{"id":797,"date":"2017-03-27T12:55:02","date_gmt":"2017-03-27T16:55:02","guid":{"rendered":"https:\/\/health.uconn.edu\/synapse\/?page_id=797"},"modified":"2024-08-13T10:39:22","modified_gmt":"2024-08-13T14:39:22","slug":"metaslider-image-1-2","status":"publish","type":"page","link":"https:\/\/health.uconn.edu\/synapse\/metaslider-image-1-2\/","title":{"rendered":"Novel HA epitope-tagged knock in mouse"},"content":{"rendered":"<div id=\"pl-797\"  class=\"panel-layout\" ><div id=\"pg-797-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-797-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-797-0-0-0\" class=\"so-panel widget widget_widget_sp_image widget_sp_image panel-first-child panel-last-child\" data-index=\"0\" ><h3 class=\"widget-title\"> <\/h3><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"708\" alt=\" \" class=\"attachment-full\" style=\"max-width: 100%;\" srcset=\"https:\/\/health.uconn.edu\/synapse\/wp-content\/uploads\/sites\/110\/2024\/08\/1200Figure-3-HA-mouse.jpg 1200w, https:\/\/health.uconn.edu\/synapse\/wp-content\/uploads\/sites\/110\/2024\/08\/1200Figure-3-HA-mouse-300x177.jpg 300w, https:\/\/health.uconn.edu\/synapse\/wp-content\/uploads\/sites\/110\/2024\/08\/1200Figure-3-HA-mouse-1024x604.jpg 1024w, https:\/\/health.uconn.edu\/synapse\/wp-content\/uploads\/sites\/110\/2024\/08\/1200Figure-3-HA-mouse-768x453.jpg 768w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" src=\"https:\/\/health.uconn.edu\/synapse\/wp-content\/uploads\/sites\/110\/2024\/08\/1200Figure-3-HA-mouse.jpg\" \/><\/div><\/div><div id=\"pgc-797-0-1\"  class=\"panel-grid-cell\" ><div id=\"panel-797-0-1-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"1\" ><div class=\"textwidget\"><p><span data-contrast=\"auto\" xml:lang=\"EN-US\" lang=\"EN-US\" class=\"TextRun SCXW115189542 BCX8\"><span class=\"NormalTextRun SCXW115189542 BCX8\">We have created novel<\/span><span class=\"NormalTextRun SCXW115189542 BCX8\"> HA<\/span><span class=\"NormalTextRun SCXW115189542 BCX8\"> epitope-tagged knock in mouse lines to <\/span><span class=\"NormalTextRun SCXW115189542 BCX8\">facilitate<\/span><span class=\"NormalTextRun SCXW115189542 BCX8\"> biochemistry, map expression locations, and determination of subcellular localization. We have discovered that C1QL1, previously assumed to be a synaptic protein expressed by neurons, is expressed in a glia sub-type called oligodendrocyte progenitor cells (OPCs; marked by the protein PDGFR\u03b1).\u00a0<\/span><\/span><span class=\"EOP SCXW115189542 BCX8\" data-ccp-props=\"{&quot;134233279&quot;:true,&quot;134245417&quot;:false,&quot;201341983&quot;:0,&quot;335559739&quot;:200,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>We have created novel HA epitope-tagged knock in mouse lines to facilitate biochemistry, map expression locations, and determination of subcellular localization. We have discovered that C1QL1, previously assumed to be a synaptic protein expressed by neurons, is expressed in a glia sub-type called oligodendrocyte progenitor cells (OPCs; marked by the protein PDGFR\u03b1).\u00a0\u00a0<\/p>\n","protected":false},"author":97,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-06-06 18:37:48","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/synapse\/wp-json\/wp\/v2\/pages\/797"}],"collection":[{"href":"https:\/\/health.uconn.edu\/synapse\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/health.uconn.edu\/synapse\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/synapse\/wp-json\/wp\/v2\/users\/97"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/synapse\/wp-json\/wp\/v2\/comments?post=797"}],"version-history":[{"count":2,"href":"https:\/\/health.uconn.edu\/synapse\/wp-json\/wp\/v2\/pages\/797\/revisions"}],"predecessor-version":[{"id":803,"href":"https:\/\/health.uconn.edu\/synapse\/wp-json\/wp\/v2\/pages\/797\/revisions\/803"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/synapse\/wp-json\/wp\/v2\/media?parent=797"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}