{"id":407,"date":"2020-07-15T23:41:06","date_gmt":"2020-07-16T03:41:06","guid":{"rendered":"https:\/\/health.uconn.edu\/stem-cell-core\/?page_id=407"},"modified":"2020-07-15T23:41:06","modified_gmt":"2020-07-16T03:41:06","slug":"uconn-stem-cell-core-hipscs","status":"publish","type":"page","link":"https:\/\/health.uconn.edu\/stem-cell-core\/uconn-stem-cell-core-hipscs\/","title":{"rendered":"UConn Stem Cell Core hiPSCs"},"content":{"rendered":"

UConn Stem Cell Core iPSCs<\/h3>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Cell Line Name<\/strong><\/td>\nOther names<\/strong><\/td>\nSample<\/strong><\/td>\nMethod\/Factors<\/strong><\/p>\n

 <\/td>\n

Publications or Notes on method<\/strong><\/td>\nXX or XY<\/strong><\/td>\nKaryotype<\/strong><\/td>\nAvailability<\/strong><\/td>\n<\/tr>\n<\/thead>\n
UCH-HF-YK-27<\/td>\nHDFa-YK27, YK27<\/td>\nHuman dermal fibroblast line hDFa<\/td>\nRetroviral, see\u00a0 Martins-Taylor, et al., 2011<\/td>\nMartins-Taylor, et al., 2011\u00a0 Reference<\/a><\/td>\nXX<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
UCH-HF-YK-26<\/td>\nHDFa-YK26, YK26<\/td>\nHuman dermal fibroblast line hDFa<\/td>\nRetroviral, see\u00a0 Martins-Taylor, et al., 2011<\/td>\nMartins-Taylor, et al., 2011\u00a0 Reference<\/a><\/td>\nXX<\/td>\nYes<\/td>\nYes, high passage only<\/td>\n<\/tr>\n
UCH-HF-TZ-1<\/td>\nIMR90-TZ1, TZ-1<\/td>\nHuman fetal lung fibroblast line IMR90<\/td>\nLentiviral, see\u00a0 Martins-Taylor, et al., 2011<\/td>\nZeng, et al., 2010\u00a0 Reference<\/a><\/td>\nXX<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
UCH-HF-47-<\/td>\nRX47I-RIP1, RiP1, RX47<\/td>\nHuman neonatal foreskin fibroblast line BJ<\/td>\nmRNA\/OCT4, SOX2, KLF4, C-MYC, and LIN28<\/td>\nStemgent Inc. method and fibroblasts\u00a0 Reference<\/a><\/td>\nXY<\/td>\nYes<\/td>\nYes, needs scale up<\/td>\n<\/tr>\n
UCH-CBLR-48A-<\/td>\nCBLR, RX48A,\u00a0 CB-iPS-lenti<\/td>\nHuman cord blood MNC. Lonza<\/td>\nstemcca \u2013 lentiviral<\/td>\nVector by G. Mostoslavsky\u00a0 Reference<\/a><\/td>\nXX<\/td>\nYes<\/td>\nYes, needs scale up<\/td>\n<\/tr>\n
UCH-CBY4-48B-<\/td>\nCBY4, RX48B,\u00a0 CB-iPS-epi<\/td>\nHuman cord blood MNC, Lonza<\/td>\nEpisomal\/ OCT4, SOX2, KLF4, L-MYC, LIN28, and P53-shRNA<\/td>\nMethod by S. Yamanaka\u00a0 Reference<\/a><\/td>\nXX<\/td>\nYes<\/td>\nYes, needs scale up<\/td>\n<\/tr>\n
UCH-PBY4-48D-<\/td>\nPBY4, RX48D,\u00a0 PB-iPS<\/td>\nHuman peripheral blood MNC<\/td>\nEpisomal\/ OCT4, SOX2, KLF4, L-MYC, LIN28, and P53-shRNA<\/td>\nMethod by S. Yamanaka\u00a0Reference<\/a><\/td>\nXY<\/td>\nYes<\/td>\nYes, needs scale up<\/td>\n<\/tr>\n
UCH-HF-49A-<\/td>\nHFY4, RX49A,\u00a0 hFib_epi<\/td>\nHuman adult skin fibroblasts, Lonza<\/td>\nEpisomal\/ OCT4, SOX2, KLF4, L-MYC, LIN28, and P53-shRNA<\/td>\nMethod by S. Yamanaka\u00a0Reference<\/a><\/td>\nXX<\/td>\nYes<\/td>\nYes, needs scale up<\/td>\n<\/tr>\n
UCH-PB-48E-<\/td>\nPB-BD1-Y4,\u00a0 PB-iPS-BD1,<\/p>\n

RX48E<\/td>\n

Peripheral blood from draw<\/td>\nEpisomal\/ OCT4, SOX2, KLF4, L-MYC, LIN28, and P53-shRNA<\/td>\nMethod by S. Yamanaka\u00a0Reference<\/a><\/td>\nXY<\/td>\nYes<\/td>\nYes, needs scale up<\/td>\n<\/tr>\n
UCH-HF-121-<\/td>\nBJY4 FF (feeder free),\u00a0 RX121<\/td>\nHuman neonatal foreskin fibroblast line BJ, ATCC<\/td>\nEpisomal\/ OCT4, SOX2, KLF4, L-MYC, LIN28, and P53-shRNA<\/td>\nDerived in E7, E8, matrigel, frozen in mFreSR. Vectors by S. Yamanaka\u00a0Reference<\/a><\/td>\nXY<\/td>\nNo<\/td>\nYes, needs thaw, scale up, karyotype<\/td>\n<\/tr>\n
UCH-HF-63-<\/td>\nBJSV,\u00a0 RX63<\/td>\nHuman neonatal foreskin fibroblast line BJ, ATCC<\/td>\nCytotune Sendai Virus, OSKM<\/td>\nMethod\u00a0 Reference<\/a> (Version 1)<\/td>\nXY<\/td>\nNo<\/td>\nYes, needs thaw, scale up, karyotype<\/td>\n<\/tr>\n
UCH-HF-12-<\/td>\nBJRV,\u00a0 RX12<\/td>\nHuman neonatal foreskin fibroblast line BJ<\/td>\nretroviral<\/td>\nOSKML<\/td>\nXY<\/td>\nNo<\/td>\nYes, needs thaw, scale up, karyotype<\/td>\n<\/tr>\n
UCH-HF-13-<\/td>\nBJLV,\u00a0 RX13<\/td>\nHuman neonatal foreskin fibroblast line BJ<\/td>\nstemcca – lentiviral<\/td>\nVector by G. Mostoslavsky\u00a0 Reference<\/a><\/td>\nXY<\/td>\nYes<\/td>\nYes, needs thaw, scale up, karyotype<\/td>\n<\/tr>\n
UCH-HF-YZ-1<\/td>\nIMR90-YZ1, YZ-1<\/td>\nHuman fetal lung fibroblast line IMR90<\/td>\nRetroviral, see\u00a0 Martins-Taylor, et al., 2011<\/td>\nMartins-Taylor, et al., 2011\u00a0 Reference<\/a><\/td>\nXX<\/td>\nNo<\/td>\nYes, needs thaw, scale up, karyotype<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

About the iPSC Names<\/h3>\n

UCH-[internal descriptor]-[log number]-[clone number, may be blank]<\/p>\n

UCH = UConn Health<\/p>\n

Please contact us to request hiPSCs from UConn Stem Cell Core., or with questions about our hiPSC lines.<\/p>\n

Sample of publications using UConn Stem Cell Core iPSCs<\/h3>\n

Specification of region-specific neurons including forebrain glutamatergic neurons from human induced pluripotent stem cells<\/a><\/p>\n

Efficient differentiation of human iPSC\u2010derived mesenchymal stem cells to chondroprogenitor cells<\/a><\/p>\n

The familial Alzheimer’s disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons<\/a><\/p>\n

One-step derivation of mesenchymal stem cell (MSC)-like cells from human pluripotent stem cells on a fibrillar collagen coating<\/a><\/p>\n

Establishment of human cell type-specific iPS cells with enhanced chondrogenic potential<\/a><\/p>\n

Modified hyaluronan hydrogels support the maintenance of mouse embryonic stem cells and human induced pluripotent stem cells<\/a><\/p>\n

Human pluripotent stem cells have a novel mismatch repair-dependent damage response<\/a><\/p>\n

Comparison and optimization of hiPSC forebrain cortical differentiation protocols<\/a><\/p>\n

Single-Cell Detection of Secreted A\u03b2 and sAPP\u03b1 from Human IPSC-Derived Neurons and Astrocytes<\/a><\/p>\n

Role of DNMT3B in the regulation of early neural and neural crest specifiers<\/a><\/p>\n

Concise review: genomic stability of human induced pluripotent stem cells<\/a><\/p>\n

Vaccination with human pluripotent stem cells generates a broad spectrum of immunological and clinical responses against colon cancer<\/a><\/p>\n

Inhibition of caspase-mediated anoikis is critical for basic fibroblast growth factor-sustained culture of human pluripotent stem cells<\/a><\/p>\n

The Balance of Positive and Negative Effects of TGF-\u03b2 Signaling Regulates the Development of Hematopoietic and Endothelial Progenitors in Human Pluripotent Stem Cells <\/a><\/p>\n

Cooperative Effect of Erythropoietin and TGF\u2010\u03b2 Inhibition on Erythroid Development in Human Pluripotent Stem Cells<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

UConn Stem Cell Core iPSCs Cell Line Name Other names Sample Method\/Factors   Publications or Notes on method XX or XY Karyotype Availability UCH-HF-YK-27 HDFa-YK27, YK27 Human dermal fibroblast line hDFa Retroviral, see\u00a0 Martins-Taylor, et al., 2011 Martins-Taylor, et al., 2011\u00a0 Reference XX Yes Yes UCH-HF-YK-26 HDFa-YK26, YK26 Human dermal fibroblast line hDFa Retroviral, see\u00a0 […]<\/p>\n","protected":false},"author":2118,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-blank.php","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-26 16:29:28","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/stem-cell-core\/wp-json\/wp\/v2\/pages\/407"}],"collection":[{"href":"https:\/\/health.uconn.edu\/stem-cell-core\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/health.uconn.edu\/stem-cell-core\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/stem-cell-core\/wp-json\/wp\/v2\/users\/2118"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/stem-cell-core\/wp-json\/wp\/v2\/comments?post=407"}],"version-history":[{"count":4,"href":"https:\/\/health.uconn.edu\/stem-cell-core\/wp-json\/wp\/v2\/pages\/407\/revisions"}],"predecessor-version":[{"id":412,"href":"https:\/\/health.uconn.edu\/stem-cell-core\/wp-json\/wp\/v2\/pages\/407\/revisions\/412"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/stem-cell-core\/wp-json\/wp\/v2\/media?parent=407"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}