Liu, Q., Huang, B., Guiberson, N., Chen, S., Zhu, D., Ma, G., Ma, X., Crittenden, J.R., Yu, J., Graybiel, A, M., Dawson, T.M.*, Dawson, V.L.*, Xiong, Y.*. (2024) CalDAG-GEFI acts as a Guanine Nucleotide Exchange Factor for LRRK2 to regulate LRRK2 function and neurodegeneration. Science Advances Nov 22;10(47):eadn5417. doi: 10.1126/sciadv.adn5417. (*corresponding author)

Xiong, Y.*, Yu, J. (2024) LRRK2 in Parkinson's disease: Upstream regulation and Therapeutic targeting. Trends Mol. Med. Oct;30(10):982-996. doi: 10.1016/j.molmed.2024.07.003. Epub 2024 Aug 16 (Invited review, *corresponding author)

Liu, Q., Zhu, D., Li, N., Chen, S., Hu, L., Yu, J., Xiong, Y.*. (2023) Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE-mediated mRNA decay in Parkinson's disease. The EMBO Journal 42(15): e113410 doi: 10.15252/embj.2022113410 (*corresponding author)
     Comment in "Targeting LRRK2 mRNA stability in Parkinson's disease" (Fasiczka & Hilfiker, Trends Neurosci. 2023).
     Media reports: Fox News; MedicalXpress; OAN news;  UConn Today

Hu, L., Brichalli, W., Li, N., Chen, S., Cheng, Y., Liu, Q., Xiong, Y.*, Yu, J.*. (2022) Myotubularin functions through actomyosin to interact with the Hippo pathway. EMBO Reports 23(12):e55851 doi: 10.15252/embr.202255851 (*corresponding author)

Liu, Q., Bautista-Gomez, J., Higgins, D.A., Yu, J. *, Xiong, Y.* (2021) Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration. Science Signaling 14(693):eabg3555. (*corresponding author) Media reports: UConn Today.

Xiong, Y.*, Yu, J.* (2020) Linking the leucine-rich repeat kinase 2 (LRRK2) gene, animal models and Parkinson’s disease. The Neuroscience of Parkinson’s disease: Volume 2:Genetics, Neurology, Behavior, and Diet in Parkinson's Disease (Elsevier, ISBN: 9780128159507). (Book chapter, *corresponding author)

Li, N., Liu, Q., Xiong, Y*, Yu, J.*. (2019) Headcase and Unkempt regulate tissue growth and cell cycle progression in response to nutrient restriction. Cell Reports 26,733-747 (*corresponding author)

Xiong, Y.*, Neifert, S., Karuppagounder, S. S., Liu, Q., Stankowski, J. N., Lee, B. D., Ko, H. S., Lee, Y., Grima, J. C., Mao, X., Jiang, H., Kang, S. U., Swing, D., Iacovitti, L., Tessarollo, L., Dawson, T. M.*, and Dawson, V.L.* (2018). Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice. Proc Natl Acad Sci U S A 115(7):1635-1640. (*corresponding author)

Xiong, Y.*, Yu, J.* (2018) Modeling Parkinson’s disease in Drosophila: What have we learned for dominant traits? Front Neurol. Apr 9;9:228. (*corresponding author)

Xiong, Y.*, Dawson, TM., Dawson, VL.* (2017) Models of LRRK2 associated Parkinson’s disease. Adv. Neurobiol. (Book Chapter) pii: ENEURO.0004-17.2017 (*corresponding author)

Xiong, Y.*, Neifert, S., Karuppagounder, SS., Stankowski, JN., Lee, BD., Grima, JC., Chen, G., Ko, HS., Lee, Y., Swing, D., Tessarollo, L., Dawson, TM., Dawson, VL*. (2017) Overexpression of Parkinson’s disease-associated mutation LRRK2 G2019S in mouse forebrain induces behavioral deficits and -synuclein pathology. eNeuro 10.1523/ENEURO.0004-17.2017 (*corresponding author)

 

Complete List of Publications: MyNCBI