{"id":550,"date":"2018-03-29T15:57:10","date_gmt":"2018-03-29T19:57:10","guid":{"rendered":"https:\/\/health.uconn.edu\/vascular-biology\/?page_id=550"},"modified":"2018-05-17T11:59:09","modified_gmt":"2018-05-17T15:59:09","slug":"caromile-lab","status":"publish","type":"page","link":"https:\/\/health.uconn.edu\/vascular-biology\/caromile-lab\/","title":{"rendered":"Caromile Lab"},"content":{"rendered":"<div id=\"pl-550\"  class=\"panel-layout\" ><div id=\"pg-550-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-550-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-550-0-0-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"0\" ><div class=\"textwidget\"><h3><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-454 lazyload\" data-src=\"https:\/\/health.uconn.edu\/vascular-biology\/wp-content\/uploads\/sites\/118\/2015\/03\/PSMA.jpg\" alt=\"\" width=\"2749\" height=\"1024\" data-srcset=\"https:\/\/health.uconn.edu\/vascular-biology\/wp-content\/uploads\/sites\/118\/2015\/03\/PSMA.jpg 2749w, https:\/\/health.uconn.edu\/vascular-biology\/wp-content\/uploads\/sites\/118\/2015\/03\/PSMA-300x112.jpg 300w, https:\/\/health.uconn.edu\/vascular-biology\/wp-content\/uploads\/sites\/118\/2015\/03\/PSMA-768x286.jpg 768w, https:\/\/health.uconn.edu\/vascular-biology\/wp-content\/uploads\/sites\/118\/2015\/03\/PSMA-1024x381.jpg 1024w\" data-sizes=\"(max-width: 2749px) 100vw, 2749px\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 2749px; --smush-placeholder-aspect-ratio: 2749\/1024;\" \/><noscript><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-454\" src=\"https:\/\/health.uconn.edu\/vascular-biology\/wp-content\/uploads\/sites\/118\/2015\/03\/PSMA.jpg\" alt=\"\" width=\"2749\" height=\"1024\" srcset=\"https:\/\/health.uconn.edu\/vascular-biology\/wp-content\/uploads\/sites\/118\/2015\/03\/PSMA.jpg 2749w, https:\/\/health.uconn.edu\/vascular-biology\/wp-content\/uploads\/sites\/118\/2015\/03\/PSMA-300x112.jpg 300w, https:\/\/health.uconn.edu\/vascular-biology\/wp-content\/uploads\/sites\/118\/2015\/03\/PSMA-768x286.jpg 768w, https:\/\/health.uconn.edu\/vascular-biology\/wp-content\/uploads\/sites\/118\/2015\/03\/PSMA-1024x381.jpg 1024w\" sizes=\"(max-width: 2749px) 100vw, 2749px\" \/><\/noscript><\/h3>\n<h3><strong>Overview<\/strong><\/h3>\n<p>My laboratory utilizes approaches from tumor biology, biochemistry, mathematical modeling and metabolomics to discover new and effective ways of detecting and treating prostate cancer. We are particularly interested in the transmembrane peptidase biomarker prostate specific membrane antigen (PSMA) and its role in detection and management of prostate cancer as well as its molecular role in disease progression. PSMA is a folate hydrolase encoded by the FOLH1 gene that is expressed at low levels on the cell surface of normal prostate epithelium and other organs, and is progressively and specifically upregulated in approximately 80% of primary PC tumors where it correlates negatively with prognosis. Current research projects involve: 1) defining PSMAs role in signal transduction pathway switching in prostate cancer; 2) exploring the functional contributions of prostate cancer-associated SNPs in the gene encoding PSMA, FOLH1, in African American men from NCI GMaP region 4; 3) mathematical modeling of PSMA and in glutamate addiction and prostate cancer progression. These studies may lead not only lead to the development of novel therapeutic strategies in the treatment of and detection of prostate cancer by preventing the progression, metastasis, and vascularization of tumors but since cancer is one of the most common diseases worldwide, this research is an important tool for researchers, clinicians, policy makers, and citizens in understanding this disease.<\/p>\n<h3><strong>New Publication<\/strong><\/h3>\n<p><a href=\"http:\/\/stke.sciencemag.org\/cgi\/content\/full\/sigtrans;10\/470\/eaag3326?ijkey=Kvh5zDLuZIJog&amp;keytype=ref&amp;siteid=sigtrans\">PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer.<\/a> Caromile LA, Dortche K, Rahman MM, Grant CL, Stoddard C, Ferrer FA, Shapiro LH. Sci Signal. 2017 Mar 14;10(470). pii: eaag3326. doi: 10.1126\/scisignal.aag3326.<\/p>\n<h3><strong>Publications<\/strong><\/h3>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=leslie+caromile\" target=\"_blank\" rel=\"noopener noreferrer\">All Caromile Lab Publications<\/a><\/p>\n<h3><strong>In the News<\/strong><\/h3>\n<p>&nbsp;<\/p>\n<p><a href=\"http:\/\/today.uconn.edu\/2017\/03\/mark-malignancy-identified-prostate-cancer\/\">Mark of Malignancy Identified in Prostate Cancer<\/a><\/p>\n<p>The prostates that have PSMA (left) clearly have more tumor cells (purple) that have expanded the ducts to occlude the normally clear areas, perturbed the cellular organization within the ducts and disrupted the overall structure of the prostate; consistent with rapidly progressing tumors. Cells in the tumors without PSMA (right) appear to be growing more slowly since the ductal and interstitial space and structure is maintained somewhat, consistent with a less aggressive tumor.<\/p>\n<p><a href=\"https:\/\/mydigitalpublication.com\/publication\/?i=496005#{%22issue_id%22:496005,%22page%22:32}\">\u201cUncharted Territory: Native American Leaders in the STEM Fields\u201d. Diversity in Action Magazine. May\/June 2018. Pg. 30.<\/a><\/p>\n<p>The remarkable contributions of Native Americans in STEM.<\/p>\n<p class=\"page_title\"><a href=\"https:\/\/www.keystonesymposia.org\/index.cfm?e=Web.Diversity.NativeAmericanMonth\" class=\"broken_link\">Keystone Symposia Celebrates National American Indian &amp; Alaska Native Heritage Month (November 1-30, 2016)<\/a><\/p>\n<p>At Keystone Symposia, the Diversity in Life Science Programs (DLSP) would like to share some of the thoughts of our Fellows who are of American Indian\/Alaskan Native descent regarding how they perceive their role and responsibilities as scientists of color. In 1976, the United States' bicentennial year, Congress passed a resolution authorizing President Ford to proclaim a week in October as \"Native American Awareness Week.\" On October 8, 1976, he issued his presidential proclamation doing so. Since then, Congress and the President have\u00a0observed\u00a0a day, a week or a month in honor of the American Indian and Alaska Native people.<\/p>\n<p class=\"entry-title\"><a href=\"https:\/\/today.uconn.edu\/school-stories\/diversity-matters-drug-trials\/\">Why Diversity Matters in Drug Trials\u00a0<\/a><\/p>\n<div class=\"share-contain\">\n<div class=\"sharrre-container sharrre-container-active sharrre\">A recent conference at Case Western Reserve University in Cleveland discussed the challenges and scientific advantages of diversity in the study and implementation of precision medicine. Leslie Caromile, assistant professor in Center for Vascular Biology, was among the attendees. Here she elaborates on the importance of diversity in this area and what she brings back from this scientific conference. Caromile, who is of Eastern Cherokee heritage, is a\u00a0<a href=\"http:\/\/updates.uchc.edu\/?p=2230\">Keystone Symposia Fellow<\/a>. The Keystone Symposia Fellowship Program is for life science researchers from historically underrepresented populations who in turn mentor aspiring scientists from underrepresented populations.<\/div>\n<\/div>\n<div><\/div>\n<div><\/div>\n<p>&nbsp;<\/p>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Overview My laboratory utilizes approaches from tumor biology, biochemistry, mathematical modeling and metabolomics to discover new and effective ways of detecting and treating prostate cancer. We are particularly interested in the transmembrane peptidase biomarker prostate specific membrane antigen (PSMA) and its role in detection and management of prostate cancer as well as its molecular role [&hellip;]<\/p>\n","protected":false},"author":403,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-22 16:31:18","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/vascular-biology\/wp-json\/wp\/v2\/pages\/550"}],"collection":[{"href":"https:\/\/health.uconn.edu\/vascular-biology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/health.uconn.edu\/vascular-biology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/vascular-biology\/wp-json\/wp\/v2\/users\/403"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/vascular-biology\/wp-json\/wp\/v2\/comments?post=550"}],"version-history":[{"count":13,"href":"https:\/\/health.uconn.edu\/vascular-biology\/wp-json\/wp\/v2\/pages\/550\/revisions"}],"predecessor-version":[{"id":602,"href":"https:\/\/health.uconn.edu\/vascular-biology\/wp-json\/wp\/v2\/pages\/550\/revisions\/602"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/vascular-biology\/wp-json\/wp\/v2\/media?parent=550"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}