Publications (and preprints)

Elamin M, Dumarchey A, Stoddard C, Robinson TM, Cowie C, Gorka D, Chamberlain SJ, Levine ES. The role of UBE3A in the autism and epilepsy-related Dup15q syndrome using patient-derived, CRISPR-corrected neurons. Stem Cell Reports. 2023 Feb 20;. doi: 10.1016/j.stemcr.2023.02.002. [Epub ahead of print] PubMed PMID: 36898382.

Lemtiri-Chlieh F, Levine ES. 2-AG and anandamide enhance hippocampal long-term potentiation via suppression of inhibition. Front Cell Neurosci. 2022;16:1023541. doi: 10.3389/fncel.2022.1023541. eCollection 2022. PubMed PMID: 36212685; PubMed Central PMCID: PMC9534525.

Lemtiri-Chlieh F, Baker DS, Al-Naggar IM, Ramasamy R, Kuchel GA, Levine ES, Robson P, Smith PP. The hyperpolarization-activated, cyclic nucleotide-gated channel resides on myocytes in mouse bladders and contributes to adrenergic-induced detrusor relaxation. Am J Physiol Regul Integr Comp Physiol. 2022 Jul 1;323(1):R110-R122. doi: 10.1152/ajpregu.00277.2021. Epub 2022 May 3. PubMed PMID: 35503519; PubMed Central PMCID: PMC9236879.

Fink JJ, Schreiner JD, Bloom JE, James J, Baker DS, Robinson TM, Lieberman R, Loew LM, Chamberlain SJ, Levine ES. Hyperexcitable Phenotypes in Induced Pluripotent Stem Cell-Derived Neurons From Patients With 15q11-q13 Duplication Syndrome, a Genetic Form of Autism. Biol Psychiatry. 2021 Dec 1;90(11):756-765. doi: 10.1016/j.biopsych.2021.07.018. Epub 2021 Jul 26. PubMed PMID: 34538422; PubMed Central PMCID: PMC8571044.

Ramasamy R, Baker DS, Lemtiri-Chlieh F, Rosenberg DA, Woon E, Al-Naggar IM, Hardy CC, Levine ES, Kuchel GA, Bartley JM, Smith PP. Loss of resilience contributes to detrusor underactivity in advanced age. Biogerontology. 2023 Apr;24(2):163-181. doi: 10.1007/s10522-022-10005-y. Epub 2023 Jan 10. PubMed PMID: 36626035; PubMed Central PMCID: PMC1000633

Sirois CL, Bloom JE, Fink JJ, Gorka D, Keller S, Germain ND, Levine ES, Chamberlain SJ.
Abundance and localization of human UBE3A protein isoforms. Hum Mol Genet. 2020 Nov 4;29(18):3021-3031. doi: 10.1093/hmg/ddaa191. PubMed PMID: 32833011; PubMed Central PMCID: PMC7645711.

Lieberman R, Jensen KP, Clinton K, Levine ES, Kranzler HR, Covault J.
Molecular Correlates of Topiramate and GRIK1 rs2832407 Genotype in Pluripotent Stem Cell-Derived Neural Cultures. Alcohol Clin Exp Res. 2020 Aug;44(8):1561-1570. doi: 10.1111/acer.14399. Epub 2020 Aug 9. PubMed PMID: 32574382; PubMed Central PMCID: PMC7491603.

Germain ND, Levine ES, Chamberlain SJ.
IPSC Models of Chromosome 15Q Imprinting Disorders: From Disease Modeling to Therapeutic Strategies. Adv Neurobiol. 2020;25:55-77. doi: 10.1007/978-3-030-45493-7_3. PubMed PMID: 32578144; PubMed Central PMCID: PMC9305669.

Selvam R, Yeh ML, Levine ES.
Endogenous cannabinoids mediate the effect of BDNF at CA1 inhibitory synapses in the hippocampus. Synapse. 2018 Oct 17;:e22075. doi: 10.1002/syn.22075. [Epub ahead of print] PubMed PMID: 30334291; PubMed Central PMCID: PMC6470051.

Fink JJ, Levine ES.
Uncovering True Cellular Phenotypes: Using Induced Pluripotent Stem Cell-Derived Neurons to Study Early Insults in Neurodevelopmental Disorders. Front Neurol. 2018;9:237. doi: 10.3389/fneur.2018.00237. eCollection 2018. Review. PubMed PMID: 29713304; PubMed Central PMCID: PMC5911479.

Lieberman R, Kranzler HR, Levine ES, Covault J.
Examining the effects of alcohol on GABAA receptor mRNA expression and function in neural cultures generated from control and alcohol dependent donor induced pluripotent stem cells. Alcohol. 2018 Feb;66:45-53. doi: 10.1016/j.alcohol.2017.08.005. Epub 2017 Aug 12. PubMed PMID: 29156239; PubMed Central PMCID: PMC5743620.

Yeh ML, Selvam R, Levine ES.
BDNF-induced endocannabinoid release modulates neocortical glutamatergic neurotransmission. Synapse. 2017 May;71(5). doi: 10.1002/syn.21962. Epub 2017 Feb 11. PubMed PMID: 28164368; PubMed Central PMCID: PMC6086135.

Yeh ML, Levine ES.
Perspectives on the Role of Endocannabinoids in Autism Spectrum Disorders. OBM Neurobiol. 2017;1(2). doi: 10.21926/obm.neurobiol.1702005. Epub 2017 Apr 27. PubMed PMID: 30854511; PubMed Central PMCID: PMC6407886.
Fink JJ, Robinson TM, Germain ND, Sirois CL, Bolduc KA, Ward AJ, Rigo F, Chamberlain SJ, Levine ES. Disrupted neuronal maturation in Angelman syndrome-derived induced pluripotent stem cells. Nat Commun. 2017 Apr 24;8:15038. doi: 10.1038/ncomms15038. PubMed PMID: 28436452; PubMed Central PMCID: PMC5413969.

Lieberman R, Kranzler HR, Levine ES, Covault J.
Examining FKBP5 mRNA expression in human iPSC-derived neural cells. Psychiatry Res. 2017 Jan;247:172-181. doi: 10.1016/j.psychres.2016.11.027. Epub 2016 Nov 24. PubMed PMID: 27915167; PubMed Central PMCID: PMC5191911.

Zhao L, Yeh ML, Levine ES.
Role for Endogenous BDNF in Endocannabinoid-Mediated Long-Term Depression at Neocortical Inhibitory Synapses. eNeuro. 2015 Feb 28;2(2). doi: 10.1523/ENEURO.0029-14.2015. PubMed PMID: 25938134; PubMed Central PMCID: PMC4415885.

Germain ND, Chen PF, Plocik AM, Glatt-Deeley H, Brown J, Fink JJ, Bolduc KA, Robinson TM, Levine ES, Reiter LT, Graveley BR, Lalande M, Chamberlain SJ.
Gene expression analysis of human induced pluripotent stem cell-derived neurons carrying copy number variants of chromosome 15q11-q13.1. Mol Autism. 2014;5:44. doi: 10.1186/2040-2392-5-44. eCollection 2014. PubMed PMID: 25694803; PubMed Central PMCID: PMC4332023.

Zhao L, Levine ES.
BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling. J Neurophysiol. 2014 Mar;111(5):1008-15. doi: 10.1152/jn.00554.2013. Epub 2013 Dec 11. PubMed PMID: 24335212; PubMed Central PMCID: PMC3949235.

Barbarese E, Ifrim MF, Hsieh L, Guo C, Tatavarty V, Maggipinto MJ, Korza G, Tutolo JW, Giampetruzzi A, Le H, Ma XM, Levine E, Bishop B, Kim DO, Kuwada S, Carson JH.
Conditional knockout of tumor overexpressed gene in mouse neurons affects RNA granule assembly, granule translation, LTP and short term habituation. PLoS One. 2013;8(8):e69989. doi: 10.1371/journal.pone.0069989. Print 2013. PubMed PMID: 23936366; PubMed Central PMCID: PMC3735573.

Hsieh LS, Levine ES.
Cannabinoid modulation of backpropagating action potential-induced calcium transients in layer 2/3 pyramidal neurons. Cereb Cortex. 2013 Jul;23(7):1731-41. doi: 10.1093/cercor/bhs168. Epub 2012 Jun 12. PubMed PMID: 22693342; PubMed Central PMCID: PMC3673183.

Lieberman R, Levine ES, Kranzler HR, Abreu C, Covault J.
Pilot study of iPS-derived neural cells to examine biologic effects of alcohol on human neurons in vitro. Alcohol Clin Exp Res. 2012 Oct;36(10):1678-87. doi: 10.1111/j.1530-0277.2012.01792.x. Epub 2012 Apr 6. PubMed PMID: 22486492; PubMed Central PMCID: PMC3424319.

Messer RD, Levine ES.
Epileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous γ-aminobutyric acid type B receptor activity. J Neurosci Res. 2012 Jul;90(7):1454-63. doi: 10.1002/jnr.23027. Epub 2012 Mar 2. PubMed PMID: 22388975; PubMed Central PMCID: PMC3350599.

Lemtiri-Chlieh F, Zhao L, Kiraly DD, Eipper BA, Mains RE, Levine ES.
Kalirin-7 is necessary for normal NMDA receptor-dependent synaptic plasticity. BMC Neurosci. 2011 Dec 19;12:126. doi: 10.1186/1471-2202-12-126. PubMed PMID: 22182308; PubMed Central PMCID: PMC3261125.

Levine ES.
An 'exciting' spin on cannabinoid signalling. J Physiol. 2011 Nov 15;589(Pt 22):5347. doi: 10.1113/jphysiol.2011.220541. PubMed PMID: 22086251; PubMed Central PMCID: PMC3240876.

Kiraly DD, Lemtiri-Chlieh F, Levine ES, Mains RE, Eipper BA.
Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function. J Neurosci. 2011 Aug 31;31(35):12554-65. doi: 10.1523/JNEUROSCI.3143-11.2011. PubMed PMID: 21880917; PubMed Central PMCID: PMC3172699.

Chamberlain SJ, Chen PF, Ng KY, Bourgois-Rocha F, Lemtiri-Chlieh F, Levine ES, Lalande M.
Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader-Willi syndromes. Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17668-73. doi: 10.1073/pnas.1004487107. Epub 2010 Sep 27. PubMed PMID: 20876107; PubMed Central PMCID: PMC2955112.

Lemtiri-Chlieh F, Levine ES.
BDNF evokes release of endogenous cannabinoids at layer 2/3 inhibitory synapses in the neocortex. J Neurophysiol. 2010 Oct;104(4):1923-32. doi: 10.1152/jn.00472.2010. Epub 2010 Aug 18. PubMed PMID: 20719932; PubMed Central PMCID: PMC2957462.

Madara JC, Levine ES.
Presynaptic and postsynaptic NMDA receptors mediate distinct effects of brain-derived neurotrophic factor on synaptic transmission. J Neurophysiol. 2008 Dec;100(6):3175-84. doi: 10.1152/jn.90880.2008. Epub 2008 Oct 15. PubMed PMID: 18922945; PubMed Central PMCID: PMC2604859.

Ma XM, Kiraly DD, Gaier ED, Wang Y, Kim EJ, Levine ES, Eipper BA, Mains RE.
Kalirin-7 is required for synaptic structure and function. J Neurosci. 2008 Nov 19;28(47):12368-82. doi: 10.1523/JNEUROSCI.4269-08.2008. PubMed PMID: 19020030; PubMed Central PMCID: PMC2586970.

Lemtiri-Chlieh F, Levine ES.
Lack of depolarization-induced suppression of inhibition (DSI) in layer 2/3 interneurons that receive cannabinoid-sensitive inhibitory inputs. J Neurophysiol. 2007 Nov;98(5):2517-24. doi: 10.1152/jn.00817.2007. Epub 2007 Sep 19. PubMed PMID: 17881480; NIHMSID:NIHMS234185.

Fortin DA, Levine ES.
Differential effects of endocannabinoids on glutamatergic and GABAergic inputs to layer 5 pyramidal neurons. Cereb Cortex. 2007 Jan;17(1):163-74. doi: 10.1093/cercor/bhj133. Epub 2006 Feb 8. PubMed PMID: 16467564; NIHMSID:NIHMS234183.

Kolb JE, Trettel J, Levine ES.
BDNF enhancement of postsynaptic NMDA receptors is blocked by ethanol. Synapse. 2005 Jan;55(1):52-7. doi: 10.1002/syn.20090. PubMed PMID: 15515007.

Fogal B, Trettel J, Uliasz TF, Levine ES, Hewett SJ.
Changes in secondary glutamate release underlie the developmental regulation of excitotoxic neuronal cell death. Neuroscience. 2005;132(4):929-42. doi: 10.1016/j.neuroscience.2005.01.036. PubMed PMID: 15857699.

Fortin DA, Trettel J, Levine ES.
Brief trains of action potentials enhance pyramidal neuron excitability via endocannabinoid-mediated suppression of inhibition. J Neurophysiol. 2004 Oct;92(4):2105-12. doi: 10.1152/jn.00351.2004. Epub 2004 Jun 2. PubMed PMID: 15175370; NIHMSID:NIHMS234182.

Trettel J, Fortin DA, Levine ES.
Endocannabinoid signalling selectively targets perisomatic inhibitory inputs to pyramidal neurones in juvenile mouse neocortex. J Physiol. 2004 Apr 1;556(Pt 1):95-107. doi: 10.1113/jphysiol.2003.058198. Epub 2004 Jan 23. PubMed PMID: 14742727; PubMed Central PMCID: PMC1664891.

Trettel J, Levine ES.
Endocannabinoids mediate rapid retrograde signaling at interneuron right-arrow pyramidal neuron synapses of the neocortex. J Neurophysiol. 2003 Apr;89(4):2334-8. doi: 10.1152/jn.01037.2002. PubMed PMID: 12686587; NIHMSID:NIHMS234180.

Trettel J, Levine ES.
Cannabinoids depress inhibitory synaptic inputs received by layer 2/3 pyramidal neurons of the neocortex. J Neurophysiol. 2002 Jul;88(1):534-9. doi: 10.1152/jn.2002.88.1.534. PubMed PMID: 12091577; NIHMSID:NIHMS234184.

Levine ES, Kolb JE.
Brain-derived neurotrophic factor increases activity of NR2B-containing N-methyl-D-aspartate receptors in excised patches from hippocampal neurons. J Neurosci Res. 2000 Nov 1;62(3):357-62. doi: 10.1002/1097-4547(20001101)62:3<357::AID-JNR5>3.0.CO;2-6. PubMed PMID: 11054804.

Lin SY, Wu K, Len GW, Xu JL, Levine ES, Suen PC, Mount HT, Black IB.
Brain-derived neurotrophic factor enhances association of protein tyrosine phosphatase PTP1D with the NMDA receptor subunit NR2B in the cortical postsynaptic density. Brain Res Mol Brain Res. 1999 Jun 18;70(1):18-25. doi: 10.1016/s0169-328x(99)00122-9. PubMed PMID: 10381539.

Suen PC, Wu K, Xu JL, Lin SY, Levine ES, Black IB.
NMDA receptor subunits in the postsynaptic density of rat brain: expression and phosphorylation by endogenous protein kinases. Brain Res Mol Brain Res. 1998 Aug 31;59(2):215-28. doi: 10.1016/s0169-328x(98)00157-0. PubMed PMID: 9729394.

Levine ES, Crozier RA, Black IB, Plummer MR.
Brain-derived neurotrophic factor modulates hippocampal synaptic transmission by increasing N-methyl-D-aspartic acid receptor activity. Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10235-9. doi: 10.1073/pnas.95.17.10235. PubMed PMID: 9707630; PubMed Central PMCID: PMC21491.

Lin SY, Wu K, Levine ES, Mount HT, Suen PC, Black IB.
BDNF acutely increases tyrosine phosphorylation of the NMDA receptor subunit 2B in cortical and hippocampal postsynaptic densities. Brain Res Mol Brain Res. 1998 Mar 30;55(1):20-7. doi: 10.1016/s0169-328x(97)00349-5. PubMed PMID: 9645956.

Levine ES, Black IB, Plummer MR.
Neurotrophin modulation of hippocampal synaptic transmission. Adv Pharmacol. 1998;42:921-4. doi: 10.1016/s1054-3589(08)60897-2. PubMed PMID: 9328048.

Levine ES, Black IB.
Trophic factors, synaptic plasticity, and memory. Ann N Y Acad Sci. 1997 Dec 19;835:12-9. doi: 10.1111/j.1749-6632.1997.tb48614.x. Review. PubMed PMID: 9616758.

Suen PC, Wu K, Levine ES, Mount HT, Xu JL, Lin SY, Black IB.
Brain-derived neurotrophic factor rapidly enhances phosphorylation of the postsynaptic N-methyl-D-aspartate receptor subunit 1. Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8191-5. doi: 10.1073/pnas.94.15.8191. PubMed PMID: 9223337; PubMed Central PMCID: PMC21579.

Levine ES, Dreyfus CF, Black IB, Plummer MR.
Selective role for trkB neurotrophin receptors in rapid modulation of hippocampal synaptic transmission. Brain Res Mol Brain Res. 1996 Jun;38(2):300-3. doi: 10.1016/0169-328x(96)00025-3. PubMed PMID: 8793119.

Levine ES, Dreyfus CF, Black IB, Plummer MR.
Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):8074-7. doi: 10.1073/pnas.92.17.8074. PubMed PMID: 7644540; PubMed Central PMCID: PMC41289.

Levine ES, Dreyfus CF, Black IB, Plummer MR.
Differential effects of NGF and BDNF on voltage-gated calcium currents in embryonic basal forebrain neurons. J Neurosci. 1995 Apr;15(4):3084-91. PubMed PMID: 7722647; PubMed Central PMCID: PMC6577759.

Levine ES, Jacobs BL.
Neurochemical afferents controlling the activity of serotonergic neurons in the dorsal raphe nucleus: microiontophoretic studies in the awake cat. J Neurosci. 1992 Oct;12(10):4037-44. PubMed PMID: 1357117; PubMed Central PMCID: PMC6575962.

Levine ES, Jacobs BL.
Microiontophoresis and single-unit recordings of serotonergic neurons in the awake cat. J Chem Neuroanat. 1992 Jul-Aug;5(4):335-7. doi: 10.1016/0891-0618(92)90022-i. PubMed PMID: 1355972.

Jacobs BL, Abercrombie ED, Fornal CA, Levine ES, Morilak DA, Stafford IL.
Single-unit and physiological analyses of brain norepinephrine function in behaving animals. Prog Brain Res. 1991;88:159-65. doi: 10.1016/s0079-6123(08)63805-4. Review. PubMed PMID: 1813921.

Levine ES, Litto WJ, Jacobs BL.
Activity of cat locus coeruleus noradrenergic neurons during the defense reaction. Brain Res. 1990 Oct 29;531(1-2):189-95. doi: 10.1016/0006-8993(90)90773-5. PubMed PMID: 2289120.

Abercrombie ED, Levine ES, Jacobs BL.
Microinjected morphine suppresses the activity of locus coeruleus noradrenergic neurons in freely moving cats. Neurosci Lett. 1988 Apr 12;86(3):334-9. doi: 10.1016/0304-3940(88)90506-x. PubMed PMID: 3380325.

Northmore DP, Levine ES, Schneider GE.
Behavior evoked by electrical stimulation of the hamster superior colliculus. Exp Brain Res. 1988;73(3):595-605. doi: 10.1007/BF00406619. PubMed PMID: 3224669.