Pepper Publications

2025

  • Kumar V, Hevener AL, Ruby JG, Sebastiani P, Kuchel GA, Participants of the NIA Heterogeneity and Successful Aging Workshop. Workshop Report-Heterogeneity and Successful Aging Part II: Approaches to Investigate Heterogeneity in Aging Research. J Gerontol A Biol Sci Med Sci, 80, 5, 2025 Apr 7, https://doi.org/10.1093/gerona/glaf021 | 40257451 (PMC12010706)
  • Diniz BS, Chen Z, Steffens DC, Pilling L, Nikolova Y, Clifford K, Fortinsky RH, Kuchel GA, Kuo CL. Proteogenomic signature of Alzheimer's disease and related dementia risk in individuals with major depressive disorder. Nat Ment Health, 3, 8, 2025 Aug, Pages 879-888 https://doi.org/10.1038/s44220-025-00460-0 | 40823340 (PMC12356225)
  • Diniz BS, Zhao S, Drouard G, Vuoksimaa E, Ollikainen M, Lenze EJ, Xu M, Fortinsky RH, Kuchel GA, Kaprio J, Kuo CL. Biological Aging Acceleration in Major Depressive Disorder: A Multi-Omics Analysis. Aging Cell, 2025 Dec 4, Pages e70310 https://doi.org/10.1111/acel.70310 | 41342072
  • Kositsawat J, Zhao S, Kuchel GA, Barry LC, Fortinsky RH, Kirk B, Duque G, Kuo CL. Interactions between vitamin D deficiency and inflammation on diabetes risk: data from 336,500 UK Biobank adults. J Nutr Health Aging, 29, 2, 2025 Feb, Pages 100446 https://doi.org/10.1016/j.jnha.2024.100446 | 39662157 (PMC12179973)
  • Al-Naggar IM, Antony M, Baker D, Wang L, Godoy LDC, Kuo CL, Fraser MO, Smith PP, Xu M, Kuchel GA. Polyploid superficial uroepithelial bladder barrier cells express features of cellular senescence across the lifespan and are insensitive to senolytics. Aging Cell, 24, 2, 2025 Feb, Pages e14399 https://doi.org/10.1111/acel.14399 | 39644167 (PMC11822673)
  • Paek H, Fortinsky RH, Lee K, Huang LC, Maghaydah YS, Kuchel GA, Wang X. Real-World Insights Into Dementia Diagnosis Trajectory and Clinical Practice Patterns Unveiled by Natural Language Processing: Development and Usability Study. JMIR Aging, 8, , 2025 Feb 25, Pages e65221 https://doi.org/10.2196/65221 | 39999185 (PMC11878476)
  • Gasek NS, Yan P, Zhu J, Purushothaman KR, Kim T, Wang L, Wang B, Flynn WF, Sun M, Guo C, Huggins B, Sharafieh R, Zhou Y, Parizek V, Tchkonia T, Kirkland JL, Wyles SP, Xu M. Clearance of p21 highly expressing senescent cells accelerates cutaneous wound healing. Nat Aging, 5, 1, 2025 Jan, Pages 21-27 https://doi.org/10.1038/s43587-024-00755-4 | 39537987 (PMC12205026)
  • Kobayashi M, Leidner AJ, Gierke R, Xing W, Accorsi E, Moro P, Kamboj M, Kuchel GA, Schechter R, Loehr J, Cohen AL. Expanded Recommendations for Use of Pneumococcal Conjugate Vaccines Among Adults Aged =50 Years: Recommendations of the Advisory Committee on Immunization Practices - United States, 2024. MMWR Morb Mortal Wkly Rep, 74, 1, 2025 Jan 9, Pages 1-8 https://doi.org/10.15585/mmwr.mm7401a1 | 39773952 (PMC11709131)
  • Steffens DC, Wang L, Manning KJ, Pearlson GD. Structural Brain Changes Associated With Risky Drinking in Late-Life Depression.
    Am J Geriatr Psychiatry Open Sci Educ Pract, 6, , 2025 Jun, Pages 1-14 https://doi.org/10.1016/j.osep.2025.01.003 | 40535612 (PMC12176382)
  • Woon E, Zhang S, Chen L, Kuchel G, Bartley J, Feng B. Integrated assessment of continuous uroflow cystometry and visceromotor responses to bladder distension in urethane-anesthetized mice. J Pharmacol Exp Ther, 392, 6, 2025 Jun, Pages 103587 https://doi.org/10.1016/j.jpet.2025.103587 | 40378636
  • Drouard G, Palviainen T, Kuo CL, Diniz BS, Wang X, Ollikainen M, Latvala A, Kaprio J. Protein Associations With Alcohol Consumption and Genetic Risk for Alcohol-Related. Sociomedical Conditions. Addict Biol, 30, 6, 2025 Jun, Pages e70045 https://doi.org/10.1111/adb.70045 | 40556615 (PMC12188143)
  • Wyles SP, Yu GT, Ganier C, Tchkonia T, Lynch MD, Kuchel GA, Kirkland JL. SenSkin™: a human skin-specific cellular senescence gene set.
    Geroscience, 47, 3, 2025 Jun, Pages 2631-2638 https://doi.org/10.1007/s11357-025-01568-y | 39998731 (PMC12181445)
  • Fortinsky RH, Al-Naggar IM, Barry LC, Dillon EC, Kuchel GA, Robison J. Expanding Geroscience to Vulnerable Populations in Mid-Late Life: Medicaid Home- and Community-Based Service Users and Formerly Incarcerated Individuals. J Gerontol A Biol Sci Med Sci, 80, 7, 2025 Jun 10, https://doi.org/10.1093/gerona/glaf040 | 40036259 (PMC12363221)
  • Hajj-Boutros G, Faust A, Muscedere J, Kim P, Gouspillou G, Harrington L, Kirkland JL, Kuchel GA, Van Raamsdonk J, Rylett RJ, Autexier C, Lapierre LR, Kobor M, Auais M, Beliën A, Aerssens J, Sutphin G, Rockwood K, Papaioannou A, Sim M, Justice J, Mayo N, Duque G. Foundations and Strategic Vision of the Canadian Translational Geroscience Network. J Gerontol A Biol Sci Med Sci, 80, 7, 2025 Jun 10, https://doi.org/10.1093/gerona/glaf111 | 40383710 (PMC12238536)
  • Kuo CL, Liu P, Drouard G, Vuoksimaa E, Kaprio J, Ollikainen M, Chen Z, Pilling LC, Atkins JL, Fortinsky RH, Kuchel GA, Diniz BS. A proteomic signature of healthspan.
    Proc Natl Acad Sci U S A, 122, 23, 2025 Jun 10, Pages e2414086122 https://doi.org/10.1073/pnas.2414086122 | 40478878 (PMC12168021)
  • Tanguay AP, Menon NG, Slavin E, Moody M, McEwen E, Jay GD, Lorenzo J, Bartley JM, Scanlon VM, Deymier AC, Schmidt TA. Proteoglycan-4 (PRG4) serum concentration is lower in aged mice, and genetic deficiency impacts survival probability, blood parameters, and bone during aging. Geroscience, 2025 Jun 19, https://doi.org/10.1007/s11357-025-01747-x | 40537697
  • Kuchel GA, Hevener AL, Ruby JG, Sebastiani P, Kumar V. Workshop Report-Heterogeneity and Successful Aging Part I: Heterogeneity in Aging-Challenges and Opportunities.
    J Gerontol A Biol Sci Med Sci, 80, 4, 2025 Mar 7, https://doi.org/10.1093/gerona/glaf023 | 40052564 (PMC12314531)
  • Binder EF, Bartley JM, Berry SD, Doré PM, Fisher SR, Fortinsky RH, Guild C, Kiel DP, Kuchel GA, Marcus RL, McDonough CM, Monroe KM, Orwig DL, Paluch RA, Reeds D, Stevens-Lapsley J, Volpi E, Schechtman KB, Magaziner JS. Combining Exercise Training and Testosterone Therapy in Older Women After Hip Fracture: The STEP-HI Randomized Clinical Trial. JAMA Netw Open, 8, 5, 2025 May 1, Pages e2510512 https://doi.org/10.1001/jamanetworkopen.2025.10512 | 40372752 (PMC12082367)
  • Feng B, Kuchel GA. Mechanistic Insights From Reduced Bladder Preparations: A Necessary Complement to In Vivo Models.
    Low Urin Tract Symptoms, 17, 6, 2025 Nov, Pages e70035 https://doi.org/10.1111/luts.70035 | 41177762
  • Darbandsari P, Pescatello LS, Piscitelli D, Smith JM, Ugolini A, Colón-Semenza C. Effect of Telerehabilitation in Parkinson Disease: A Systematic Review and Meta-Analysis.
    Phys Ther, 105, 11, 2025 Nov 3, pii: pzaf121. https://doi.org/10.1093/ptj/pzaf121 | 41065729
  • Nwakasi C, Salafia C, Nweke C, Bellizzi K, Park CL. Perceived control of illness and social support predict subsequent fear of cancer recurrence in adults with cancer.
    J Cancer Surviv, 2025 Oct 2, https://doi.org/10.1007/s11764-025-01901-6 | 41039086
  • Kumar M, Zhao S, Robinson P, Kuchel GA, Fortinsky RH, Orkaby AR, Alexander KP, Thompson PD, Batsis JA, Kuo CL. Advancing Age and Risk From the Elevated Atherogenic Index: Triglyceride (TG) to High-Density Cholesterol (HDL-C) Ratio. J Am Geriatr Soc, 73, 9, 2025 Sep, Pages 2738-2746 https://doi.org/10.1111/jgs.19607 | 40581837
  • Woon E, Santeli JV, Liu J, Chen L, Kuchel G, Feng B. Pharmacological Targeting of Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channels on Bladder Afferent Sensory Transmission. Low Urin Tract Symptoms, 17, 5, 2025 Sep, Pages e70025 https://doi.org/10.1111/luts.70025 | 40761184 (PMC12322805)
  • Chia SB, Johnson BJ, Hu J, Valença-Pereira F, Chadeau-Hyam M, Guntoro F, Montgomery H, Boorgula MP, Sreekanth V, Goodspeed A, Davenport B, De Dominici M, Zaberezhnyy V, Schleicher WE, Gao D, Cadar AN, Petriz-Otaño L, Papanicolaou M, Beheshti A, Baylin SB, Guarnieri JW, Wallace DC, Costello JC, Bartley JM, Morrison TE, Vermeulen R, Aguirre-Ghiso JA, Rincon M, DeGregori J. Respiratory viral infections awaken metastatic breast cancer cells in lungs.
    Nature, 645, 8080, 2025 Sep, Pages 496-506 https://doi.org/10.1038/s41586-025-09332-0 | 40739350 (PMC12422975)
  • Fortinsky RH, Robison J, Grady J, Migneault D, Steffens DC, Lee CM, Wakefield D J Appl Gerontol, 2025 Sep 9, Pages 7334648251377491. Emergency Department Visits and Hospital Admissions Among Older Adults With and Without Dementia Receiving Medicaid-Funded Home- and Community-Based Services. https://doi.org/10.1177/07334648251377491 | 40925339 (PMC12643127)

2024

  • Gasek NS, Yan P, Zhu J, Purushothaman K-R, Kim T, Wang L, Wang B, Flynn WF, Sun M, Guo C, Higgins B, Sharafieh R, Zhou Y, Parizek V, Tchkonia T, Kirkland JL, Wyles SP, Xu M. Clearance of p21 highly expressing senescent cells accelerates cutaneous wound healing. Nature Aging. 2024 Nov 13; ahead of print: https://doi.org/10.1038/s43587-024-00755-4
  • Sharafieh R*, Qiao Y, Godlewski I, Czajkowski C, Wu R, Hargis GR, Kreutzer D, Klueh U. Impact of Bindarit, a CCL2 chemokine synthesis inhibitor, on macrophage-based biofouling and continuous glucose monitoring in vivo. Biosensors and Bioelectronics: X. 2024 Aug ahead of print; (19):100511. https://doi.org/10.1016/j.biosx.2024.100511
  • Lindbergh, C. A., Altizer Jr., R., Grady, J. J., Diniz, B. S., Kamath, J., Steffens, D. C., & Morimoto, S. S. (2024). Computerized cognitive remediation of Long COVID in older adults. International Psychogeriatrics, 1-3.
  • Cristina Colón-Semenza, et al. Comparing Physical Activity and Exercise Experiences, Values, and Beliefs of Latino, Latina, and/or Latine People and Non-Latino, Non-Latina, and/or Non-Latine People With Parkinson Disease: A Qualitative Study, Physical Therapy, Volume 104, Issue 10, October 2024, pzae119, https://doi.org/10.1093/ptj/pzae119
  • J. Fanning, T.E. Brinkley, L.M. Campbell, C. Colón-Semenza, S.J. Czaja, R.C. Moore, N.M. Pajewski, S. Kritchevsky. Research Centers Collaborative Network Workshop on Digital Health Approaches to Research in Aging. Innov Aging. 2024 Feb 8;8(2):igae012. doi: 10.1093/geroni/igae012. PMID: 38464460; PMCID: PMC10924449.
  • Steffens, DC, Manning, KJ, Wu R, Ford JD.  Adverse Childhood Experiences and Cognitive Change in Late-Life Depression. American Journal of Geriatric Psychiatry: Open Science, Education, and Practice 2024; 4:1−6

2023

  • Fortinsky RH, Shugrue N, Robison JT, Gitlin LN. The Case for Conducting Pragmatic Dementia Care Trials in Medicaid Home and Community-Based Service Settings. J Am Med Dir Assoc. 2023 Dec;24(12):1918-1923. doi: 10.1016/j.jamda.2023.09.026.
  • Monica M. Nader, Caglar Cosarderelioglu, Emily Miao, Heather Whitson, Qian-Li Xue, Francine Grodstein, Esther Oh, Luigi Ferrucci, David A. Bennett, Jeremy D. Walston, Claudene George, Peter M. Abadir. Navigating and diagnosing cognitive frailty in research and clinical domains. Nat Aging (2023). https://doi.org/10.1038/s43587-023-00504-z
  • Martin DE, Cadar AN, Panier H, Torrance BL, Kuchel GA, Bartley JM. “The Effect of Metformin on Influenza Vaccine Responses in Nondiabetic Older Adults: A Pilot Trial”. Immunity and Ageing. Accepted April 2023.
  • Kathleen K. Mangione, Hope Darreff, McKenna Welsh, Weihong Ni, Edward Wolff, Julie T. Booth, Susan S. Glenney, and Richard H. Fortinsky. Feasibility of a Modified Otago Exercise Program for Older Adults With Cognitive Vulnerability. Journal of Applied Gerontology. 2023, Vol. 0(0) 1–11. PMID: 36919309. DOI: 10.1177/07334648231163050.
  • Kathy Kellett, PhD, Julie Robison, PhD, Heather McAbee-Sevick, MS, Laura N. Gitlin, PhD, FGSA, FAAN, Catherine Verrier Piersol, PhD, OTR/L, FAOTA, and Richard H. Fortinsky, PhD. Implementing the Care of PersonsWith Dementia in Their Environments (COPE) Intervention in Community-Based Programs: Acceptability and Perceived Benefit From Care Managers’ and Interventionists’ Perspectives. The Gerontologist,. 63, 28–39 (2023). doi.org/10.1093/geront/gnac068.

2022

  • Fortinsky RH, Robison J, Steffens DC, Grady J, Migneault D, Wakefield D. Association of Race, Ethnicity, Education, and Neighborhood Context with Dementia Prevalence and Cognitive Impairment Severity among Older Adults receiving Medicaid-funded Home and Community-based Services. American Journal of Geriatric Psychiatry. Doi:10.1016/j.jagp.2022.12.001.
  • Adams KB, Parekh R, Mauldin RL, Fortinsky RH, Steffens DC. The risk for loneliness and major depression among solo agers. Journal of Applied Gerontology. 2022, in press.
  • Steffens, D.C., Fahed, M., Manning, K.J. et al. The neurobiology of apathy in depression and neurocognitive impairment in older adults: a review of epidemiological, clinical, neuropsychological and biological research. Transl Psychiatry 12, 525 (2022). https://doi.org/10.1038/s41398-022-02292-3
  • Larson PJ, Zhou W, Santiago A, Driscoll S, Fleming E, Voigt AY, Chun OK, Grady JJ, Kuchel GA, Robison JT, Oh J. Associations of the skin, oral and gut microbiome with aging, frailty and infection risk reservoirs in older adults. Nat Aging. 2022 Oct;2(10):941-955. doi: 10.1038/s43587-022-00287-9. Epub 2022 Oct 12. PMID: 36398033; PMCID: PMC9667708.
  • Torrance BL, Haynes L. Cellular senescence is a key mediator of lung aging and susceptibility to infection. Front Immunol. 2022 Aug 31;13:1006710. doi: 10.3389/fimmu.2022.1006710. PMID: 36119079; PMCID: PMC9473698.
  • Lorenzo EC, Torrance BL, Keilich SR, Al-Naggar I, Harrison A, Xu M, Bartley JM, Haynes L. Senescence-induced changes in CD4 T cell differentiation can be alleviated by treatment with senolytics. Aging Cell. 2022 Jan;21(1):e13525. doi: 10.1111/acel.13525. Epub 2021 Dec 27. PMID: 34962049; PMCID: PMC8761018.
    • Andrade AM, Sun M, Gasek NS, Hargis GR, Sharafieh R, Xu M. Role of Senescent Cells in Cutaneous Wound Healing. Biology. 2022; 11(12):1731. https://doi.org/10.3390/biology11121731
    • Lorenzo EC, Kuchel GA, Kuo CL, Moffitt TE, Diniz BS. Major depression and the biological hallmarks of aging. Ageing Res Rev. 2022 Nov 18:101805. doi: 10.1016/j.arr.2022.101805. Epub ahead of print. PMID: 36410621.
    • Diniz, B. S., Lima-Costa, M. F., Peixoto, S. V., Firmo, J., Torres, K., Martins-Filho, O. A., Teixeira-Carvalho, A., Grady, J., Kuchel, G. A., & Castro-Costa, E. (2022). Cognitive Frailty is Associated With Elevated Proinflammatory Markers and a Higher Risk of Mortality. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 30(7), 825–833. https://doi.org/10.1016/j.jagp.2022.01.012
    • Kuffel, R. L., Byers, A. L., Williams, B., Fortinsky, R., Li, Y., Ruderman, M. A., & Barry, L. C. (2022). Prevalence of dementia and mild cognitive impairment before incarceration. Journal of the American Geriatrics Society, 70(6), 1792–1799. https://doi.org/10.1111/jgs.17724
    • Kulkarni AS, Aleksic S, Berger DM, Sierra F, Kuchel GA, Barzilai N. Geroscience-guided repurposing of FDA-approved drugs to target aging: A proposed process and prioritization. Aging Cell. 2022 Apr;21(4):e13596. doi: 10.1111/acel.13596. Epub 2022 Mar 27. PMID: 35343051; PMCID: PMC9009114.
    • Lorenzo, E. C., Torrance, B. L., Keilich, S. R., Al-Naggar, I., Harrison, A., Xu, M., Bartley, J. M., & Haynes, L. (2022). Senescence-induced changes in CD4 T cell differentiation can be alleviated by treatment with senolytics. Aging cell, 21(1), e13525. https://doi.org/10.1111/acel.13525
    • Masters MC, Landay AL, Robbins PD, Tchkonia T, Kirkland JL, Kuchel GA, Niedernhofer LJ, Palella FJ. Chronic HIV Infection and Aging: Application of a Geroscience-Guided Approach. J Acquir Immune Defic Syndr. 2022 Feb 1;89(Suppl 1):S34-S46. doi: 10.1097/QAI.0000000000002858.
    • Picard, E., Armstrong, S., Andrew, M. K., Haynes, L., Loeb, M., Pawelec, G., Kuchel, G. A., McElhaney, J. E., & Verschoor, C. P. (2022). Markers of systemic inflammation are positively associated with influenza vaccine antibody responses with a possible role for ILT2(+)CD57(+) NK-cells. Immunity & ageing : I & A, 19(1), 26. https://doi.org/10.1186/s12979-022-00284-x
    • Soliman G, Fortinsky RH, Mangione KK, Beamer BA, Magder L, Binder EF, Craik R, Gruber-Baldini A, Orwig D, Resnick B, Wakefield DB, Magaziner J. Impact of psychological resilience on walking capacity in older adults following hip fracture. Journal of the American Geriatrics Society 2022. https://doi:10.1111/jgs.17930
    • Wang, L., Wang, B., Gasek, N. S., Zhou, Y., Cohn, R. L., Martin, D. E., Zuo, W., Flynn, W. F., Guo, C., Jellison, E. R., Kim, T., Prata, L., Palmer, A. K., Li, M., Inman, C. L., Barber, L. S., Al-Naggar, I., Zhou, Y., Du, W., Kshitiz, … Xu, M. (2022). Targeting p21Cip1highly expressing cells in adipose tissue alleviates insulin resistance in obesity. Cell metabolism, 34(1), 75–89.e8. https://doi.org/10.1016/j.cmet.2021.11.002

    2021

    • DePalma, A., Noujaim, D., Coman, E., Wakefield, D., & Barry, L. C. (2021). Older incarcerated persons' mental health before and during the COVID-19 pandemic. International journal of prisoner health, ahead-of-print(ahead-of-print), 10.1108/IJPH-08-2021-0077. https://pubmed.ncbi.nlm.nih.gov/34854275/
    • Kannan K, Rogina B. The Role of Citrate Transporter INDY in Metabolism and Stem Cell Homeostasis. Metabolites. 2021 Oct 15;11(10):705. doi: 10.3390/metabo11100705. PMID: 34677421; PMCID: PMC8540898.
    • Sedrak, M. S., Kirkland, J. L., Tchkonia, T., & Kuchel, G. A. (2021). Accelerated aging in older cancer survivors. Journal of the American Geriatrics Society, 69(11), 3077–3080. https://doi.org/10.1111/jgs.17461
    • Verschoor, C. P., Pawelec, G., Haynes, L., Loeb, M., Andrew, M. K., Kuchel, G. A., & McElhaney, J. E. (2021). Granzyme B: a double-edged sword in the response to influenza infection in vaccinated older adults. Frontiers in aging, 2, 753767. https://doi.org/10.3389/fragi.2021.753767