{"id":195,"date":"2017-10-31T13:21:53","date_gmt":"2017-10-31T17:21:53","guid":{"rendered":"https:\/\/health.uconn.edu\/structural-biology\/?page_id=195"},"modified":"2017-11-03T15:43:26","modified_gmt":"2017-11-03T19:43:26","slug":"n-terminal-dna-binding-domain-of-dna-polymerase-%ce%b2","status":"publish","type":"page","link":"https:\/\/health.uconn.edu\/structural-biology\/protein-structures\/n-terminal-dna-binding-domain-of-dna-polymerase-%ce%b2\/","title":{"rendered":"N-Terminal DNA-Binding Domain of DNA Polymerase \u03b2"},"content":{"rendered":"<div id=\"pl-195\"  class=\"panel-layout\" ><div id=\"pg-195-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-195-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-195-0-0-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"0\" ><div class=\"textwidget\"><p><div style=\"width: 400px;\" class=\"wp-video\"><!--[if lt IE 9]><script>document.createElement('video');<\/script><![endif]-->\n<video class=\"wp-video-shortcode\" id=\"video-195-1\" width=\"400\" height=\"360\" loop=\"1\" autoplay=\"1\" preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"https:\/\/health.uconn.edu\/structural-biology\/wp-content\/uploads\/sites\/177\/2017\/11\/N-Terminal-Polyarmerase-B-1.mp4?_=1\" \/><a href=\"https:\/\/health.uconn.edu\/structural-biology\/wp-content\/uploads\/sites\/177\/2017\/11\/N-Terminal-Polyarmerase-B-1.mp4\">https:\/\/health.uconn.edu\/structural-biology\/wp-content\/uploads\/sites\/177\/2017\/11\/N-Terminal-Polyarmerase-B-1.mp4<\/a><\/video><\/div><\/p>\n<\/div><\/div><\/div><div id=\"pgc-195-0-1\"  class=\"panel-grid-cell\" ><div class=\"panel-cell-style panel-cell-style-for-195-0-1\" ><div id=\"panel-195-0-1-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"1\" ><div class=\"textwidget\"><p>Human DNA is insulted by 10,000 to 1 million damage events per living cell per day. Inefficient repair of DNA damage leads to aging, cancer, and other diseases. DNA polymerase \u03b2 functions in the base excision repair pathway by filling in short patches of damaged DNA and by catalyzing the removal of deoxyribose 5'-phosphate (dRP lyase) from the 5' side of damaged DNA. The N-terminal domain, shown here, binds gapped dsDNA and ssDNA and provides dRP lyase activity.<\/p>\n<hr \/>\n<p>Maciejewski, M.W., Liu, D-J., Prasad, R., Wilson, S.H. and Mullen, G.P. (2000) Backbone dynamics and refined solution structure of the N-terminal domain of DNA polymerase \u03b2. Correlation with DNA binding and dRP lyase activity.\u00a0<em>Journal of Molecular Biology<\/em>\u00a0296, 229-253.<\/p>\n<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=10656829&amp;dopt=Abstract\">PubMed<\/a>\u00a0|\u00a0<a href=\"http:\/\/www.idealibrary.com\/retrieve\/doi\/10.1006\/jmbi.1999.3455\" class=\"broken_link\">Journal<\/a>\u00a0|\u00a0<a href=\"http:\/\/www.rcsb.org\/pdb\/cgi\/explore.cgi?pid=156031037814053&amp;pdbId=1DK3\" class=\"broken_link\">PDB Link<\/a><\/p>\n<p><a href=\"https:\/\/health.uconn.edu\/structural-biology\/protein-structures\/\">Back to Image Gallery<\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Human DNA is insulted by 10,000 to 1 million damage events per living cell per day. Inefficient repair of DNA damage leads to aging, cancer, and other diseases. DNA polymerase \u03b2 functions in the base excision repair pathway by filling in short patches of damaged DNA and by catalyzing the removal of deoxyribose 5&#8242;-phosphate (dRP [&hellip;]<\/p>\n","protected":false},"author":38,"featured_media":0,"parent":155,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-01 22:58:24","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/pages\/195"}],"collection":[{"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/users\/38"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/comments?post=195"}],"version-history":[{"count":8,"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/pages\/195\/revisions"}],"predecessor-version":[{"id":556,"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/pages\/195\/revisions\/556"}],"up":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/pages\/155"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/media?parent=195"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}