The Buck Institute for Research on Aging has received a $3.5 million federal grant to lead the first-ever double-blind, randomized, placebo-controlled clinical trial to understand the effects of ketone ester supplementation on frailty, a condition that develops following age-related decline in multiple physiological systems. TAKEOFF (Targeting Aging with Ketone Ester in Older Adults for Function in Frailty) will recruit a total of 180 people at the Buck, Ohio State University, and the University of Connecticut (UConn).