{"id":8,"date":"2019-04-25T14:43:44","date_gmt":"2019-04-25T18:43:44","guid":{"rendered":"https:\/\/health.uconn.edu\/yan-lab\/?page_id=8"},"modified":"2024-02-15T13:10:25","modified_gmt":"2024-02-15T18:10:25","slug":"publications","status":"publish","type":"page","link":"https:\/\/health.uconn.edu\/yan-lab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Publications<\/h1>\n<\/div><\/div><\/div><\/div>

Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance<\/a>
\nSingh, N., Das, B., Zhou, J., Hu, X., & Yan, R. (2022). Science advances, 8(29), eabo3610.<\/span><\/p>\n<\/div><\/div>

BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1<\/a>
\nSingh, N., Benoit, M. R., Zhou, J., Das, B., Davila-Velderrain, J., Kellis, M., Tsai, L. H., Hu, X., & Yan, R. (2022).\u00a0<\/span>Science advances<\/i>,\u00a0<\/span>8<\/i>(24), eabo1286.<\/p>\n

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Metabotropic Glutamate Receptors in Alzheimer's Disease Synaptic Dysfunction: Therapeutic Opportunities and Hope for the Future<\/a>
\nSrivastava, A., Das, B., Yao, A. Y., & Yan, R. (2020).\u00a0<\/span>Journal of Alzheimer's disease : JAD<\/i>,\u00a0<\/span>78<\/i>(4), 1345\u20131361.<\/span><\/p>\n<\/div><\/div>

Activated CX3CL1\/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction<\/a>
\nFan, Q., He, W., Gayen, M., Benoit, M. R., Luo, X., Hu, X., & Yan, R. (2020).\u00a0<\/span>The Journal of neuroscience : the official journal of the Society for Neuroscience<\/i>,\u00a0<\/span>40<\/i>(5), 1133\u20131144.<\/p>\n<\/div><\/div>

The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer's amyloid pathology<\/a>
\nFan, Q., Gayen, M., Singh, N., Gao, F., He, W., Hu, X., Tsai, L. H., & Yan, R. (2019).\u00a0<\/span>The Journal of experimental medicine<\/i>,\u00a0<\/span>216<\/i>(8), 1891\u20131903.<\/p>\n<\/div><\/div>

CX3CL1 intracellular domain and adult neurogenesis<\/a>
\nBenoit, M. R., Gayen, M., & Yan, R. (2019). CX3CL1 intracellular domain and adult neurogenesis. Aging, 11(23), 10783\u201310785.<\/span><\/p>\n<\/div><\/div>

A Close Look at BACE1 Inhibitors for Alzheimer's Disease Treatment<\/a>
\nDas, B., & Yan, R. (2019).\u00a0<\/span>CNS drugs<\/i>,\u00a0<\/span>33<\/i>(3), 251\u2013263.<\/p>\n<\/div><\/div>

Sequential formation of different layers of dystrophic neurites in Alzheimer's brains.<\/a>
\nSharoar, M. G., Hu, X., Ma, X. M., Zhu, X., & Yan, R. (2019).\u00a0<\/span>Molecular psychiatry<\/i>,\u00a0<\/span>24<\/i>(9), 1369\u20131382.<\/p>\n<\/div><\/div>

Full List of Articles<\/a><\/p>\n

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Publications Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance Singh, N., Das, B., Zhou, J., Hu, X., & Yan, R. (2022). Science advances, 8(29), eabo3610. BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1 Singh, N., Benoit, M. R., Zhou, J., Das, B., Davila-Velderrain, J., Kellis, M., Tsai, L. H., […]<\/p>\n","protected":false},"author":38,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-blank.php","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-22 14:17:53","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/yan-lab\/wp-json\/wp\/v2\/pages\/8"}],"collection":[{"href":"https:\/\/health.uconn.edu\/yan-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/health.uconn.edu\/yan-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/yan-lab\/wp-json\/wp\/v2\/users\/38"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/yan-lab\/wp-json\/wp\/v2\/comments?post=8"}],"version-history":[{"count":10,"href":"https:\/\/health.uconn.edu\/yan-lab\/wp-json\/wp\/v2\/pages\/8\/revisions"}],"predecessor-version":[{"id":193,"href":"https:\/\/health.uconn.edu\/yan-lab\/wp-json\/wp\/v2\/pages\/8\/revisions\/193"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/yan-lab\/wp-json\/wp\/v2\/media?parent=8"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}