{"id":18,"date":"2019-09-10T15:40:01","date_gmt":"2019-09-10T19:40:01","guid":{"rendered":"https:\/\/health.uconn.edu\/bae-lab\/?page_id=18"},"modified":"2026-05-06T09:45:54","modified_gmt":"2026-05-06T13:45:54","slug":"publications","status":"publish","type":"page","link":"https:\/\/health.uconn.edu\/oguro-lab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Cyp7b1-inhibiting azoles enhance hematopoietic stem and progenitor cell mobilization in normal and sickle cell disease mice<\/a><\/strong>
\nBrandon L Vu, Travis J Roeder, Jitendra K Kanaujiya, Amy L Kimble, Eddy Tsang, Hideyuki Oguro
\nHaematologica.<\/strong> 2026 Apr 9<\/p>\n

A reference human induced pluripotent stem cell line for large-scale collaborative studies<\/a><\/strong>
\nCaroline B Pantazis, Andrian Yang, Erika Lara, Justin A McDonough, Cornelis Blauwendraat, Lirong Peng, Hideyuki Oguro, Jitendra Kanaujiya, Jizhong Zou, David Sebesta, Gretchen Pratt, Erin Cross, Jeffrey Blockwick, Philip Buxton, Lauren Kinner-Bibeau, Constance Medura, Christopher Tompkins, Stephen Hughes, Marianita Santiana, Faraz Faghri, Mike A Nalls, Daniel Vitale, Shannon Ballard, Yue A Qi, Daniel M Ramos, Kailyn M Anderson, Julia Stadler, Priyanka Narayan, Jason Papademetriou, Luke Reilly, Matthew P Nelson, Sanya Aggarwal, Leah U Rosen, Peter Kirwan, Venkat Pisupati, Steven L Coon, Sonja W Scholz, Theresa Priebe, Miriam \u00d6ttl, Jian Dong, Marieke Meijer, Lara JM Janssen, Vanessa S Lourenco, Rik van der Kant, Dennis Crusius, Dominik Paquet, Ana-Caroline Raulin, Guojun Bu, Aaron Held, Brian J Wainger, Rebecca MC Gabriele, Jackie M Casey, Selina Wray, Dad Abu-Bonsrah, Clare L Parish, Melinda S Beccari, Don W Cleveland, Emmy Li, Indigo VL Rose, Martin Kampmann, Carles Calatayud Aristoy, Patrik Verstreken, Laurin Heinrich, Max Y Chen, Birgitt Sch\u00fcle, Dan Dou, Erika LF Holzbaur, Maria Clara Zanellati, Richa Basundra, Mohanish Deshmukh, Sarah Cohen, Richa Khanna, Malavika Raman, Zachary S Nevin, Madeline Matia, Jonas Van Lent, Vincent Timmerman, Bruce R Conklin, Katherine Johnson Chase, Ke Zhang, Salome Funes, Daryl A. Bosco, Lena Erlebach, Marc Welzer, Deborah Kronenberg-Versteeg, Guochang Lyu, Ernest Arenas, Elena Coccia, Lily Sarrafha, Tim Ahfeldt, John C Marioni, William C Skarnes, Mark R Cookson, Michael E Ward, Florian T Merkle
\nCell Stem Cell.<\/strong> 2022;29(12):1685\u20131702<\/p>\n

Generation of hematopoietic stem and progenitor cells from human pluripotent stem cells<\/a><\/strong>
\nHideyuki Oguro
\nMethods Mol Biol.<\/strong> 2019;2048:245-257<\/p>\n

The roles of cholesterol and its metabolites in normal and malignant hematopoiesis<\/a><\/strong>
\nHideyuki Oguro
\nFront Endocrinol.<\/strong> 2019;10:204<\/p>\n

27-hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy<\/a><\/strong>
\nHideyuki Oguro*, Jeffrey G McDonald, Zhiyu Zhao, Michihisa Umetani, Philip W Shaul, Sean J Morrison* (*co-corresponding author)
\nJ Clin Invest.<\/strong> 2017;127(9):3392-3401<\/p>\n

Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal<\/a><\/strong>
\nMelih Acar, Kiranmai S Kocherlakota, Malea M Murphy, James G Peyer, Hideyuki Oguro, Christopher N Inra, Christabel Jaiyeola, Zhiyu Zhao, Katherine Luby-Phelps, Sean J Morrison
\nNature.<\/strong> 2015;526(7571):126-130<\/p>\n

Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy<\/a><\/strong>
\nDaisuke Nakada, Hideyuki Oguro, Boaz P Levi, Nicole Ryan, Ayumi Kitano, Yusuke Saitoh, Makiko Takeichi, George R Wendt, Sean J Morrison
\nNature.<\/strong> 2014;505(7484):555-558<\/p>\n

Lung bone marrow-derived hematopoietic progenitor cells enhance pulmonary fibrosis<\/a><\/strong>
\nTaku Nakashima, Tianju Liu, Hongfeng Yu, Lin Ding, Matthew Ullenbruch, Biao Hu, Zhe Wu, Hideyuki Oguro, Sem H Phan
\nAm J Respir Crit Care Med.<\/strong> 2013;188(8):976-984<\/p>\n

SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors<\/a><\/strong>
\nHideyuki Oguro, Lei Ding, Sean J Morrison
\nCell Stem Cell.<\/strong> 2013;13(1):102-116<\/p>\n

Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes<\/a><\/strong>
\nHideyuki Oguro, Jin Yuan, Satomi Tanaka, Satoru Miyagi, Makiko Mochizuki-Kashio, Hitoshi Ichikawa, Satoshi Yamazaki, Haruhiko Koseki, Hiromitsu Nakauchi, Atsushi Iwama
\nJ Exp Med.<\/strong> 2012;209(3):445-454<\/p>\n

Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells<\/a><\/strong>
\nTakaaki Konuma, Shunsuke Nakamura, Satoru Miyagi, Masamitsu Negishi, Tetsuhiro Chiba, Hideyuki Oguro, Jin Yuan, Makiko Mochizuki-Kashio, Hitoshi Ichikawa, Hiroyuki Miyoshi, Miguel Vidal, Atsushi Iwama
\nExp Hematol.<\/strong> 2011;39(6):697-709.e5<\/p>\n

Bmi1 is essential for leukemic reprogramming of myeloid progenitor cells<\/a><\/strong>
\nJin Yuan, Masahiro Takeuchi, Masamitsu Negishi, Hideyuki Oguro, Hitoshi Ichikawa, Atsushi Iwama
\nLeukemia.<\/strong> 2011;25(8):1335-1343<\/p>\n

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a\/Arf-dependent and -independent manners in mice<\/a><\/strong>
\nTetsuhiro Chiba, Atsuyoshi Seki, Ryutaro Aoki, Hitoshi Ichikawa, Masamitsu Negishi, Satoru Miyagi, Hideyuki Oguro, Atsunori Saraya, Akihide Kamiya, Hiromitsu Nakauchi, Osamu Yokosuka, Atsushi Iwama
\nHepatology.<\/strong> 2010;52(3):1111-1123<\/p>\n

Role of the polycomb group proteins in hematopoietic stem cells<\/a><\/strong>
\nTakaaki Konuma, Hideyuki Oguro, Atsushi Iwama
\nDev Growth Differ.<\/strong> 2010;52(6):505-516<\/p>\n

FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cells<\/a><\/strong>
\nTakeaki Sugawara, Hideyuki Oguro, Masamitsu Negishi, Yohei Morita, Hitoshi Ichikawa, Toru Iseki, Osamu Yokosuka, Hiromitsu Nakauchi, Atsushi Iwama
\nExp Hematol.<\/strong> 2010;38(8):696-706<\/p>\n

Depletion of Dnmt1-associated protein 1 triggers DNA damage and compromises the proliferative capacity of hematopoietic stem cells<\/a><\/strong>
\nTomoe Koizumi, Masamitsu Negishi, Shunsuke Nakamura, Hideyuki Oguro, Kaneshige Satoh, Masaharu Ichinose, Atsushi Iwama
\nInt J Hematol.<\/strong> 2010;91(4):611-619<\/p>\n

Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1<\/a><\/strong>
\nHideyuki Oguro, Jin Yuan, Hitoshi Ichikawa, Tomokatsu Ikawa, Satoshi Yamazaki, Hiroshi Kawamoto, Hiromitsu Nakauchi, Atsushi Iwama
\nCell Stem Cell.<\/strong> 2010;6(3):279-286<\/p>\n

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL<\/a><\/strong>
\nSahoko Matsuoka, Yuichi Oike, Ichiro Onoyama, Atsushi Iwama, Fumio Arai, Keiyo Takubo, Yoichi Mashimo, Hideyuki Oguro, Eriko Nitta, Keisuke Ito, Kana Miyamoto, Hiroki Yoshiwara, Kentaro Hosokawa, Yuka Nakamura, Yumiko Gomei, Hiroko Iwasaki, Yasuhide Hayashi, Yumi Matsuzaki, Keiko Nakayama, Yasuo Ikeda, Akira Hata, Shigeru Chiba, Keiichi I Nakayama, Toshio Suda
\nGenes Dev.<\/strong> 2008;22(8):986-991<\/p>\n

Life and death in hematopoietic stem cells<\/a><\/strong>
\nHideyuki Oguro, Atsushi Iwama
\nCurr Opin Immunol.<\/strong> 2007;19(5):503-509<\/p>\n

Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo<\/a><\/strong>
\nToshinao Oyama, Kenichi Harigaya, Ablimit Muradil, Katsuto Hozumi, Sonoko Habu, Hideyuki Oguro, Atsushi Iwama, Kenji Matsuno, Reiko Sakamoto, Mitsuharu Sato, Nobuaki Yoshida, Motoo Kitagawa
\nProc Natl Acad Sci U S A.<\/strong> 2007;104(23):9764-9769<\/p>\n

Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice<\/a><\/strong>
\nHideyuki Oguro, Atsushi Iwama, Yohei Morita, Takehiko Kamijo, Maarten van Lohuizen, Hiromitsu Nakauchi
\nJ Exp Med.<\/strong> 2006 Oct 2;203(10):2247-2253<\/p>\n

A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells<\/a><\/strong>
\nMasanori Sakaguchi, Tetsuro Shingo, Takuya Shimazaki, Hirotaka James Okano, Mieko Shiwa, Satoru Ishibashi, Hideyuki Oguro, Mikiko Ninomiya, Toshihiko Kadoya, Hidenori Horie, Akira Shibuya, Hidehiro Mizusawa, Fran\u00e7oise Poirier, Hiromitsu Nakauchi, Kazunobu Sawamoto, Hideyuki Okano
\nProc Natl Acad Sci U S A.<\/strong> 2006;103(18):7112-7117<\/p>\n

The Sox2 regulatory region 2 functions as a neural stem cell-specific enhancer in the telencephalon<\/a><\/strong>
\nSatoru Miyagi, Masazumi Nishimoto, Tetsuichiro Saito, Mikiko Ninomiya, Kazunobu Sawamoto, Hideyuki Okano, Masami Muramatsu, Hideyuki Oguro, Atsushi Iwama, Akihiko Okuda
\nJ Biol Chem.<\/strong> 2006;281(19):13374-13381<\/p>\n

Polycomb gene product Bmi-1 regulates stem cell self-renewal<\/a><\/strong>
\nHiromitsu Nakauchi, Hideyuki Oguro, Masamitsu Negishi, Atsushi Iwama
\nErnst Schering Res Found Workshop.<\/strong> 2005;(54):85-100<\/p>\n

Epigenetic regulation of hematopoietic stem cell self-renewal by polycomb group genes<\/a><\/strong>
\nAtsushi Iwama, Hideyuki Oguro, Masamitsu Negishi, Yuko Kato, Hiromitsu Nakauchi
\nInt J Hematol.<\/strong> 2005;81(4):294-300<\/p>\n

Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1<\/a><\/strong>
\nAtsushi Iwama*, Hideyuki Oguro*, Masamitsu Negishi, Yuko Kato, Youhei Morita, Hiroko Tsukui, Hideo Ema, Takehiko Kamijo, Yuko Katoh-Fukui, Haruhiko Koseki, Maarten van Lohuizen, Hiromitsu Nakauchi (*co-first author)
\nImmunity.<\/strong> 2004;21(6):843-851<\/p>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

Cyp7b1-inhibiting azoles enhance hematopoietic stem and progenitor cell mobilization in normal and sickle cell disease mice Brandon L Vu, Travis J Roeder, Jitendra K Kanaujiya, Amy L Kimble, Eddy Tsang, Hideyuki Oguro Haematologica. 2026 Apr 9 A reference human induced pluripotent stem cell line for large-scale collaborative studies Caroline B Pantazis, Andrian Yang, Erika Lara, […]<\/p>\n","protected":false},"author":38,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-21 15:45:03","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/oguro-lab\/wp-json\/wp\/v2\/pages\/18"}],"collection":[{"href":"https:\/\/health.uconn.edu\/oguro-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/health.uconn.edu\/oguro-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/oguro-lab\/wp-json\/wp\/v2\/users\/38"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/oguro-lab\/wp-json\/wp\/v2\/comments?post=18"}],"version-history":[{"count":21,"href":"https:\/\/health.uconn.edu\/oguro-lab\/wp-json\/wp\/v2\/pages\/18\/revisions"}],"predecessor-version":[{"id":242,"href":"https:\/\/health.uconn.edu\/oguro-lab\/wp-json\/wp\/v2\/pages\/18\/revisions\/242"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/oguro-lab\/wp-json\/wp\/v2\/media?parent=18"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}