Publications (and preprints)

  1. Elamin, M, Dumarchey, A, Stoddard, C, Robinson, TM, Cowie, C, Gorka, D, Chamberlain, SJ, Levine, ES. The role of UBE3A in the autism and epilepsy-related Dup15q syndrome using patient-derived, CRISPR-corrected neurons.
  2. Germain, ND, Gorka, D, Drennan, R, Jafar-nejad, P, Whipple, A, Core, L, Levine, ES, Rigo, R, Chamberlain, SJ. Antisense oligonucleotides targeting UBE3A-ATS restore expression of UBE3A by relieving transcriptional interference.
  3. Fink JJ, Schreiner JD, Bloom JE, James J, Baker DS, Robinson TM, Lieberman R, Loew LM, Chamberlain SJ, Levine ES. (2021) Hyperexcitable Phenotypes in Induced Pluripotent Stem Cell-Derived Neurons From Patients With 15q11-q13 Duplication Syndrome, a Genetic Form of Autism. Biol Psychiatry. 90(11):756-765.
  4. Lemtiri-Chlieh F, Baker DS, Al-Naggar IM, Ramasamy R, Kuchel GA, Levine ES, Robson P, Smith PP. (2022) The Hyperpolarization Activated, Cyclic Nucleotide Gated Channel Resides on Myocytes in Mouse Bladders and Contributes to Adrenergic-Induced Detrusor Relaxation. Am J Physiol Regul Integr Comp Physiol.  Epub ahead of print. PMID: 35503519.
  5. Sirois, C. L., Bloom, J. E., Fink, J. J., Gorka, D., Keller, S., Germain, N. D., Levine, E. S., & Chamberlain, S. J. (2020). Abundance and localization of human UBE3A protein isoforms. Human molecular genetics, ddaa1912020 Nov 4;29(18):3021-3031.
  6. Germain, N. D., Levine, E. S., & Chamberlain, S. J. (2020). IPSC Models of Chromosome 15Q Imprinting Disorders: From Disease Modeling to Therapeutic Strategies. Advances in Neurobiology, 25, 55–77.
  7. Lieberman, R., Jensen, K. P., Clinton, K., Levine, E. S., Kranzler, H. R., & Covault, J. (2020). Molecular Correlates of Topiramate and GRIK1 rs2832407 Genotype in Pluripotent Stem Cell-Derived Neural Cultures. Alcoholism, clinical and experimental research, 44(8), 1561–1570.
  8. Selvam R, Yeh ML, Levine ES. (2018) Endogenous cannabinoids mediate the effect of BDNF at CA1 inhibitory synapses in the hippocampus. Synapse e22075. doi: 10.1002/syn.22075. PMID: 30334291.
  9. Fink JJ, Levine ES. (2018) Uncovering True Cellular Phenotypes: Using Induced Pluripotent Stem Cell-Derived Neurons to Study Early Insults in Neurodevelopmental Disorders. Frontiers in Neurology 9:237. doi: 10.3389/fneur.2018.00237. 2018. PMID: 29713304.
  10. Lieberman R, Kranzler HR, Levine ES, Covault J. (2018) Examining the effects of alcohol on GABAA receptor mRNA expression and function in neural cultures generated from control and alcohol dependent donor induced pluripotent stem cells. Alcohol 66:45-53. doi: 10.1016/j.alcohol.2017.08.005. PMID: 29156239.
  11. Yeh ML, Selvam R, Levine ES. (2017) BDNF-induced endocannabinoid release modulates neocortical glutamatergic neurotransmission. Synapse 71(5). doi: 10.1002/syn.21962. PMID: 28164368.
  12. Fink JJ, Robinson TM, Germain ND, Sirois CL, Bolduc KA, Ward AJ, Rigo F, Chamberlain SJ, Levine ES. (2017) Disrupted neuronal maturation in Angelman syndrome-derived induced pluripotent stem cells. Nature Communications 8:15038. doi: 10.1038/ncomms15038. PMID: 28436452.
  13. Yeh ML, Levine ES. (2017) Perspectives on the Role of Endocannabinoids in Autism Spectrum Disorders. OBM Neurobiology 1(2):005. NIHMSID: NIHMS985431.doi: 10.21926/obm.neurobiol.1702005.
  14. Lieberman R, Kranzler HR, Levine ES, Covault J. (2017) Examining FKBP5 mRNA expression in human iPSC-derived neural cells. Psychiatry Research 7:172-181. doi: 10.1016/j.psychres.2016.11.027. PMID: 27915167.
  15. Zhao L, Yeh ML, Levine ES. (2015) Role for Endogenous BDNF in Endocannabinoid-Mediated Long-Term Depression at Neocortical Inhibitory Synapses. eNeuro 2(2). doi: 10.1523/ENEURO.0029-14.2015. PMID: 25938134.
  16. Germain ND, Chen PF, Plocik AM, Glatt-Deeley H, Brown J, Fink JJ, Bolduc KA, Robinson TM, Levine ES, Reiter LT, Graveley BR, Lalande M, Chamberlain SJ. (2014) Gene expression analysis of human induced pluripotent stem cell-derived neurons carrying copy number variants of chromosome 15q11-q13.1. Molecular Autism 5:44. doi: 10.1186/2040-2392-5-44. PMID: 25694803.
  17. Zhao L, Levine ES. BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling. (2014) J Neurophysiology 111(5):1008-15. doi: 10.1152/jn.00554.2013. PMID: 24335212.
  18. Barbarese E, Ifrim MF, Hsieh L, Guo C, Tatavarty V, Maggipinto MJ, Korza G, Tutolo JW, Giampetruzzi A, Le H, Ma XM, Levine E, Bishop B, Kim DO, Kuwada S, Carson JH. (2013) Conditional knockout of tumor overexpressed gene in mouse neurons affects RNA granule assembly, granule translation, LTP and short term habituation. PLoS One 8(8):e69989. doi: 10.1371/journal.pone.0069989. PMID: 23936366.
  19. Hsieh LS, Levine ES. (2013) Cannabinoid modulation of backpropagating action potential-induced calcium transients in layer 2/3 pyramidal neurons. Cerebral Cortex 23(7):1731-41. doi: 10.1093/cercor/bhs168. PMID: 22693342.
  20. Lieberman R, Levine ES, Kranzler HR, Abreu C, Covault J. (2012) Pilot study of iPS-derived neural cells to examine biologic effects of alcohol on human neurons in vitro. Alcohol Clin Exp Res. 36(10):1678-87. doi: 10.1111/j.1530-0277.2012.01792.x. PMID: 22486492.
  21. Messer RD, Levine ES. (2012) Epileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous γ-aminobutyric acid type B receptor activity. J Neuroscience Research 90(7):1454-63. doi: 10.1002/jnr.23027. PMID: 22388975.
  22. Lemtiri-Chlieh F, Zhao L, Kiraly DD, Eipper BA, Mains RE, Levine ES. (2011) Kalirin-7 is necessary for normal NMDA receptor-dependent synaptic plasticity. BMC Neuroscience 12:126. doi: 10.1186/1471-2202-12-126. PMID: 22182308.
  23. Levine ES. An 'exciting' spin on cannabinoid signalling. (2011) Journal of Physiology 589(Pt 22):5347. doi: 10.1113/jphysiol.2011.220541. PMID: 22086251.
  24. Kiraly DD, Lemtiri-Chlieh F, Levine ES, Mains RE, Eipper BA. (2011) Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function. Journal of Neuroscience 31(35):12554-65. doi: 10.1523/JNEUROSCI.3143-11.2011. PMID: 21880917.
  25. Chamberlain SJ, Chen PF, Ng KY, Bourgois-Rocha F, Lemtiri-Chlieh F, Levine ES, Lalande M. (2010) Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader-Willi syndromes. Proc Natl Acad Sci 107(41):17668-73. doi: 10.1073/pnas.1004487107. PMID: 20876107.
  26. Lemtiri-Chlieh F, Levine ES. (2010) BDNF evokes release of endogenous cannabinoids at layer 2/3 inhibitory synapses in the neocortex. Journal of Neurophysiology 104(4):1923-32. doi: 10.1152/jn.00472.2010. PMID: 20719932.
  27. Madara JC, Levine ES. (2008) Presynaptic and postsynaptic NMDA receptors mediate distinct effects of brain-derived neurotrophic factor on synaptic transmission. Journal of Neurophysiology 100(6):3175-84. doi: 10.1152/jn.90880.2008. PMID: 18922945.
  28. Ma XM, Kiraly DD, Gaier ED, Wang Y, Kim EJ, Levine ES, Eipper BA, Mains RE. (2008) Kalirin-7 is required for synaptic structure and function. Journal of Neuroscience 28(47):12368-82. doi: 10.1523/JNEUROSCI.4269-08.2008. PMID: 19020030.
  29. Lemtiri-Chlieh F, Levine ES. (2007) Lack of depolarization-induced suppression of inhibition (DSI) in layer 2/3 interneurons that receive cannabinoid-sensitive inhibitory inputs. Journal of Neurophysiology 98(5):2517-24. doi: 10.1152/jn.00817.2007. PMID: 17881480.
  30. Fortin DA, Levine ES. (2007) Differential effects of endocannabinoids on glutamatergic and GABAergic inputs to layer 5 pyramidal neurons. Cerebral Cortex 17(1):163-74. doi: 10.1093/cercor/bhj133. PMID: 16467564.
  31. Kolb JE, Trettel J, Levine ES. (2005) BDNF enhancement of postsynaptic NMDA receptors is blocked by ethanol. Synapse 55(1):52-7. doi: 10.1002/syn.20090. PMID: 15515007.
  32. Fortin DA, Trettel J, Levine ES. (2004) Brief trains of action potentials enhance pyramidal neuron excitability via endocannabinoid-mediated suppression of inhibition. Journal of Neurophysiology 92(4):2105-12. doi: 10.1152/jn.00351.2004. PMID: 15175370.
  33. Trettel J, Fortin DA, Levine ES. (2004) Endocannabinoid signalling selectively targets perisomatic inhibitory inputs to pyramidal neurones in juvenile mouse neocortex. Journal of Physiology 556(Pt 1):95-107. doi: 10.1113/jphysiol.2003.058198. PMID: 14742727.
  34. Trettel J, Levine ES. (2003) Endocannabinoids mediate rapid retrograde signaling at interneuron right-arrow pyramidal neuron synapses of the neocortex. Journal of Neurophysiology 89(4):2334-8. doi: 10.1152/jn.01037.2002. PMID: 12686587.
  35. Trettel J, Levine ES. (2002) Cannabinoids depress inhibitory synaptic inputs received by layer 2/3 pyramidal neurons of the neocortex. Journal of Neurophysiology 88(1):534-9. doi: 10.1152/jn.2002.88.1.534. PMID: 12091577.
  36. Levine ES, Kolb JE. (2000) Brain-derived neurotrophic factor increases activity of NR2B-containing N-methyl-D-aspartate receptors in excised patches from hippocampal neurons. Journal of Neuroscience Research 62(3):357-62. doi: 10.1002/1097-4547(20001101). PMID: 11054804.
  37. Lin SY, Wu K, Len GW, Xu JL, Levine ES, Suen PC, Mount HT, Black IB. (1999) Brain-derived neurotrophic factor enhances association of protein tyrosine phosphatase PTP1D with the NMDA receptor subunit NR2B in the cortical postsynaptic density. Molecular Brain Research 18;70(1):18-25. PMID: 10381539.
  38. Suen PC, Wu K, Xu JL, Lin SY, Levine ES, Black IB. (1998) NMDA receptor subunits in the postsynaptic density of rat brain: expression and phosphorylation by endogenous protein kinases. Molecular Brain Research 59(2):215-28. PMID: 9729394.
  39. Levine ES, Crozier RA, Black IB, Plummer MR. (1998) Brain-derived neurotrophic factor modulates hippocampal synaptic transmission by increasing N-methyl-D-aspartic acid receptor activity. Proc Natl Acad Sci. 95(17):10235-9. PMID: 9707630.
  40. Lin SY, Wu K, Levine ES, Mount HT, Suen PC, Black IB. (1998) BDNF acutely increases tyrosine phosphorylation of the NMDA receptor subunit 2B in cortical and hippocampal postsynaptic densities. Molecular Brain Research 55(1):20-7. PMID: 9645956.
  41. Levine ES, Black IB, Plummer MR. (1998) Neurotrophin modulation of hippocampal synaptic transmission. Advances in Pharmacology 42:921-4. PMID: 9328048.
  42. Levine ES, Black IB. Trophic factors, synaptic plasticity, and memory. (1997) Ann N Y Acad Sci. 835:12-9. Review. PMID: 9616758.
  43. Suen PC, Wu K, Levine ES, Mount HT, Xu JL, Lin SY, Black IB. (1997) Brain-derived neurotrophic factor rapidly enhances phosphorylation of the postsynaptic N-methyl-D-aspartate receptor subunit 1. Proc Natl Acad Sci 94(15):8191-5. PMID: 9223337.
  44. Levine ES, Dreyfus CF, Black IB, Plummer MR. (1996) Selective role for trkB neurotrophin receptors in rapid modulation of hippocampal synaptic transmission. Molecular Brain Research 38(2):300-3. PMID: 8793119.
  45. Levine ES, Dreyfus CF, Black IB, Plummer MR. Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors. (1995) Proc Natl Acad Sci 92(17):8074-7. PMID: 7644540.
  46. Levine ES, Dreyfus CF, Black IB, Plummer MR. Differential effects of NGF and BDNF on voltage-gated calcium currents in embryonic basal forebrain neurons. (1995) J Neuroscience 15(4):3084-91. PMID: 7722647.
  47. Levine ES, Jacobs BL. (1992) Neurochemical afferents controlling the activity of serotonergic neurons in the dorsal raphe nucleus: microiontophoretic studies in the awake cat. Journal of Neuroscience 12(10):4037-44. PMID: 1357117.
  48. Levine ES, Jacobs BL. Microiontophoresis and single-unit recordings of serotonergic neurons in the awake cat. (1992) Journal of Chemical Neuroanatomy 5(4):335-7. PMID: 1355972.
  49. Jacobs BL, Abercrombie ED, Fornal CA, Levine ES, Morilak DA, Stafford IL. (1991) Single-unit and physiological analyses of brain norepinephrine function in behaving animals. Progress in Brain Research 88:159-65. Review. PMID: 1813921.
  50. Levine ES, Litto WJ, Jacobs BL. (1990) Activity of cat locus coeruleus noradrenergic neurons during the defense reaction. Brain Research 531(1-2):189-95. PMID: 2289120.
  51. Abercrombie ED, Levine ES, Jacobs BL. (1988) Microinjected morphine suppresses the activity of locus coeruleus noradrenergic neurons in freely moving cats. Neuroscience Letters 86(3):334-9. PMID: 3380325.
  52. Northmore DP, Levine ES, Schneider GE. (1988) Behavior evoked by electrical stimulation of the hamster superior colliculus. Experimental Brain Research 73(3):595-605. PMID: 3224669.