Liu, Q., Huang, B., Guiberson, N., Chen, S., Zhu, D., Ma, G., Ma, X., Crittenden, J.R., Yu, J., Graybiel, A, M., Dawson, T.M.*, Dawson, V.L.*, Xiong, Y.*. (2024) CalDAG-GEFI acts as a Guanine Nucleotide Exchange Factor for LRRK2 to regulate LRRK2 function and neurodegeneration. Science Advances (Accepted, *corresponding author)

Xiong, Y.*, Yu, J. (2024) LRRK2 in Parkinson's disease: Upstream regulation and Therapeutic targeting. Trends Mol. Med. Oct;30(10):982-996. doi: 10.1016/j.molmed.2024.07.003. Epub 2024 Aug 16 (Invited review, *corresponding author)

Liu, Q., Zhu, D., Li, N., Chen, S., Hu, L., Yu, J., Xiong, Y.*. (2023) Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE-mediated mRNA decay in Parkinson's disease. The EMBO Journal 42(15): e113410 doi: 10.15252/embj.2022113410 (*corresponding author)
     Comment in "Targeting LRRK2 mRNA stability in Parkinson's disease" (Fasiczka & Hilfiker, Trends Neurosci. 2023).
     Media reports: Fox News; MedicalXpress; OAN news;  UConn Today

Hu, L., Brichalli, W., Li, N., Chen, S., Cheng, Y., Liu, Q., Xiong, Y.*, Yu, J.*. (2022) Myotubularin functions through actomyosin to interact with the Hippo pathway. EMBO Reports 23(12):e55851 doi: 10.15252/embr.202255851 (*corresponding author)

Liu, Q., Bautista-Gomez, J., Higgins, D.A., Yu, J. *, Xiong, Y.* (2021) Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration. Science Signaling 14(693):eabg3555. (*corresponding author) Media reports: UConn Today.

Xiong, Y.*, Yu, J.* (2020) Linking the leucine-rich repeat kinase 2 (LRRK2) gene, animal models and Parkinson’s disease. The Neuroscience of Parkinson’s disease: Volume 2:Genetics, Neurology, Behavior, and Diet in Parkinson's Disease (Elsevier, ISBN: 9780128159507). (Book chapter, *corresponding author)

Li, N., Liu, Q., Xiong, Y*, Yu, J.*. (2019) Headcase and Unkempt regulate tissue growth and cell cycle progression in response to nutrient restriction. Cell Reports 26,733-747 (*corresponding author)

Xiong, Y.*, Neifert, S., Karuppagounder, S. S., Liu, Q., Stankowski, J. N., Lee, B. D., Ko, H. S., Lee, Y., Grima, J. C., Mao, X., Jiang, H., Kang, S. U., Swing, D., Iacovitti, L., Tessarollo, L., Dawson, T. M.*, and Dawson, V.L.* (2018). Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice. Proc Natl Acad Sci U S A 115(7):1635-1640. (*corresponding author)

Xiong, Y.*, Yu, J.* (2018) Modeling Parkinson’s disease in Drosophila: What have we learned for dominant traits? Front Neurol. Apr 9;9:228. (*corresponding author)

Xiong, Y.*, Dawson, TM., Dawson, VL.* (2017) Models of LRRK2 associated Parkinson’s disease. Adv. Neurobiol. (Book Chapter) pii: ENEURO.0004-17.2017 (*corresponding author)

Xiong, Y.*, Neifert, S., Karuppagounder, SS., Stankowski, JN., Lee, BD., Grima, JC., Chen, G., Ko, HS., Lee, Y., Swing, D., Tessarollo, L., Dawson, TM., Dawson, VL*. (2017) Overexpression of Parkinson’s disease-associated mutation LRRK2 G2019S in mouse forebrain induces behavioral deficits and -synuclein pathology. eNeuro 10.1523/ENEURO.0004-17.2017 (*corresponding author)

 

Other Publications

Ma SX, Seo BA, Kim D, Xiong Y, Kwon SH, Brahmachari S, Kim S, Kam TI, Nirujogi RS, Kwon SH, Dawson VL, Dawson TM, Pandey A, Na CH, Ko HS. (2021) Complement and Coagulation Cascades are Potentially Involved in Dopaminergic Neurodegeneration in α-Synuclein-Based Mouse Models of Parkinson's Disease. J Proteome Res. 20(7):3428-3443.

Fais M, Sanna G, Galioto M, Nguyen TTD, Trần MUT, Sini P, Carta F, Turrini F, Xiong Y, Dawson TM, Dawson VL, Crosio C, Iaccarino C. (2021) LRRK2 Modulates the Exocyst Complex Assembly by Interacting with Sec8. Cells 10(2):203.

Pirooznia SK, Yuan C, Khan MR, Karuppagounder SS, Wang L, Xiong Y, Kang SU, Lee Y, Dawson VL, Dawson TM. (2020) PARIS Induced Defects in Mitochondrial Biogenesis Drive Dopamine Neuron Loss Under Conditions of Parkin or PINK1 Deficiency. Mol. Neurodegener. 15(1):17

Jia, K., Huang, G., Wu, W., Shrestha, R.,We, B., Xiong, Y., Li, P. (2019) In vivo Methylation of OLA1 Revealed by Activity-Based Target Profiling of NTMT1. Chemical Science 10, 8094-8099

Mao X, Ou MT, Karuppagounder SS, Kam TI, Yin X, Xiong Y, Ge P, Umanah GE, Brahmachari S, Shin JH, Kang HC, Zhang J, Xu J, Chen R, Park H, Andrabi SA, Kang SU, Gonçalves RA, Liang Y, Zhang S, Qi C, Lam S, Keiler JA, Tyson J, Kim D, Panicker N, Yun SP, Workman CJ, Vignali DA, Dawson VL, Ko HS, Dawson TM. (2016) Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3. Science Sep 30;353(6307). pii: aah3374.

Karuppagounder SS, Xiong Y, Lee Y, Lawless MC, Kim D, Nordquist E, Martin I, Ge P, Brahmachari S, Jhaldiyal A, Kumar M, Andrabi SA, Dawson TM, Dawson VL. (2016) LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity. J Chem Neuroanat. S0891-0618(15)30038-7.

Martin, I., Kim, J., Lee, B., Kang, H., Xu, J., Jia, H., Stankowski JN., Kim, M., Zhong, J., Kumar, M., Andrabi, S., Xiong, Y., Dickson, D., Wszolek, Z., Pandey, A., Dawson, TM, Dawson, VL. (2014) Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson’s disease. Cell 157(2):472-85.

Stafa, K.,, Tsika, E.,, Moser, R., Musso, A., Glauser, L., Jones, A., Biskup, S., Xiong, Y., Bandopadhyay, R., Dawson, V., Dawson, T., Moore, D. (2014) Functional Interaction of Parkinson’s Disease-Associated LRRK2 with Members of the Dynamin GTPase Superfamily. Hum. Mol. Genet. 23 (8): 2055-77.

Migheli, R., Giudice, M., Spissu, Y., Sanna, G., Xiong, Y., Dawson, TM., Dawson, VL., Galioto, M., Rochitta, G., Biosa, A., Serra, P., Carri, M., Crosio, C., Iaccarino, C. (2013) LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization. PLoS One 8(10): e77198

Xiong, Y., Dawson, VL, Dawson, TM. (2012) LRRK2 GTPase dysfunction in the pathogenesis of Parkinson’s disease. Biochem. Soc. Trans. 40 (5): 1074-1079

Xiong, Y., Yuan, C., Chen, R., Dawson, TM. Dawson, VL. (2012) ArfGAP1 is a GTPase   activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2. J. Neurosci. 32(11): 3877-3886.

Nikonova, EV.^#, Xiong, Y.^#, Tanis, KQ., Moore, DJ., Dawson, VL., Vogel, RL., Finney, EM., Stone, DJ., Reynolds, IJ., Kern, JT., Dawson, TM. (2012) Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological progress modulated by LRRK2 activity. Hum. Mol. Genet. 21(1): 163-74. (^#Contributed equally)

Zhang, J., Wang, Y., Chi, Z., Keuss, M., Pai, YM., Kang, HC., Shin, J., Byugyenko, A., Wang, H., Xiong, Y., Pletnikov, M., Mattson, M., Dawson, TM., Dawson, VL. (2011) The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior. Cell 145(2): 284-99.

Li, X., Moore, D.J., Xiong, Y., Dawson, T.M. and Dawson, V.L. (2010) Reevaluation of phosphorylationsites in the Parkinson disease-associated leucine-rich repeat kinase 2. J Biol Chem. 285(38): 29569-29576.

Xiong Y, Coombes CE, Kilaru A, Li X, Gitler AD, Bowers JW, Dawson VL, Dawson TM, Moore DJ. (2010) GTPase Activity Plays a Key Role in the Pathobiology of LRRK2. PLoS Genet. 6(4): e1000902.

 

Complete List of Publications: PubMed