{"id":155,"date":"2017-10-31T12:53:05","date_gmt":"2017-10-31T16:53:05","guid":{"rendered":"https:\/\/health.uconn.edu\/structural-biology\/?page_id=155"},"modified":"2017-11-02T12:27:42","modified_gmt":"2017-11-02T16:27:42","slug":"protein-structures","status":"publish","type":"page","link":"https:\/\/health.uconn.edu\/structural-biology\/protein-structures\/","title":{"rendered":"Protein Structures"},"content":{"rendered":"<div id=\"pl-155\"  class=\"panel-layout\" ><div id=\"pg-155-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-155-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-155-0-0-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"0\" ><div class=\"textwidget\"><p>This gallery of protein structures determined at UConn Health NMR Structural Biology Facility provides an overview of the research supported by the facility. In addition to macromolecular structure determination, the facility is used extensively for studies of protein folding, protein dynamics, and mapping of protein-DNA, protein-protein, and protein-ligand interfaces. <strong>Click on a picture for a dynamic image and additional information.<\/strong><\/p>\n<\/div><\/div><\/div><\/div><div id=\"pg-155-1\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-155-1-0\"  class=\"panel-grid-cell\" ><div id=\"panel-155-1-0-0\" class=\"so-panel widget widget_widget_sp_image widget_sp_image panel-first-child panel-last-child\" data-index=\"1\" ><a href=\"https:\/\/health.uconn.edu\/structural-biology\/protein-structures\/dna-polymerase-x\/\" target=\"_self\" class=\"widget_sp_image-image-link\"><img loading=\"lazy\" decoding=\"async\" width=\"125\" height=\"125\" alt=\"DNA Polymerase X\" class=\"attachment-full\" style=\"max-width: 100%;\" src=\"https:\/\/health.uconn.edu\/structural-biology\/wp-content\/uploads\/sites\/177\/2017\/10\/thumb_polx.gif\" \/><\/a><div class=\"widget_sp_image-description\" ><p>DNA Polymerase X<\/p>\n<\/div><\/div><\/div><div id=\"pgc-155-1-1\"  class=\"panel-grid-cell\" ><div id=\"panel-155-1-1-0\" class=\"so-panel widget widget_widget_sp_image widget_sp_image panel-first-child panel-last-child\" data-index=\"2\" ><a href=\"https:\/\/health.uconn.edu\/structural-biology\/protein-structures\/catalytic-domain-of-\u03b3\u03b4-resolvase\/\" target=\"_self\" class=\"widget_sp_image-image-link\"><img loading=\"lazy\" decoding=\"async\" width=\"121\" height=\"125\" alt=\"Catalytic domain of gd resolvase\" class=\"attachment-full\" style=\"max-width: 100%;\" src=\"https:\/\/health.uconn.edu\/structural-biology\/wp-content\/uploads\/sites\/177\/2017\/10\/thumb_resolvase.gif\" \/><\/a><div class=\"widget_sp_image-description\" ><p>Catalytic Domain of gd Resolvase<\/p>\n<\/div><\/div><\/div><div id=\"pgc-155-1-2\"  class=\"panel-grid-cell\" ><div id=\"panel-155-1-2-0\" class=\"so-panel widget widget_widget_sp_image widget_sp_image panel-first-child panel-last-child\" data-index=\"3\" ><a href=\"https:\/\/health.uconn.edu\/structural-biology\/protein-structures\/n-terminal-dna-binding-domain-of-dna-polymerase-%ce%b2\/\" target=\"_self\" class=\"widget_sp_image-image-link\"><img loading=\"lazy\" decoding=\"async\" width=\"125\" height=\"125\" alt=\"N-terminal DNA-binding domain of DNA polymerase \u03b2\" class=\"attachment-full\" style=\"max-width: 100%;\" src=\"https:\/\/health.uconn.edu\/structural-biology\/wp-content\/uploads\/sites\/177\/2017\/10\/thumb_8k.gif\" \/><\/a><div class=\"widget_sp_image-description\" ><p>N-Terminal DNA-Binding Domain of DNA Polymerase \u03b2<\/p>\n<\/div><\/div><\/div><div id=\"pgc-155-1-3\"  class=\"panel-grid-cell\" ><div id=\"panel-155-1-3-0\" class=\"so-panel widget widget_widget_sp_image widget_sp_image panel-first-child panel-last-child\" data-index=\"4\" ><a href=\"https:\/\/health.uconn.edu\/structural-biology\/protein-structures\/n-terminal-dna-binding-domain-of-xrcc1\/\" target=\"_self\" class=\"widget_sp_image-image-link\"><img loading=\"lazy\" decoding=\"async\" width=\"125\" height=\"125\" alt=\"N-terminal DNA-binding domain of XRCC1\" class=\"attachment-full\" style=\"max-width: 100%;\" src=\"https:\/\/health.uconn.edu\/structural-biology\/wp-content\/uploads\/sites\/177\/2017\/10\/thumb_xrcc1.gif\" \/><\/a><div class=\"widget_sp_image-description\" ><p>N-Terminal DNA-Binding Domain of XRCC1<\/p>\n<\/div><\/div><\/div><\/div><div id=\"pg-155-2\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-155-2-0\"  class=\"panel-grid-cell\" ><div id=\"panel-155-2-0-0\" class=\"so-panel widget widget_widget_sp_image widget_sp_image panel-first-child panel-last-child\" data-index=\"5\" ><a href=\"https:\/\/health.uconn.edu\/structural-biology\/topological-specificity-domain-of-mine\/\" target=\"_self\" class=\"widget_sp_image-image-link\"><img loading=\"lazy\" decoding=\"async\" width=\"101\" height=\"125\" alt=\"DNA polymerase X\" class=\"attachment-full\" style=\"max-width: 100%;\" src=\"https:\/\/health.uconn.edu\/structural-biology\/wp-content\/uploads\/sites\/177\/2017\/10\/thumb_mine.jpg\" \/><\/a><div class=\"widget_sp_image-description\" ><p>Topological Specificity Domain of MinE<\/p>\n<\/div><\/div><\/div><div id=\"pgc-155-2-1\"  class=\"panel-grid-cell\" ><div id=\"panel-155-2-1-0\" class=\"so-panel widget widget_widget_sp_image widget_sp_image panel-first-child panel-last-child\" data-index=\"6\" ><a href=\"https:\/\/health.uconn.edu\/structural-biology\/protein-structures\/sda-a-novel-checkpoint-control-kinase-inhibitor\/\" target=\"_self\" class=\"widget_sp_image-image-link\"><img loading=\"lazy\" decoding=\"async\" width=\"119\" height=\"125\" alt=\"Catalytic domain of gd resolvase\" class=\"attachment-full\" style=\"max-width: 100%;\" src=\"https:\/\/health.uconn.edu\/structural-biology\/wp-content\/uploads\/sites\/177\/2017\/10\/thumb_sda.gif\" \/><\/a><div class=\"widget_sp_image-description\" ><p>Sda, a Novel Checkpoint Control Kinase Inhibitor<\/p>\n<\/div><\/div><\/div><div id=\"pgc-155-2-2\"  class=\"panel-grid-cell\" ><div id=\"panel-155-2-2-0\" class=\"so-panel widget widget_widget_sp_image widget_sp_image panel-first-child panel-last-child\" data-index=\"7\" ><a href=\"https:\/\/health.uconn.edu\/structural-biology\/protein-structures\/chlamydomonas-outer-arm-dynein-light-chain-1\/\" target=\"_self\" class=\"widget_sp_image-image-link\"><img loading=\"lazy\" decoding=\"async\" width=\"70\" height=\"125\" alt=\"N-terminal DNA-binding domain of DNA polymerase \u03b2\" class=\"attachment-full\" style=\"max-width: 100%;\" src=\"https:\/\/health.uconn.edu\/structural-biology\/wp-content\/uploads\/sites\/177\/2017\/10\/thumb_lc1.gif\" \/><\/a><div class=\"widget_sp_image-description\" ><p>Dynein Light Chain 1<\/p>\n<\/div><\/div><\/div><div id=\"pgc-155-2-3\"  class=\"panel-grid-cell\" ><div id=\"panel-155-2-3-0\" class=\"so-panel widget widget_widget_sp_image widget_sp_image panel-first-child panel-last-child\" data-index=\"8\" ><a href=\"https:\/\/health.uconn.edu\/structural-biology\/protein-structures\/janus-faced-atracotoxin-a-blocker-of-insect-potassium-channels\/\" target=\"_self\" class=\"widget_sp_image-image-link\"><img loading=\"lazy\" decoding=\"async\" width=\"81\" height=\"125\" alt=\"N-terminal DNA-binding domain of XRCC1\" class=\"attachment-full\" style=\"max-width: 100%;\" src=\"https:\/\/health.uconn.edu\/structural-biology\/wp-content\/uploads\/sites\/177\/2017\/10\/thumb_jpharmacophore.gif\" \/><\/a><div class=\"widget_sp_image-description\" ><p>Janus-Faced Atracotoxin, a Blocker of Insect Potassium Channels<\/p>\n<\/div><\/div><\/div><\/div><div id=\"pg-155-3\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-155-3-0\"  class=\"panel-grid-cell\" ><div id=\"panel-155-3-0-0\" class=\"so-panel widget widget_widget_sp_image widget_sp_image panel-first-child panel-last-child\" data-index=\"9\" ><a href=\"https:\/\/health.uconn.edu\/structural-biology\/protein-structures\/%cf%89-atracotoxin-2-a-blocker-of-insect-calcium-channels\/\" target=\"_self\" class=\"widget_sp_image-image-link\"><img loading=\"lazy\" decoding=\"async\" width=\"125\" height=\"125\" alt=\"DNA polymerase X\" class=\"attachment-full\" style=\"max-width: 100%;\" src=\"https:\/\/health.uconn.edu\/structural-biology\/wp-content\/uploads\/sites\/177\/2017\/10\/thumb_hv2a.gif\" \/><\/a><div class=\"widget_sp_image-description\" ><p>\u03c9-Atracotoxin-2, a Blocker of Insect Calcium Channels<\/p>\n<\/div><\/div><\/div><div id=\"pgc-155-3-1\"  class=\"panel-grid-cell\" ><div id=\"panel-155-3-1-0\" class=\"so-panel widget widget_widget_sp_image widget_sp_image panel-first-child panel-last-child\" data-index=\"10\" ><a href=\"https:\/\/health.uconn.edu\/structural-biology\/protein-structures\/agrin-g3\/\" target=\"_self\" class=\"widget_sp_image-image-link\"><img loading=\"lazy\" decoding=\"async\" width=\"125\" height=\"125\" alt=\"Catalytic domain of gd resolvase\" class=\"attachment-full\" style=\"max-width: 100%;\" src=\"https:\/\/health.uconn.edu\/structural-biology\/wp-content\/uploads\/sites\/177\/2017\/10\/thumb_agrin.gif\" \/><\/a><div class=\"widget_sp_image-description\" ><p>Agrin-G3<\/p>\n<\/div><\/div><\/div><div id=\"pgc-155-3-2\"  class=\"panel-grid-cell\" ><div id=\"panel-155-3-2-0\" class=\"so-panel widget widget_widget_sp_image widget_sp_image panel-first-child panel-last-child\" data-index=\"11\" ><a href=\"https:\/\/health.uconn.edu\/structural-biology\/protein-structures\/dark-adapted-form-of-bovine-rhodopsin\/\" target=\"_self\" class=\"widget_sp_image-image-link\"><img loading=\"lazy\" decoding=\"async\" width=\"118\" height=\"125\" alt=\"N-terminal DNA-binding domain of DNA polymerase \u03b2\" class=\"attachment-full\" style=\"max-width: 100%;\" src=\"https:\/\/health.uconn.edu\/structural-biology\/wp-content\/uploads\/sites\/177\/2017\/10\/thumb_rhodopsin.gif\" \/><\/a><div class=\"widget_sp_image-description\" ><p>Dark-Adapted Form of Bovine Rhodopsin<\/p>\n<\/div><\/div><\/div><div id=\"pgc-155-3-3\"  class=\"panel-grid-cell\" ><div id=\"panel-155-3-3-0\" class=\"so-panel widget widget_widget_sp_image widget_sp_image panel-first-child panel-last-child\" data-index=\"12\" ><a href=\"https:\/\/health.uconn.edu\/structural-biology\/protein-structures\/lsiii-a-neurotoxin-from-the-venom-of-laticauda-semifasciata\/\" target=\"_self\" class=\"widget_sp_image-image-link\"><img loading=\"lazy\" decoding=\"async\" width=\"90\" height=\"125\" alt=\"N-terminal DNA-binding domain of XRCC1\" class=\"attachment-full\" style=\"max-width: 100%;\" src=\"https:\/\/health.uconn.edu\/structural-biology\/wp-content\/uploads\/sites\/177\/2017\/10\/thumb_1lsi.gif\" \/><\/a><div class=\"widget_sp_image-description\" ><p>LSIII, a Neurotoxin that Blocks the Nicotinic Acetylcholine Receptor<\/p>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>This gallery of protein structures determined at UConn Health NMR Structural Biology Facility provides an overview of the research supported by the facility. In addition to macromolecular structure determination, the facility is used extensively for studies of protein folding, protein dynamics, and mapping of protein-DNA, protein-protein, and protein-ligand interfaces. Click on a picture for a [&hellip;]<\/p>\n","protected":false},"author":38,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-11 21:01:30","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/pages\/155"}],"collection":[{"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/users\/38"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/comments?post=155"}],"version-history":[{"count":55,"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/pages\/155\/revisions"}],"predecessor-version":[{"id":411,"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/pages\/155\/revisions\/411"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/structural-biology\/wp-json\/wp\/v2\/media?parent=155"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}