Publications

Fink JJ, Robinson TM, Germain ND, Sirois CL, Bolduc KA, Ward AJ, Rigo F, Chamberlain SJ, Levine ES. Disrupted neuronal maturation in Angelman syndrome-derived induced pluripotent stem cells. Nature Communications. 2017 Apr 24;8:15038.

Yeh ML, Selvam R, Levine ES. BDNF-induced endocannabinoid release modulates neocortical glutamatergic neurotransmission. Synapse. 2017 May;71(5). doi: 10.1002/syn.21962. Epub 2017 Feb 11.

Lieberman R, Kranzler HR, Levine ES, Covault J. Examining FKBP5 mRNA expression in human iPSC-derived neural cells. Psychiatry Research. 2017 Jan;247:172-181.

Zhao L., Yeh M.L., and Levine E.S. Role for Endogenous BDNF in endocannabinoid-mediated long-term depression at neocortical inhibitory synapses. eNeuro . 2015 Feb 28;2(2). 

Germain, N.D., Chen, P., Plocik, A.M., Glatt-Deeley, H., Brown, J., Fink, J.J., Bolduc, K.A., Robinson, T.M., Levine, E.S., Reither, L.T., Graveley, B.R., Lalande, M., Chamberlain, S.J. Gene expression analysis of human induced pluripotent stem cell-derived neurons carrying copy number variants of chromosome 15q11-q13.1. Molecular Autism 2014 Aug 20;5:44.

Zhao L. and Levine E.S. BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling. J Neurophysiology 2014 111(5):1008-15.

Barbarese E, Ifrim MF, Hsieh L, Guo C, Tatavarty V, Maggipinto MJ, Korza G, Tutolo JW, Giampetruzzi A, Le H, Ma XM, Levine E, Bishop B, Kim DO, Kuwada S, Carson JH. Conditional knockout of tumor overexpressed gene in mouse neurons affects RNA granule assembly, granule translation, LTP and short term habituation. PLoS One 2013 8(8):e69989.

Hsieh, L.S., Levine, E.S. Cannabinoid modulation of backpropagating action potential-induced calcium transients in layer 2/3 pyramidal neurons. Cerebral Cortex 2013 23:1731-41.

Lieberman R, Levine ES, Kranzler HR, Abreu C, Covault J Pilot Study of iPS-Derived Neural Cells to Examine Biologic Effects of Alcohol on Human Neurons In Vitro. Alcohol Clin Exp Res. 2012 36(10):1678-87.

Messer RD, Levine ES. Epileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous gamma-aminobutyric acid type B receptor activity. J Neurosci Res. 2012 90(7):1454-1463.

Kiraly DD, Lemtiri-Chlieh F, Levine ES, Mains RE, Eipper BA. Kalirin Binds the NR2B Subunit of the NMDA Receptor, Altering Its Synaptic Localization and Function. J Neurosci 2011 31:12554-12565.

Lemtiri-Chlieh F, Zhao L, Kiraly DD, Eipper BA, Mains RE, Levine ES. Kalirin-7 is necessary for normal NMDA receptor-dependent synaptic plasticity. BMC Neurosci 2011 12:126.

Levine ES. An 'exciting' spin on cannabinoid signalling. J Physiol 2011 589:5347.

Chamberlain SJ, Chen PF, Ng KY, Bourgois-Rocha F, Lemtiri-Chlieh F, Levine ES, Lalande M. Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader-Willi syndromes. Proc Natl Acad Sci USA 2010 107:17668-17673.

Lemtiri-Chlieh F, Levine ES. BDNF evokes release of endogenous cannabinoids at layer 2/3 inhibitory synapses in the neocortex. J Neurophysiol 2010 104:1923-1932.

Ma XM, Kiraly DD, Gaier ED, Wang Y, Kim EJ, Levine ES, Eipper BA, Mains RE. Kalirin-7 is required for synaptic structure and function. J Neurosci 2008 28:12368-12382.

Madara JC, Levine ES. Presynaptic and postsynaptic NMDA receptors mediate distinct effects of brain-derived neurotrophic factor on synaptic transmission. J Neurophysiol 2008 100:3175-3184.

Fortin DA, Levine ES. Differential effects of endocannabinoids on glutamatergic and GABAergic inputs to layer 5 pyramidal neurons. Cereb Cortex 2007 17:163-174.

Lemtiri-Chlieh F, Levine ES. Lack of Depolarization-Induced Suppression of Inhibition (DSI) in Layer 2/3 Interneurons That Receive Cannabinoid-Sensitive Inhibitory Inputs. J Neurophysiol 2007 98:2517-2524.

Kolb JE, Trettel J, Levine ES. BDNF enhancement of postsynaptic NMDA receptors is blocked by ethanol. Synapse 2005 55:52-57.

Fogal B, Trettel J, Uliasz TF, Levine ES, Hewett SJ. Changes in secondary glutamate release underlie the developmental regulation of excitotoxic neuronal cell death. Neuroscience 2005 132(4):929-42.

Fortin DA, Trettel J, Levine ES. Brief trains of action potentials enhance pyramidal neuron excitability via endocannabinoid-mediated suppression of inhibition. J Neurophysiol 2004 92:2105-2112.

Trettel J, Fortin DA, Levine ES. Endocannabinoid signalling selectively targets perisomatic inhibitory inputs to pyramidal neurones in juvenile mouse neocortex. J Physiol 2004 556:95-107.

Trettel J, Levine ES. Endocannabinoids mediate rapid retrograde signaling at interneuron-pyramidal neuron synapses of the neocortex. J Neurophysiol 2003 89:2334-2338.

Trettel J, Levine ES. Cannabinoids depress inhibitory synaptic inputs received by layer 2/3 pyramidal neurons of the neocortex. J Neurophysiol 2002 88:534-539.

Levine ES, Kolb JE (2000). Brain-derived neurotrophic factor increases activity of NR2B-containing N-methyl-D-aspartate receptors in excised patches from hippocampal neurons. J Neurosci Res 62:357-362.

Lin SY, Wu K, Len GW, Xu JL, Levine ES, Suen PC, Mount HT, Black IB. Brain-derived neurotrophic factor enhances association of protein tyrosine phosphatase PTP1D with the NMDA receptor subunit NR2B in the cortical postsynaptic density. Brain Res Mol Brain Res 1999 70:18-25.

Levine ES, Black IB, Plummer MR. Neurotrophin modulation of hippocampal synaptic transmission. Adv Pharmacol 1998 42:921-924.

Levine ES, Crozier RA, Black IB, Plummer MR. Brain-derived neurotrophic factor modulates hippocampal synaptic transmission by increasing N-methyl-D-aspartic acid receptor activity. Proc Natl Acad Sci USA 1998 95:10235-10239.

Lin SY, Wu K, Levine ES, Mount HT, Suen PC, Black IB. BDNF acutely increases tyrosine phosphorylation of the NMDA receptor subunit 2B in cortical and hippocampal postsynaptic densities. Brain Res Mol Brain Res 1998 55:20-27.

Suen PC, Wu K, Xu JL, Lin SY, Levine ES, Black IB. NMDA receptor subunits in the postsynaptic density of rat brain: expression and phosphorylation by endogenous protein kinases. Brain Res Mol Brain Res 1998 59:215-228.

Levine ES, Black IB. Trophic factors, synaptic plasticity, and memory. Ann NY Acad Sci 1997 835:12-19.

Suen PC, Wu K, Levine ES, Mount HT, Xu JL, Lin SY, Black IB. Brain-derived neurotrophic factor rapidly enhances phosphorylation of the postsynaptic N-methyl-D-aspartate receptor subunit 1. Proc Natl Acad Sci USA 1997 94:8191-8195.

Levine ES, Dreyfus CF, Black IB, Plummer MR. Selective role for trkB neurotrophin receptors in rapid modulation of hippocampal synaptic transmission. Brain Res Mol Brain Res 1996 38:300-303.

Wu K, Xu JL, Suen PC, Levine E, Huang YY, Mount HT, Lin SY, Black IB. Functional trkB neurotrophin receptors are intrinsic components of the adult brain postsynaptic density. Brain Res Mol Brain Res 1996 43:286-290.

Levine ES, Dreyfus CF, Black IB, Plummer MR. Differential effects of NGF and BDNF on voltage-gated calcium currents in embryonic basal forebrain neurons. J Neurosci 1995 15:3084-3091.

Levine ES, Dreyfus CF, Black IB, Plummer MR. Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors. Proc Natl Acad Sci USA 1995 92:8074-8077.

Levine ES, Jacobs BL. Microiontophoresis and single-unit recordings of serotonergic neurons in the awake cat. J Chem Neuroanat 1992 5:335-337.

Levine ES, Jacobs BL. Neurochemical afferents controlling the activity of serotonergic neurons in the dorsal raphe nucleus: microiontophoretic studies in the awake cat. J Neurosci 1992 12:4037-4044.

Jacobs BL, Abercrombie ED, Fornal CA, Levine ES, Morilak DA, Stafford IL. Single-unit and physiological analyses of brain norepinephrine function in behaving animals. Prog Brain Res 1991 88:159-165.

Levine ES, Litto WJ, Jacobs BL. Activity of cat locus coeruleus noradrenergic neurons during the defense reaction. Brain Res 1990 531:189-195.

Abercrombie ED, Levine ES, Jacobs BL. Microinjected morphine suppresses the activity of locus coeruleus noradrenergic neurons in freely moving cats. Neurosci Lett 1988 86:334-339.

Northmore DP, Levine ES, Schneider GE. Behavior evoked by electrical stimulation of the hamster superior colliculus. Exp Brain Res 1988 73:595-605.