Publications | Immuno-Cardio Group

Intracellular immune sensing promotes inflammation via gasdermin D-driven release of a lectin alarmin. Ashley J Russo, Swathy O Vasudevan, Santiago P Méndez-Huergo, Puja Kumari, Antoine Menoret, Shivalee Duduskar, Chengliang Wang, Juan M Pérez Sáez, Margaret M Fettis, Chuan Li, Renjie Liu, Arun Wanchoo, Karthik Chandiran, Jianbin Ruan, Sivapriya Kailasan Vanaja, Michael Bauer, Christoph Sponholz, Gregory A Hudalla, Anthony T Vella, Beiyan Zhou, Sachin D Deshmukh, Gabriel A Rabinovich, Vijay A Rathinam. Nat Immunol. 2021 Feb;22(2):154-165. PMID: 33398185
Identification of splice regulators of fibronectin-EIIIA and EIIIB by direct measurement of exon usage in a flow-cytometry based CRISPR screen.
Hensel JA, Heineman BD, Kimble AL, Jellison ER, Reese B, Murphy PA. Sci Rep. 2021 Oct 6;11(1):19835. doi: 10.1038/s41598-021-99079-1. PMID: 34615942
Evolution, Chance, and Aging. Frankel S, Rogina B. Front Genet. 2021 Sep 9;12:733184. doi: 10.3389/fgene.2021.733184. eCollection 2021. PMID: 34567
Lymphocyte Activation Gene-3 Regulates Dendritic Cell Metabolic Programing and T Cell Priming Function. Garcia Cruz D, Giri RR, Gamiotea Turro D, Balsbaugh JL, Adler AJ, Rodriguez A. J Immunol. 2021 Nov 1;207(9):2374-2384. doi: 10.4049/jimmunol.2001188. Epub 2021 Sep 29. PMID: 34588222
Short Communication: Plasma Lymphocyte Activation Gene 3 and Subclinical Coronary Artery Disease in the Multicenter AIDS Cohort Study. Sarkar S, Haberlen S, Post WS, Kelesidis T, Wiley D, Kingsley L, Kim EY, Palella FJ, Witt MD, Budoff MJ, Rodriguez A, Brown TT. AIDS Res Hum Retroviruses. 2021 Sep 20. doi: 10.1089/aid.2021.0035. Online ahead of print. PMID: 34542321
Mitofusin-2 regulates leukocyte adhesion and β2 integrin activation. Liu W, Hsu AY, Wang Y, Lin T, Sun H, Pachter JS, Groisman A, Imperioli M, Yungher FW, Hu L, Wang P, Deng Q, Fan Z. J Leukoc Biol. 2021 Sep 8. doi: 10.1002/JLB.1A0720-471R. Online ahead of print. PMID: 34494308
An Essential Role of UBXN3B in B Lymphopoiesis. Geng T, Yang D, Lin T, Harrison AG, Wang B, Torrance B, Wang K, Wang Y, Yang L, Haynes L, Cheng G, Vella AT, Fikrig E, Wang P. bioRxiv. 2021 Aug 24:2021.03.04.433919. doi: 10.1101/2021.03.04.433919. Preprint. PMID: 34462748
Visualization of integrin molecules by fluorescence imaging and techniques. Cai C, Sun H, Hu L, Fan Z. Biocell. 2021;45(2):229-257. doi: 10.32604/biocell.2021.014338. Epub 2021 Feb 19. PMID: 34219865
β2 integrin activation and signal transduction in leukocyte recruitment. Sun H, Hu L, Fan Z. Am J Physiol Cell Physiol. 2021 Aug 1;321(2):C308-C316. doi: 10.1152/ajpcell.00560.2020. Epub 2021 Jun 16. PMID: 34133240
Editorial: Imaging and Mechanism of Leukocyte Recruitment and Function in Inflammation and Infections. Sun H, Huo Y, Fan Z. Front Cell Dev Biol. 2021 May 7;9:690003. doi: 10.3389/fcell.2021.690003. eCollection 2021.PMID: 34026766
UBX Domain Protein 6 Positively Regulates JAK-STAT1/2 Signaling. Ketkar H, Harrison AG, Graziano VR, Geng T, Yang L, Vella AT, Wang P. J Immunol. 2021 Jun 1;206(11):2682-2691. doi: 10.4049/jimmunol.1901337. Epub 2021 May 21. PMID: 34021047
The Activation and Regulation of β2 Integrins in Phagocytes and Phagocytosis. Sun H, Zhi K, Hu L, Fan Z. Front Immunol. 2021 Mar 31;12:633639. doi: 10.3389/fimmu.2021.633639. eCollection 2021. PMID: 33868253
Granulocyte-macrophage colony-stimulating factor initiates amniotic membrane rupture and preterm birth in a mouse model. Nold C, Esteves K, Jensen T, Vella AT. Am J Reprod Immunol. 2021 Aug;86(2):e13424. doi: 10.1111/aji.13424. Epub 2021 Apr 6. PMID: 33772943
Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis. Marki A, Buscher K, Lorenzini C, Meyer M, Saigusa R, Fan Z, Yeh YT, Hartmann N, Dan JM, Kiosses WB, Golden GJ, Ganesan R, Winkels H, Orecchioni M, McArdle S, Mikulski Z, Altman Y, Bui J, Kronenberg M, Chien S, Esko JD, Nizet V, Smalley D, Roth J, Ley K.
A Critical Role for STING Signaling in Limiting Pathogenesis of Chikungunya Virus. Geng T, Lin T, Yang D, Harrison AG, Vella AT, Fikrig E, Wang P. J Infect Dis. 2021 Jun 15;223(12):2186-2196. doi: 10.1093/infdis/jiaa694. PMID: 33161431
Kindlin-3 recruitment to the plasma membrane precedes high-affinity β2-integrin and neutrophil arrest from rolling. Wen L, Marki A, Roy P, McArdle S, Sun H, Fan Z, Gingras AR, Ginsberg MH, Ley K. Blood. 2021 Jan 7;137(1):29-38. doi: 10.1182/blood.2019003446. PMID: 32777822
A mouse model of the regression of alcoholic hepatitis: Monitoring the regression of hepatic steatosis, inflammation, oxidative stress, and NAD⁺ metabolism upon alcohol withdrawal. Kang H, Kim MB, Park YK, Lee JY. J Nutr Biochem. 2021 Sep 12;99:108852. doi: 10.1016/j.jnutbio.2021.108852. Online ahead of print. PMID: 34525389
The loss of histone deacetylase 4 in macrophages exacerbates hepatic and adipose tissue inflammation in male but not in female mice with diet-induced non-alcoholic steatohepatitis. Kang H, Lee Y, Kim MB, Hu S, Jang H, Park YK, Lee JY. J Pathol. 2021 Nov;255(3):319-329. doi: 10.1002/path.5758. Epub 2021 Aug 10. PMID: 34374436
Nicotinamide riboside, an NAD⁺ precursor, attenuates inflammation and oxidative stress by activating sirtuin 1 in alcohol-stimulated macrophages. Kang H, Park YK, Lee JY. Lab Invest. 2021 Sep;101(9):1225-1237. doi: 10.1038/s41374-021-00599-1. Epub 2021 Apr 12. PMID: 33846538
Inhibition of alcohol-induced inflammation and oxidative stress by astaxanthin is mediated by its opposite actions in the regulation of sirtuin 1 and histone deacetylase 4 in macrophages. Kang H, Park YK, Lee JY. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Jan;1866(1):158838. doi: 10.1016/j.bbalip.2020.158838. Epub 2020 Oct 13. PMID: 33065288
Senolytics alleviate the degenerative disorders of temporomandibular joint in old age. Zhou Y, Al-Naggar IMA, Chen PJ, Gasek NS, Wang K, Mehta S, Kuchel GA, Yadav S, Xu M. Aging Cell. 2021 Jul;20(7):e13394. doi: 10.1111/acel.13394. Epub 2021 Jun 8. PMID: 34101970
Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice. Zhou Y, Xin X, Wang L, Wang B, Chen L, Liu O, Rowe DW, Xu M. NPJ Regen Med. 2021 Jun 11;6(1):34. doi: 10.1038/s41536-021-00145-z. PMID: 34117259

Super-STORM: Molecular Modeling to Achieve Single-molecule Localization with STORM Microscopy. Fan Z, Mikulski Z, McArdle S, Sundd P, Ley K. STARprotocol. 2020; 1(1): 100012.
A flexible kink in the transmembrane domain impairs β2 integrin extension and cell arrest from rolling. Sun H*, Fan Z*, Gingras AR, Lopez-Ramirez MA, Ginsberg MH, Ley K. Journal of Leukocyte Biology. 2020; 107(2): 175-183. (*co-first authors)
Visualization of integrin molecules by fluorescence imaging and techniques. Cai C, Sun H, Hu L, Fan Z. Biocell. 2020, in press.
Distinct integrin activation pathways for effector and regulatory T cell trafficking and function. Sun H, Lagarrigue F, Wang H, Fan Z, Lopez-Ramirez MA, Chang JT, Ginsberg MH. Journal of Experimental Medicine. 2021; 218 (2): e20201524.
Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis. Marki A, Buscher K, Lorenzini C, Meyer M, Saigusa R, Fan Z, Yeh YT, Hartmann N, Dan JM, Kiosses WB, Golden GJ, Ganesan R, Winkels H, Orecchioni M, McArdle S, Mikulski Z, Altman Y, Bui J, Kronenberg M, Chien S, Esko JD, Nizet V, Smalley D, Roth J, Ley K. Journal of Experimental Medicine. 2021 Mar 1;218(3):e20200551.
Kindlin-3 recruitment to the plasma membrane precedes high affinity β2 integrin and neutrophil arrest from rolling. Wen L, Marki A, Roy P, McArdle S, Sun H, Fan Z, Gingras A, Ginsberg M, Ley K. Blood. 2020, blood.2019003446. doi: 10.1182/blood.2019003446. Online ahead of print.
SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19. Zhang S, Liu Y, Wang X, Yang L, Li H, Wang Y, Liu M, Zhao X, Xie Y, Yang Y, Zhang S, Fan Z, Dong J, Yuan Z, Ding Z, Zhang Y, Hu L. Journal of Hematology & Oncology. 2020; 13: 120.
Imaging of the immune system - towards a subcellular and molecular understanding. Wen L, Fan Z, Mikulski Z, Ley, K. Journal of Cell Science. 2020; 133, jcs234922.
Decreased miR-150 in obesity-associated type 2 diabetic mice increases intraocular inflammation and exacerbates retinal dysfunction. Yu F, Chapman S, Pham DL, Ko ML, Zhou B, Ko GY.BMJ Open Diabetes Res Care. 2020 Sep;8(1):e001446. doi: 10.1136/bmjdrc-2020-001446.
STAT3 signaling in myeloid cells promotes pathogenic myelin-specific T cell differentiation and autoimmune demyelination. Lu HC, Kim S, Steelman AJ, Tracy K, Zhou B, Michaud D, Hillhouse AE, Konganti K, Li J.Proc Natl Acad Sci U S A. 2020 Mar 10;117(10):5430-5441. doi: 10.1073/pnas.1913997117. Epub 2020 Feb 24.
Alternative Splicing of FN (Fibronectin) Regulates the Composition of the Arterial Wall Under Low Flow.
Murphy PA, Jailkhani N, Nicholas SA, Del Rosario AM, Balsbaugh JL, Begum S, Kimble A, Hynes RO. Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):e18-e32. doi: 10.1161/ATVBAHA.120.314013. Epub 2020 Nov 19. PMID: 33207933

IL-17 inhibits CXCL9/10-mediated recruitment of CD8₊ cytotoxic T cells and regulatory T cells to colorectal tumors. Chen J, Ye X, Pitmon E, Lu M, Wan J, Jellison ER, Adler AJ, Vella AT, Wang K. J Immunother Cancer. 2019 Nov 27;7(1):324. doi: 10.1186/s40425-019-0757-z. PMID: 31775909.
Costimulation Induces CD4 T Cell Antitumor Immunity via an Innate-like Mechanism. Morales Del Valle C, Maxwell JR, Xu MM, Menoret A, Mittal P, Tsurutani N, Adler AJ, Vella AT*. Cell Rep. 2019 Apr 30;27(5):1434-1445.e3. doi: 10.1016/j.celrep.2019.04.016. PMID: 31042471.
Long Noncoding RNAs in Host-Pathogen Interactions. Agliano F, Rathinam VA, Medvedev AE, Vanaja SK, Vella AT*. Trends Immunol. 2019 Jun;40(6):492-510. doi: 10.1016/j.it.2019.04.001. Epub 2019 Apr 30. Review. PMID: 31053495.
Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis. Willis CM, Nicaise AM, Menoret A, Ryu JK, Mendiola AS, Jellison ER, Givogri MI, Han DK, Bongarzone ER, Akassoglou K, Vella AT, Crocker SJ. Proc Natl Acad Sci USA. 2019 May 21;116(21):10488-10493. doi: 10.1073/pnas.1816911116. Epub 2019 May 8. PMID: 31068461.
A mathematical model of combined CD8 T cell costimulation by 4-1BB (CD137) and OX40 (CD134) receptors. Konstorum A, Vella AT, Adler AJ, Laubenbacher RC. Sci Rep. 2019 Jul 26;9(1):10862. doi: 10.1038/s41598-019-47333-y. PMID: 31350431.
Functional polymeric nerve guidance conduits and drug delivery strategies for peripheral nerve repair and regeneration. Manoukian OS, Baker JT, Rudraiah S, Arul MR, Vella AT, Domb AJ, Kumbar SG. J Control Release. 2019 Nov 19;317:78-95. doi: 10.1016/j.jconrel.2019.11.021. [Epub ahead of print] Review. PMID: 31756394.
MicroRNA Regulated Macrophage Activation in Obesity. Li C, Qu L, Farragher C, Vella A, Zhou B*. J Transl Int Med. 2019 Jul 11;7(2):46-52. doi: 10.2478/jtim-2019-0011. eCollection 2019 Jun. PMID: 31380236.
Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis. Xiong X, Kuang H, Ansari S, Liu T, Gong J, Wang S, Zhao XY, Ji Y, Li C, Guo L, Zhou L, Chen Z, Leon-Mimila P, Chung MT, Kurabayashi K, Opp J, Campos-Pérez F, Villamil-Ramírez H, Canizales-Quinteros S, Lyons R, Lumeng CN, Zhou B, Qi L, Huertas-Vazquez A, Lusis AJ, Xu XZS, Li S, Yu Y, Li JZ, Lin JD. Mol Cell. 2019 Aug 8;75(3):644-660.e5. doi: 10.1016/j.molcel.2019.07.028. PMID: 31398325.
Single-cell transcriptomics–based MacSpectrum reveals macrophage activation signatures in diseases Li C, Menoret A, Farragher C, Ouyang Z, Bonin C, Holvoet P, Vella AT, Zhou B*. JCI Insight. 2019 Apr 16. PubMed PMID: 30990466.
Direct CD137 costimulation of CD8 T cells promotes retention and innate-like function within nascent atherogenic foci. Xu MM, Ménoret A, Nicholas SE, Gunther S, Sundberg EJ, Zhou B, Rodriguez A, Murphy PA*, Vella AT*. Am J Physiol Heart Circ Physiol. 2019 April. Pubmed PMID 30978132.
Activated T effector seeds: Cultivating atherosclerotic plaque through alternative activation. Xu MM, Murphy PA, Vella AT*. Am J Physiol Heart Circ Physiol. 2019 Mar 29. doi: 10.1152/ajpheart.00148.2019. [Epub ahead of print] PubMed PMID: 30925075.
Glutamine Metabolism in Macrophages: A Novel Target for Obesity/Type 2 Diabetes. Ren W, Xia Y, Chen S, Wu G, Bazer FW, Zhou B, Tan B, Zhu G, Deng J, Yin Y. Adv Nutr. 2019 Mar 1;10(2):321-330. doi: 10.1093/advances/nmy084. PMID: 30753258.
Frontline Science: A flexible kink in the transmembrane domain impairs β2 integrin extension and cell arrest from rolling. Sun H, Fan Z, Gingras AR, Lopez-Ramirez MA, Ginsberg MH, Ley K. J Leukoc Biol. 2019 Sep 1. doi: 10.1002/JLB.1HI0219-073RR. [Epub ahead of print] PMID: 31475386.
Super-STORM: using molecular structure modeling to sharp images of single molecule localization microscopy. Fan Z, Mikulski Z, McArdle S, Sundd P, Ley K. STAR Protocols. 2019; in press. w. PMID: 29154757.
Generation of Hematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells. Oguro H. Methods Mol Biol. 2019;2048:245-257. doi: 10.1007/978-1-4939-9728-2_19. PMID: 31396942
The Roles of Cholesterol and Its Metabolites in Normal and Malignant Hematopoiesis. Oguro H. Front Endocrinol (Lausanne). 2019 Apr 2;10:204. doi: 10.3389/fendo.2019.00204. eCollection 2019. PMID: 31001203

Soluble CD83 Alleviates Experimental Autoimmune Uveitis by Inhibiting Filamentous Actin-Dependent Calcium Release in Dendritic Cells. Lin W, Buscher K, Wang B, Fan Z, Song N, Li P, Yue Y, Li B, Li C, Bi H. Front Immunol. 2018 Jul 9;9:1567. doi: 10.3389/fimmu.2018.01567. eCollection 2018. PMID: 30050530
Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development. Sun H, Lagarrigue F, Gingras AR, Fan Z, Ley K, Ginsberg MH. J Cell Biol. 2018 Apr 2;217(4):1453-1465. doi: 10.1083/jcb.201707055. Epub 2018 Mar 13. PMID: 29535192.
A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense. Wolf D, Anto-Michel N, Blankenbach H, Wiedemann A, Buscher K, Hohmann JD, Lim B, Bäuml M, Marki A, Mauler M, Duerschmied D, Fan Z, Winkels H, Sidler D, Diehl P, Zajonc DM, Hilgendorf I, Stachon P, Marchini T, Willecke F, Schell M, Sommer B, von Zur Muhlen C, Reinöhl J, Gerhardt T, Plow EF, Yakubenko V, Libby P, Bode C, Ley K, Peter K, Zirlik A. Nat Commun. 2018 Feb 6;9(1):525. doi: 10.1038/s41467-018-02896-8. PMID: 29410422.
ICAM-1 depletion in the center of immunological synapses is important for calcium releasing in T-cells. Suo Y, Lin W, Deng Y, Fan Z, Qin L, Jiang G, Chu Y, Wei X. Journal of Innovative Optical Health Sciences, 2018; 11(2): 1750015.
Leukocyte Adhesion: Fundamental Mechanisms. Ley K, Fan Z. Handbook of Inflammation. 2018.
Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis. Banerjee I, Behl B, Mendonca M, Shrivastava G, Russo AJ, Menoret A, Ghosh A, Vella AT, Vanaja SK, Sarkar SN, Fitzgerald KA, Rathinam VAK. Immunity. 2018 Sep 18;49(3):413-426.e5. doi: 10.1016/j.immuni.2018.07.006. Epub 2018 Aug 28. PMID: 30170814.
High-Affinity Bent β2-Integrin Molecules in Arresting Neutrophils Face Each Other through Binding to ICAMs In cis. Fan Z, Kiosses WB, Sun H, Orecchioni M, Ghosheh Y, Zajonc DM, Arnaout MA, Gutierrez E, Groisman A, Ginsberg MH, Ley K. Cell Rep. 2019 Jan 2; 26(1):119-130.e5. doi: 10.1016/j.celrep.2018.12.038. PMID: 30605669.
T cell-directed IL-17 production by lung granular γδ T cells is coordinated by a novel IL-2 and IL-1β circuit. Ménoret A, Buturla JA, Xu MM, Svedova J, Kumar S, Rathinam VAK, Vella AT*. Mucosal Immunol. 2018 Sep;11(5):1398-1407. doi: 10.1038/s41385-018-0037-0. Epub 2018 Jun 15. PMID: 29907868.
An Immunotherapeutic CD137 Agonist Releases Eomesodermin from ThPOK Repression in CD4 T Cells. Mittal P, Abblett R, Ryan JM, Hagymasi AT, Agyekum-Yamoah A, Svedova J, Reiner SL, St Rose MC, Hanley MP, Vella AT, Adler AJ. J Immunol. 2018 Feb 15;200(4):1513-1526. doi: 10.4049/jimmunol.1701039. Epub 2018 Jan 5. PMID: 29305435.
A novel biologic platform elicits profound T cell costimulatory activity and antitumor immunity in mice. Ryan JM, Mittal P, Menoret A, Svedova J, Wasser JS, Adler AJ, Vella AT*. Cancer Immunol Immunother. 2018 Apr;67(4):605-613. doi: 10.1007/s00262-018-2116-1. Epub 2018 Jan 11.PMID: 29327109.
Understanding how combinatorial targeting of TLRs and TNFR family costimulatory members promote enhanced T cell responses. Shinde P, Bharat V, Rodriguez-Oquendo A, Zhou B, Vella AT*. Expert Opin Biol Ther. 2018 Oct;18(10):1073-1083. doi: 10.1080/14712598.2018.1518422. Epub 2018 Sep 12. Review. PMID: 30169979.
Functional antagonism of sphingosine-1-phosphate receptor 1 prevents cuprizone-induced demyelination. Kim S, Bielawski J, Yang H, Kong Y, Zhou B, Li J. Glia. 2018 Mar;66(3):654-669. doi: 10.1002/glia.23272. Epub 2017 Nov 29. PMID: 29193293.
Endothelial FN (Fibronectin) Deposition by α5β1 Integrins Drives Atherogenic Inflammation. Al-Yafeai Z, Yurdagul A Jr, Peretik JM, Alfaidi M, Murphy PA, Orr AW. Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2601-2614. doi: 10.1161/ATVBAHA.118.311705. PubMed PMID: 30354234.
Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow. Murphy PA, Butty VL, Boutz PL, Begum S, Kimble AL, Sharp PA, Burge CB, Hynes RO. Elife. 2018 Jan 2;7. pii: e29494. doi: 10.7554/eLife.29494.
Macrophage polarization and meta-inflammation. Li C, Xu MM, Wang K, Adler AJ, Vella AT*, Zhou B*. Transl Res. 2018 Jan;191:29-44. doi: 10.1016/j.trsl.2017.10.004. Epub 2017 Nov 3. Review. PMID: 29154757.

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