{"id":238,"date":"2017-10-31T13:44:43","date_gmt":"2017-10-31T17:44:43","guid":{"rendered":"https:\/\/health.uconn.edu\/structural-biology\/?page_id=238"},"modified":"2017-11-03T15:41:07","modified_gmt":"2017-11-03T19:41:07","slug":"janus-faced-atracotoxin-a-blocker-of-insect-potassium-channels","status":"publish","type":"page","link":"https:\/\/health.uconn.edu\/structural-biology\/protein-structures\/janus-faced-atracotoxin-a-blocker-of-insect-potassium-channels\/","title":{"rendered":"Janus-Faced Atracotoxin, a Blocker of Insect Potassium Channels"},"content":{"rendered":"<div id=\"pl-238\"  class=\"panel-layout\" ><div id=\"pg-238-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-238-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-238-0-0-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"0\" ><div class=\"textwidget\"><p><div style=\"width: 400px;\" class=\"wp-video\"><!--[if lt IE 9]><script>document.createElement('video');<\/script><![endif]-->\n<video class=\"wp-video-shortcode\" id=\"video-238-1\" width=\"400\" height=\"360\" loop=\"1\" autoplay=\"1\" preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"https:\/\/health.uconn.edu\/structural-biology\/wp-content\/uploads\/sites\/177\/2017\/11\/Janus-Faced-Atracotoxin-1.mp4?_=1\" \/><a href=\"https:\/\/health.uconn.edu\/structural-biology\/wp-content\/uploads\/sites\/177\/2017\/11\/Janus-Faced-Atracotoxin-1.mp4\">https:\/\/health.uconn.edu\/structural-biology\/wp-content\/uploads\/sites\/177\/2017\/11\/Janus-Faced-Atracotoxin-1.mp4<\/a><\/video><\/div><\/p>\n<\/div><\/div><\/div><div id=\"pgc-238-0-1\"  class=\"panel-grid-cell\" ><div class=\"panel-cell-style panel-cell-style-for-238-0-1\" ><div id=\"panel-238-0-1-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"1\" ><div class=\"textwidget\"><p>The Janus-faced atracotoxins are a family of insect-specific excitatory neurotoxins isolated from the venom of Australian funnel-web spiders. In addition to a strikingly asymmetric distribution of charged residues, from which their name is derived, they contain an extremely rare vicinal disulfide bond which is essential for neurotoxic activity. The toxins are selective for insect voltage-gated potassium channels. Alanine-scanning mutagenesis revealed that the bioactive surface comprises a bipartite surface patch, shown in yellow and red, on one face of the toxin.<\/p>\n<hr \/>\n<p>Wang, X-H., Connor, M., Smith, R., Maciejewski, M.W., Howden, M.E.H., Nicholson, G. M., Christie, M. J. and King, G. F. (2000) Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bond.\u00a0<em>Nature Structural Biology<\/em>\u00a07, 505-513.<\/p>\n<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=10881200&amp;dopt=Abstract\">PubMed<\/a>\u00a0|\u00a0<a href=\"http:\/\/www.nature.com\/cgi-taf\/DynaPage.taf?file=\/nsb\/journal\/v7\/n6\/abs\/nsb0600_505.html&amp;dynoptions=doi1035925748\" class=\"broken_link\">Journal<\/a>\u00a0|\u00a0<a href=\"http:\/\/www.rcsb.org\/pdb\/cgi\/explore.cgi?pid=266241037829953&amp;pdbId=1DL0\" class=\"broken_link\">PDB Link<\/a><\/p>\n<p><a href=\"https:\/\/health.uconn.edu\/structural-biology\/protein-structures\/\">Back to Image Gallery<\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>The Janus-faced atracotoxins are a family of insect-specific excitatory neurotoxins isolated from the venom of Australian funnel-web spiders. In addition to a strikingly asymmetric distribution of charged residues, from which their name is derived, they contain an extremely rare vicinal disulfide bond which is essential for neurotoxic activity. The toxins are selective for insect voltage-gated [&hellip;]<\/p>\n","protected":false},"author":38,"featured_media":0,"parent":155,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-03 23:00:37","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/pages\/238"}],"collection":[{"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/users\/38"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/comments?post=238"}],"version-history":[{"count":7,"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/pages\/238\/revisions"}],"predecessor-version":[{"id":552,"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/pages\/238\/revisions\/552"}],"up":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/pages\/155"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/media?parent=238"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}