{"id":18,"date":"2019-09-10T15:40:01","date_gmt":"2019-09-10T19:40:01","guid":{"rendered":"https:\/\/health.uconn.edu\/bae-lab\/?page_id=18"},"modified":"2025-07-18T11:08:07","modified_gmt":"2025-07-18T15:08:07","slug":"publications","status":"publish","type":"page","link":"https:\/\/health.uconn.edu\/xiong-lab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Selected Publications as the corresponding author (*)<\/h3>

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Liu,\u00a0<\/sup>Q., Huang, B., Guiberson, N., Chen, S., Zhu, D., Ma, G., Ma, X., Crittenden, J.R., Yu, J., Graybiel, A, M., Dawson, T.M.*, Dawson, V.L.*, Xiong, Y.*<\/strong>. (2024) CalDAG-GEFI acts as a Guanine Nucleotide Exchange Factor for LRRK2 to regulate LRRK2 function and neurodegeneration.<\/a> Science Advances <\/em><\/strong>Nov 22;10(47):eadn5417. <\/span>doi: 10.1126\/sciadv.adn5417. <\/span>(*corresponding author)<\/p>\n

Xiong, Y.<\/b>*, <\/b>Yu, J. (2024) LRRK2 in Parkinson's disease: Upstream regulation and Therapeutic targeting.<\/a> Trends Mol. Med. <\/em><\/strong>Oct;30(10):982-996.\u00a0doi: 10.1016\/j.molmed.2024.07.003.\u00a0Epub 2024 Aug 16 (Invited review, *corresponding author)<\/span><\/p>\n

Liu, Q., Zhu, D., Li, N., Chen, S., Hu, L., Yu, J., Xiong, Y.*<\/strong>. (2023) Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE-mediated mRNA decay in Parkinson's disease.<\/a> The EMBO Journal <\/em><\/strong>42(15): e113410 doi:\u00a010.15252\/embj.2022113410 (*corresponding author)
\n\u00a0 \u00a0 \u00a0Comment in \"Targeting LRRK2 mRNA stability in Parkinson's disease<\/a>\" (Fasiczka & Hilfiker, Trends Neurosci. <\/u>2023).
\n\u00a0 \u00a0 \u00a0Media reports: Fox News<\/a>; MedicalXpress<\/a>; OAN news<\/a>;\u00a0 UConn Today<\/a><\/em><\/em><\/p>\n

Hu, L., Brichalli, W., Li, N., Chen, S., Cheng, Y., Liu, Q., Xiong, Y.*,<\/strong>\u00a0Yu, J.*. (2022) Myotubularin functions through actomyosin to interact with the Hippo pathway.<\/a>\u00a0EMBO Reports <\/strong><\/em>23(12):e55851 doi: 10.15252\/embr.202255851 (*corresponding author)<\/p>\n

Liu, Q., Bautista-Gomez, J., Higgins, D.A., Yu, J. *,\u00a0Xiong, Y.* <\/strong>(2021) Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration<\/a>. Science Signaling<\/strong><\/em> 14(693):eabg3555. (*corresponding author) Media reports: UConn Today<\/a>.<\/p>\n

Xiong, Y.<\/b>*, <\/b>Yu, J.* (2020) Linking the leucine-rich repeat kinase 2 (LRRK2) gene, animal models and Parkinson\u2019s disease.<\/a> The<\/b> Neuroscience of Parkinson\u2019s disease: Volume 2:<\/b><\/em>Genetics, Neurology, Behavior, and Diet in Parkinson's Disease (Elsevier, ISBN: 9780128159507). (Book chapter, *corresponding author)<\/p>\n

Li, N., Liu, Q., Xiong, Y*<\/b>, Yu, J.*. (2019) Headcase and Unkempt regulate tissue growth and cell cycle progression in response to nutrient restriction.<\/a> Cell Reports<\/b><\/em>\u00a026,733-747 (*corresponding author)<\/p>\n

Xiong, Y.*,<\/b> Neifert, S., Karuppagounder, S. S., Liu, Q., Stankowski, J. N., Lee, B. D., Ko, H. S., Lee, Y., Grima, J. C., Mao, X., Jiang, H., Kang, S. U., Swing, D., Iacovitti, L., Tessarollo, L., Dawson, T. M.*, and Dawson, V.L.* (2018). Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice.<\/a> Proc Natl Acad Sci U S A<\/em> <\/b>115(7):1635-1640. (*corresponding author)<\/p>\n

Xiong, Y.<\/b>*, <\/b>Yu, J.* (2018) Modeling Parkinson\u2019s disease in Drosophila: What have we learned for dominant traits?<\/a> Front Neurol. <\/b><\/em>Apr 9;9:228. (*corresponding author)<\/p>\n

Xiong, Y.*,<\/b> Dawson, TM., Dawson, VL.* (2017) Models of LRRK2 associated Parkinson\u2019s disease.<\/a> Adv. Neurobiol<\/b>.<\/em> (Book Chapter) pii: ENEURO.0004-17.2017 (*corresponding author)<\/p>\n

Xiong, Y.*,<\/b> Neifert, S., Karuppagounder, SS., Stankowski, JN., Lee, BD., Grima, JC., Chen, G., Ko, HS., Lee, Y., Swing, D., Tessarollo, L., Dawson, TM., Dawson, VL*<\/b>. (2017) Overexpression of Parkinson\u2019s disease-associated mutation LRRK2 G2019S in mouse forebrain induces behavioral deficits and -synuclein pathology.<\/a> eNeuro<\/b><\/em> 10.1523\/ENEURO.0004-17.2017 (*corresponding author)<\/p>\n

 <\/p>\n

Complete List of Publications: MyNCBI<\/a><\/strong><\/p>\n

 <\/p>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

Liu,\u00a0Q., Huang, B., Guiberson, N., Chen, S., Zhu, D., Ma, G., Ma, X., Crittenden, J.R., Yu, J., Graybiel, A, M., Dawson, T.M.*, Dawson, V.L.*, Xiong, Y.*. (2024) CalDAG-GEFI acts as a Guanine Nucleotide Exchange Factor for LRRK2 to regulate LRRK2 function and neurodegeneration. Science Advances Nov 22;10(47):eadn5417. doi: 10.1126\/sciadv.adn5417. (*corresponding author) Xiong, Y.*, Yu, J. […]<\/p>\n","protected":false},"author":38,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-09 12:44:08","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/xiong-lab\/wp-json\/wp\/v2\/pages\/18"}],"collection":[{"href":"https:\/\/health.uconn.edu\/xiong-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/health.uconn.edu\/xiong-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/xiong-lab\/wp-json\/wp\/v2\/users\/38"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/xiong-lab\/wp-json\/wp\/v2\/comments?post=18"}],"version-history":[{"count":89,"href":"https:\/\/health.uconn.edu\/xiong-lab\/wp-json\/wp\/v2\/pages\/18\/revisions"}],"predecessor-version":[{"id":638,"href":"https:\/\/health.uconn.edu\/xiong-lab\/wp-json\/wp\/v2\/pages\/18\/revisions\/638"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/xiong-lab\/wp-json\/wp\/v2\/media?parent=18"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}