused by atrial tachycardia-induced electrical remodelling. Cardiovascular Research. 1999; 42:434-442.
  52. Yue L, Feng J, Wang Z, Nattel S. Adrenergic modulation of the ultra-rapid delayed K+ current (IKur.d) in canine atrial myocytes. Journal of Physiology. 1999; 516: 385-398.
  53. Yue L, Melnyk P, Gaspo R, Wang Z, Nattel S. The molecular mechanisms underlying ionic remodelling in a dog model of atrial fibrillation. Circulation Research. 1999; 84:776-784.
  54. Li G-R, Feng J, Yue L, Carrier M. Transmural heterogeneity of action potentials and Ito in myocytes isolated from the human right ventricle. American Journal of physiology. 1998;275: H369-H377.
  55. Lu Y, Yue L, Wang Z, Nattel S. Effects of the diuretic agent indapamide on sodium, transient outward and delayed rectifier currents in canine atrial myocytes. Circulation Research. 1998; 83:158-166.
  56. Feng J, Yue L, Wang Z, Nattel S. Ionic mechanisms of action potential heterogeneity in the right atrium.Circulation Research. 1998; 83: 541-551.
  57. Wang Z, Yue L, White M, Pelletier G, Nattel S. Differential expression of inward rectifier potassium channel mRNA transcripts in human atrium versus ventricle. Circulation. 1998; 98: 2422-2428.
  58. Yue L, Feng J, Li G-R, Wang, Z, Nattel S. Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation. Circulation Research 1997; 81:512-525.
  59. Li G-R, Feng J, Yue L, Carrier M, Nattel S. Evidence for two components of delayed rectifier K+ current in human ventricular myocytes. Circulation Research. 1996; 78:689-696.
  60. Yue L, Feng J, Li G-R, Nattel S. A characterization of transient outward and delayed rectifier currents in canine atrial myocytes: Properties of currents and role of cell isolation methods. American Journal of Physiology 1996; 270: H2157-H2168.
  61. Yue L, Feng J, Li G-R, Nattel, S. Characterization of an ultrarapid delayed rectifier potassium channel involved in canine atrial repolarization. Journal of Physiology 1996; 496:647-662.

Book chapters

  1. Yu AS, Yue Z, Feng J, Yue L. Calcium Entry Channels in Non-Excitable Cells . Kozak AJ, Putney JW, editors. United States: CRC Press Tylor & Francis Group; 2017. Chapter 9, Regulation of Orai/STIM Channels by pH ; p.162-176.
  2. Yue L., Xie J., Yue Z. Phospholipid Regulation of Cardiac Ion Channels in Heart Disease. (Chapter 5 in “Cardiovascular Diseases” 2013).