{"id":509,"date":"2017-05-16T14:37:03","date_gmt":"2017-05-16T18:37:03","guid":{"rendered":"https:\/\/health.uconn.edu\/spirochete-lab\/lyme-disease-research\/publications-2\/"},"modified":"2025-09-02T17:38:37","modified_gmt":"2025-09-02T21:38:37","slug":"leptospirosis-publications","status":"publish","type":"page","link":"https:\/\/health.uconn.edu\/spirochete-lab\/leptospirosis-research\/leptospirosis-publications\/","title":{"rendered":"Leptospirosis Research Publications"},"content":{"rendered":"<div class=\"in-page-tabs\"><ul id=\"menu-leptospirosis-subnav\" class=\"menu nav nav-tabs\"><li id=\"menu-item-550\" class=\"menu-item menu-item-type-post_type menu-item-object-page\"><a href=\"https:\/\/health.uconn.edu\/spirochete-lab\/leptospirosis-research\/leptospirosis-research\/\">Leptospirosis Research<\/a><\/li><li id=\"menu-item-545\" class=\"menu-item menu-item-type-post_type menu-item-object-page\"><a href=\"https:\/\/health.uconn.edu\/spirochete-lab\/leptospirosis-research\/leptospirosis-team\/\">Leptospirosis Research Team<\/a><\/li><li id=\"menu-item-546\" class=\"menu-item menu-item-type-post_type menu-item-object-page\"><a href=\"https:\/\/health.uconn.edu\/spirochete-lab\/leptospirosis-research\/leptospirosis-collaborations\/\">Leptospirosis Collaborations<\/a><\/li><li id=\"menu-item-547\" class=\"menu-item menu-item-type-post_type menu-item-object-page\"><a href=\"https:\/\/health.uconn.edu\/spirochete-lab\/leptospirosis-research\/leptospirosis-publications\/\">Leptospirosis Publications<\/a><\/li><\/ul><\/div><div id=\"pl-509\"  class=\"panel-layout\" ><div id=\"pg-509-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-509-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-509-0-0-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"0\" ><div class=\"textwidget\"><h5>Leptospirosis Research<\/h5>\n<h1>Publications<\/h1>\n<\/div><\/div><\/div><\/div><div id=\"pg-509-1\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-509-1-0\"  class=\"panel-grid-cell\" ><div id=\"panel-509-1-0-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"1\" ><div class=\"textwidget\"><h2>Selected Leptospirosis Publications<\/h2>\n<ul>\n<li data-start=\"1061\" data-end=\"1348\">\n<p data-start=\"1063\" data-end=\"1348\">Bettin EB, Grassmann AA, Dellagostin OA, Gogarten JP, Caimano MJ. <strong data-start=\"1129\" data-end=\"1243\">Leptospira interrogans encodes a canonical BamA and three novel noNterm Omp85 outer membrane protein paralogs.<\/strong> <em data-start=\"1244\" data-end=\"1254\">Sci Rep.<\/em> 2024;14(1):19958. PMID: 39198480; PMCID: PMC11358297. <span class=\"\" data-state=\"closed\"><span class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\" data-testid=\"webpage-citation-pill\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39198480\/\" target=\"_blank\" rel=\"noopener\" alt=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39198480\/\" class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\"><span class=\"max-w-full grow truncate overflow-hidden text-center\">PubMed<\/span><\/span><\/span><\/a><\/span><\/span><\/p>\n<\/li>\n<li data-start=\"1349\" data-end=\"1647\">\n<p data-start=\"1351\" data-end=\"1647\">Maia MAC, Bettin EB, Barbosa LN, <em data-start=\"1384\" data-end=\"1392\">et al.<\/em> <strong data-start=\"1393\" data-end=\"1525\">Challenges for the development of a universal vaccine against leptospirosis revealed by the evaluation of 22 vaccine candidates.<\/strong> <em data-start=\"1526\" data-end=\"1556\">Front Cell Infect Microbiol.<\/em> 2022;12:940966. PMID: 36275031; PMCID: PMC9586249. <span class=\"\" data-state=\"closed\"><span class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\" data-testid=\"webpage-citation-pill\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36275031\/\" target=\"_blank\" rel=\"noopener\" alt=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36275031\/\" class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\"><span class=\"max-w-full grow truncate overflow-hidden text-center\">PubMed<\/span><\/span><\/span><\/a><\/span><\/span><\/p>\n<\/li>\n<li data-start=\"1648\" data-end=\"1956\">\n<p data-start=\"1650\" data-end=\"1956\">Bettin EB, Dorneles J, Hecktheuer AS, <em data-start=\"1688\" data-end=\"1696\">et al.<\/em> <strong data-start=\"1697\" data-end=\"1831\">TonB-dependent receptor epitopes expressed in <em data-start=\"1745\" data-end=\"1755\">M. bovis<\/em> BCG induced significant protection in the hamster model of leptospirosis.<\/strong> <em data-start=\"1832\" data-end=\"1860\">Appl Microbiol Biotechnol.<\/em> 2022;106(1):173\u2013184. PMID: 34893930; PMCID: PMC8664668. <span class=\"\" data-state=\"closed\"><span class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\" data-testid=\"webpage-citation-pill\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34893930\/\" target=\"_blank\" rel=\"noopener\" alt=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34893930\/\" class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\"><span class=\"max-w-full grow truncate overflow-hidden text-center\">PubMed<\/span><\/span><\/span><\/a><\/span><\/span><\/p>\n<\/li>\n<li data-start=\"1957\" data-end=\"2289\">\n<p data-start=\"1959\" data-end=\"2289\">Grassmann AA, Zavala-Alvarado C, Bettin EB, <em data-start=\"2003\" data-end=\"2011\">et al.<\/em> <strong data-start=\"2012\" data-end=\"2177\">The FUR-like regulators PerRA and PerRB integrate a complex regulatory network that promotes mammalian host-adaptation and virulence of <em data-start=\"2150\" data-end=\"2174\">Leptospira interrogans<\/em>.<\/strong><em data-start=\"2178\" data-end=\"2192\">PLoS Pathog.<\/em> 2021;17(12):e1009078. PMID: 34855918; PMCID: PMC8638967. <span class=\"\" data-state=\"closed\"><span class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\" data-testid=\"webpage-citation-pill\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34855918\/\" target=\"_blank\" rel=\"noopener\" alt=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34855918\/\" class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\"><span class=\"max-w-full grow truncate overflow-hidden text-center\">PubMed<\/span><\/span><\/span><\/a><\/span><\/span><\/p>\n<\/li>\n<li data-start=\"2290\" data-end=\"2506\">\n<p data-start=\"2292\" data-end=\"2506\">Grassmann AA, Caimano MJ. <strong data-start=\"2318\" data-end=\"2411\">Cultivation of <em data-start=\"2335\" data-end=\"2359\">Leptospira interrogans<\/em> Within Rat Peritoneal Dialysis Membrane Chambers.<\/strong> <em data-start=\"2412\" data-end=\"2431\">Methods Mol Biol.<\/em> 2020;2134:229\u2013242. PMID: 32632874. <span class=\"\" data-state=\"closed\"><span class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\" data-testid=\"webpage-citation-pill\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32632874\/\" target=\"_blank\" rel=\"noopener\" alt=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32632874\/\" class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\"><span class=\"max-w-full grow truncate overflow-hidden text-center\">PubMed<\/span><\/span><\/span><\/a><\/span><\/span><\/p>\n<\/li>\n<li data-start=\"2507\" data-end=\"2802\">\n<p data-start=\"2509\" data-end=\"2802\">Nally JE, Grassmann AA, Planchon S, <em data-start=\"2545\" data-end=\"2553\">et al.<\/em> <strong data-start=\"2554\" data-end=\"2684\">Pathogenic leptospires modulate protein expression and post-translational modifications in response to mammalian host signals.<\/strong> <em data-start=\"2685\" data-end=\"2715\">Front Cell Infect Microbiol.<\/em> 2017;7:362. PMID: 28848720; PMCID: PMC5553009. <span class=\"\" data-state=\"closed\"><span class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\" data-testid=\"webpage-citation-pill\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28848720\/\" target=\"_blank\" rel=\"noopener\" alt=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28848720\/\" class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\"><span class=\"max-w-full grow truncate overflow-hidden text-center\">PubMed<\/span><\/span><\/span><\/a><\/span><\/span><\/p>\n<\/li>\n<li data-start=\"2803\" data-end=\"3055\">\n<p data-start=\"2805\" data-end=\"3055\">Grassmann AA, Kremer FS, Dos Santos JC, <em data-start=\"2845\" data-end=\"2853\">et al.<\/em> <strong data-start=\"2854\" data-end=\"2951\">Discovery of novel leptospirosis vaccine candidates using reverse and structural vaccinology.<\/strong> <em data-start=\"2952\" data-end=\"2968\">Front Immunol.<\/em> 2017;8:463. PMID: 28496441; PMCID: PMC5406399. <span class=\"\" data-state=\"closed\"><span class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\" data-testid=\"webpage-citation-pill\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28496441\/\" target=\"_blank\" rel=\"noopener\" alt=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28496441\/\" class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\"><span class=\"max-w-full grow truncate overflow-hidden text-center\">PubMed<\/span><\/span><\/span><\/a><\/span><\/span><\/p>\n<\/li>\n<li data-start=\"3056\" data-end=\"3282\">\n<p data-start=\"3058\" data-end=\"3282\">Grassmann AA, Souza JD, McBride AJA. <strong data-start=\"3095\" data-end=\"3178\">A universal vaccine against leptospirosis: Are we going in the right direction?<\/strong> <em data-start=\"3179\" data-end=\"3195\">Front Immunol.<\/em> 2017;8:256. PMID: 28337203; PMCID: PMC5343615. <span class=\"\" data-state=\"closed\"><span class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\" data-testid=\"webpage-citation-pill\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28337203\/\" target=\"_blank\" rel=\"noopener\" alt=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28337203\/\" class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\"><span class=\"max-w-full grow truncate overflow-hidden text-center\">PubMed<\/span><\/span><\/span><\/a><\/span><\/span><\/p>\n<\/li>\n<li data-start=\"3283\" data-end=\"3525\">\n<p data-start=\"3285\" data-end=\"3525\">Dellagostin OA, Grassmann AA, Rizzi C, <em data-start=\"3324\" data-end=\"3332\">et al.<\/em> <strong data-start=\"3333\" data-end=\"3417\">Reverse vaccinology: An approach for identifying leptospiral vaccine candidates.<\/strong> <em data-start=\"3418\" data-end=\"3434\">Int J Mol Sci.<\/em> 2017;18(1):158. PMID: 28098813; PMCID: PMC5297791. <span class=\"\" data-state=\"closed\"><span class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\" data-testid=\"webpage-citation-pill\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28098813\/\" target=\"_blank\" rel=\"noopener\" alt=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28098813\/\" class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\"><span class=\"max-w-full grow truncate overflow-hidden text-center\">PubMed<\/span><\/span><\/span><\/a><\/span><\/span><\/p>\n<\/li>\n<li data-start=\"3526\" data-end=\"3852\">\n<p data-start=\"3528\" data-end=\"3852\">Caimano MJ, Sivasankaran SK, Allard A, <em data-start=\"3567\" data-end=\"3575\">et al.<\/em> <strong data-start=\"3576\" data-end=\"3743\">A model system for studying the transcriptomic and physiological changes associated with mammalian host-adaptation by <em data-start=\"3696\" data-end=\"3720\">Leptospira interrogans<\/em> serovar Copenhageni.<\/strong> <em data-start=\"3744\" data-end=\"3758\">PLoS Pathog.<\/em> 2014;10(3):e1004004. PMID: 24626166; PMCID: PMC3953431. <span class=\"\" data-state=\"closed\"><span class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\" data-testid=\"webpage-citation-pill\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24626166\/\" target=\"_blank\" rel=\"noopener\" alt=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24626166\/\" class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\"><span class=\"max-w-full grow truncate overflow-hidden text-center\">PubMed<\/span><\/span><\/span><\/a><\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Leptospirosis Research Publications Selected Leptospirosis Publications Bettin EB, Grassmann AA, Dellagostin OA, Gogarten JP, Caimano MJ. Leptospira interrogans encodes a canonical BamA and three novel noNterm Omp85 outer membrane protein paralogs. Sci Rep. 2024;14(1):19958. PMID: 39198480; PMCID: PMC11358297. PubMed Maia MAC, Bettin EB, Barbosa LN, et al. Challenges for the development of a universal vaccine [&hellip;]<\/p>\n","protected":false},"author":38,"featured_media":0,"parent":505,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-blank.php","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-01 07:46:34","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/spirochete-lab\/wp-json\/wp\/v2\/pages\/509"}],"collection":[{"href":"https:\/\/health.uconn.edu\/spirochete-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/health.uconn.edu\/spirochete-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/spirochete-lab\/wp-json\/wp\/v2\/users\/38"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/spirochete-lab\/wp-json\/wp\/v2\/comments?post=509"}],"version-history":[{"count":2,"href":"https:\/\/health.uconn.edu\/spirochete-lab\/wp-json\/wp\/v2\/pages\/509\/revisions"}],"predecessor-version":[{"id":529,"href":"https:\/\/health.uconn.edu\/spirochete-lab\/wp-json\/wp\/v2\/pages\/509\/revisions\/529"}],"up":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/spirochete-lab\/wp-json\/wp\/v2\/pages\/505"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/spirochete-lab\/wp-json\/wp\/v2\/media?parent=509"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}