{"id":12,"date":"2017-05-16T11:36:47","date_gmt":"2017-05-16T15:36:47","guid":{"rendered":"https:\/\/health.uconn.edu\/spirochete-lab\/?page_id=12"},"modified":"2025-09-02T17:46:42","modified_gmt":"2025-09-02T21:46:42","slug":"lyme-research","status":"publish","type":"page","link":"https:\/\/health.uconn.edu\/spirochete-lab\/lyme-disease-research\/lyme-research\/","title":{"rendered":"Lyme Disease Research"},"content":{"rendered":"<div class=\"in-page-tabs\"><ul id=\"menu-lyme-disease\" class=\"menu nav nav-tabs\"><li id=\"menu-item-131\" class=\"menu-item menu-item-type-post_type menu-item-object-page\"><a href=\"https:\/\/health.uconn.edu\/spirochete-lab\/lyme-disease-research\/lyme-research\/\">Lyme Disease Research<\/a><\/li><li id=\"menu-item-128\" class=\"menu-item menu-item-type-post_type menu-item-object-page\"><a href=\"https:\/\/health.uconn.edu\/spirochete-lab\/lyme-disease-research\/lyme-team\/\">Lyme Disease Research Team<\/a><\/li><li id=\"menu-item-129\" class=\"menu-item menu-item-type-post_type menu-item-object-page\"><a href=\"https:\/\/health.uconn.edu\/spirochete-lab\/lyme-disease-research\/lyme-disease-collaborations\/\">Lyme Disease Collaborations<\/a><\/li><li id=\"menu-item-130\" class=\"menu-item menu-item-type-post_type menu-item-object-page\"><a href=\"https:\/\/health.uconn.edu\/spirochete-lab\/lyme-disease-research\/lyme-publications\/\">Lyme Disease Publications<\/a><\/li><\/ul><\/div><div id=\"pl-12\"  class=\"panel-layout\" ><div id=\"pg-12-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-12-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-12-0-0-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"0\" ><div class=\"textwidget\"><h5>Lyme Disease Research<\/h5>\n<h1>Research<\/h1>\n<\/div><\/div><\/div><\/div><div id=\"pg-12-1\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-12-1-0\"  class=\"panel-grid-cell\" ><div id=\"panel-12-1-0-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"1\" ><div class=\"textwidget\"><h2>Lyme Disease Research - <em>Borrelia burgdorferi<img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-103\" src=\"https:\/\/health.uconn.edu\/spirochete-lab\/wp-content\/uploads\/sites\/133\/2017\/05\/photo-1_507x338.jpg\" alt=\"Ticks in a jar\" width=\"450\" height=\"300\" srcset=\"https:\/\/health.uconn.edu\/spirochete-lab\/wp-content\/uploads\/sites\/133\/2017\/05\/photo-1_507x338.jpg 507w, https:\/\/health.uconn.edu\/spirochete-lab\/wp-content\/uploads\/sites\/133\/2017\/05\/photo-1_507x338-300x200.jpg 300w, https:\/\/health.uconn.edu\/spirochete-lab\/wp-content\/uploads\/sites\/133\/2017\/05\/photo-1_507x338-272x182.jpg 272w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><\/em><\/h2>\n<p><span>Lyme disease is the most common vector-borne infection in the United States, with Connecticut at the epicenter of its public health burden. Our group investigates how <\/span><em data-start=\"453\" data-end=\"469\">B. burgdorferi<\/em><span>, the Lyme disease spirochete, adapts as it cycles between ticks and mammals. Using conventional RNA-seq and advanced capture RNA-seq, we analyze how the alternative sigma factor RpoS coordinates with other regulators to reprogram the transcriptome in environment-specific ways\u2014activating genes during tick-to-mouse transmission and mammalian infection, while repressing tick-phase genes in the mammalian host. Current work dissects how the Fur-family regulator BosR and the c-di-GMP receptor PlzA function as reciprocal modulators of RpoS: BosR enables both activation and repression at RpoS-dependent promoters, whereas ligand-bound PlzA relieves RpoS-mediated repression during tick transmission. We are now mapping how these and other regulators \u201ctalk\u201d to one another, building an integrated network that drives the transcriptional reprogramming required for infection of both ticks and mammals, and revealing new targets for intervention at the tick\u2013mammal interface.<\/span><\/p>\n<p>&nbsp;<\/p>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Lyme Disease Research Research Lyme Disease Research &#8211; Borrelia burgdorferi Lyme disease is the most common vector-borne infection in the United States, with Connecticut at the epicenter of its public health burden. Our group investigates how B. burgdorferi, the Lyme disease spirochete, adapts as it cycles between ticks and mammals. Using conventional RNA-seq and advanced [&hellip;]<\/p>\n","protected":false},"author":38,"featured_media":0,"parent":27,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-blank.php","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-01 11:46:04","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/spirochete-lab\/wp-json\/wp\/v2\/pages\/12"}],"collection":[{"href":"https:\/\/health.uconn.edu\/spirochete-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/health.uconn.edu\/spirochete-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/spirochete-lab\/wp-json\/wp\/v2\/users\/38"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/spirochete-lab\/wp-json\/wp\/v2\/comments?post=12"}],"version-history":[{"count":16,"href":"https:\/\/health.uconn.edu\/spirochete-lab\/wp-json\/wp\/v2\/pages\/12\/revisions"}],"predecessor-version":[{"id":542,"href":"https:\/\/health.uconn.edu\/spirochete-lab\/wp-json\/wp\/v2\/pages\/12\/revisions\/542"}],"up":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/spirochete-lab\/wp-json\/wp\/v2\/pages\/27"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/spirochete-lab\/wp-json\/wp\/v2\/media?parent=12"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}