{"id":204,"date":"2017-10-31T13:26:41","date_gmt":"2017-10-31T17:26:41","guid":{"rendered":"https:\/\/health.uconn.edu\/structural-biology\/?page_id=204"},"modified":"2017-11-03T15:45:19","modified_gmt":"2017-11-03T19:45:19","slug":"n-terminal-dna-binding-domain-of-xrcc1","status":"publish","type":"page","link":"https:\/\/health.uconn.edu\/structural-biology\/protein-structures\/n-terminal-dna-binding-domain-of-xrcc1\/","title":{"rendered":"N-terminal DNA-binding domain of XRCC1"},"content":{"rendered":"<div id=\"pl-204\"  class=\"panel-layout\" ><div id=\"pg-204-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-204-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-204-0-0-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"0\" ><div class=\"textwidget\"><p><div style=\"width: 400px;\" class=\"wp-video\"><!--[if lt IE 9]><script>document.createElement('video');<\/script><![endif]-->\n<video class=\"wp-video-shortcode\" id=\"video-204-1\" width=\"400\" height=\"360\" loop=\"1\" autoplay=\"1\" preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"https:\/\/health.uconn.edu\/structural-biology\/wp-content\/uploads\/sites\/177\/2017\/11\/N-Terminal-Xrcc1-1.mp4?_=1\" \/><a href=\"https:\/\/health.uconn.edu\/structural-biology\/wp-content\/uploads\/sites\/177\/2017\/11\/N-Terminal-Xrcc1-1.mp4\">https:\/\/health.uconn.edu\/structural-biology\/wp-content\/uploads\/sites\/177\/2017\/11\/N-Terminal-Xrcc1-1.mp4<\/a><\/video><\/div><\/p>\n<\/div><\/div><\/div><div id=\"pgc-204-0-1\"  class=\"panel-grid-cell\" ><div class=\"panel-cell-style panel-cell-style-for-204-0-1\" ><div id=\"panel-204-0-1-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"1\" ><div class=\"textwidget\"><p>DNA damage occurs continuously as a result of processes that include bond hydrolysis, deamination, oxidation, alkylation, free radical damage, and damage due to ionizing radiation. Mammalian cells have developed a multicomponent base excision repair (BER) complex in order to combat these DNA damage events. XRCC1 (X-ray cross-complementing group 1) is a multidomain protein that acts as a scaffold to bring together various components of the BER complex. Each domain of XRCC1 interacts with a different BER component. The N-terminal domain, shown here, interacts with DNA polymerase \u03b2 which is responsible for DNA synthesis at abasic sites.<\/p>\n<hr \/>\n<p>Marintchev, A., Mullen, M.A., Maciejewski, M.W., Pan, B., Gryk, M.R. and Mullen, G.P. (1999) Solution structure of the single-strand break repair protein XRCC1-N-terminal domain.\u00a0<em>Nature Structural Biology<\/em>\u00a06, 884-893.\u00a0<\/p>\n<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=10467102&amp;dopt=Abstract\">PubMed<\/a>\u00a0|\u00a0<a href=\"http:\/\/www.nature.com\/cgi-taf\/DynaPage.taf?file=\/nsb\/journal\/v6\/n9\/abs\/nsb0999_884.html&amp;dynoptions=doi1035926076\" class=\"broken_link\">Journal<\/a>\u00a0|\u00a0<a href=\"http:\/\/www.nature.com\/cgi-taf\/DynaPage.taf?file=\/nsb\/journal\/v6\/n9\/full\/nsb0999_805.html\" class=\"broken_link\">News &amp; Views<\/a>\u00a0|\u00a0<a href=\"http:\/\/www.rcsb.org\/pdb\/cgi\/explore.cgi?pid=44161037810115&amp;pdbId=1XNT\" class=\"broken_link\">PDB Link<\/a><\/p>\n<p><a href=\"https:\/\/health.uconn.edu\/structural-biology\/protein-structures\/\">Back to Image Gallery<\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>DNA damage occurs continuously as a result of processes that include bond hydrolysis, deamination, oxidation, alkylation, free radical damage, and damage due to ionizing radiation. Mammalian cells have developed a multicomponent base excision repair (BER) complex in order to combat these DNA damage events. XRCC1 (X-ray cross-complementing group 1) is a multidomain protein that acts [&hellip;]<\/p>\n","protected":false},"author":38,"featured_media":0,"parent":155,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-01 03:40:23","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/pages\/204"}],"collection":[{"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/users\/38"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/comments?post=204"}],"version-history":[{"count":6,"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/pages\/204\/revisions"}],"predecessor-version":[{"id":560,"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/pages\/204\/revisions\/560"}],"up":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/pages\/155"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/media?parent=204"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}