{"id":8014,"date":"2026-09-14T14:26:38","date_gmt":"2026-09-14T18:26:38","guid":{"rendered":"https:\/\/health.uconn.edu\/neuroscience\/?p=8014"},"modified":"2026-09-14T14:45:27","modified_gmt":"2026-09-14T18:45:27","slug":"trakhtenberg-lab-uncovers-new-regulators-of-neuronal-self-repair","status":"publish","type":"post","link":"https:\/\/health.uconn.edu\/neuroscience\/2026\/09\/14\/trakhtenberg-lab-uncovers-new-regulators-of-neuronal-self-repair\/","title":{"rendered":"Trakhtenberg Lab Uncovers New Regulators of Neuronal Self-Repair"},"content":{"rendered":"<p>Recent advances from the Trakhtenberg lab have uncovered promising targetable regulators of neuronal self-repair, which fail to self-activate sufficiently in the injured mammalian CNS and thus require therapeutic activation. To find out more, see the below links to a Cover Page research article in <em>Experimental Neurology<\/em>, a research report in <em>Brain Research<\/em>, and research reports in Cell Press\u2019s journals, <em>Molecular Therapy Advances<\/em> and <em>Molecular Therapy Nucleic Acids<\/em>.<\/p>\n<p>&nbsp;<\/p>\n<p>\u201c<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42002019\/\">Experimental upregulation of Lancl1 promotes axon regeneration after optic nerve injury in vivo<\/a>\u201d (PMID 42002019)<\/p>\n<p>&nbsp;<\/p>\n<p>\u201c<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42386070\/\">Targeting neurodevelopmental miR132-3p promotes neuroprotection and axon regeneration after optic nerve injury in mice<\/a>\u201d (PMID 42386070)<\/p>\n<p>&nbsp;<\/p>\n<p>\u201c<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42656966\/\">Neurodevelopmental miR-135a-1-3p and miR-135b-3p promote long-distance axon regeneration after injury in the central visual pathway<\/a>\u201d (PMID 42656966)<\/p>\n<p>&nbsp;<\/p>\n<p>\u201c<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42023031\/\">Vacuolar ATPase subunit Atp6v0c transgene promotes neuroprotection and long-distance axon regeneration in injured retinal ganglion neurons<\/a>\u201d (PMID 42023031)<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/health.uconn.edu\/neuroscience\/wp-content\/uploads\/sites\/121\/2026\/09\/Cover-page.jpg\"><img loading=\"lazy\" decoding=\"async\" data-src=\"https:\/\/health.uconn.edu\/neuroscience\/wp-content\/uploads\/sites\/121\/2026\/09\/Cover-page-225x300.jpg\" alt=\"Experimental Neurology \" width=\"280\" height=\"373\" class=\"wp-image-8015 aligncenter lazyload\" data-srcset=\"https:\/\/health.uconn.edu\/neuroscience\/wp-content\/uploads\/sites\/121\/2026\/09\/Cover-page-225x300.jpg 225w, https:\/\/health.uconn.edu\/neuroscience\/wp-content\/uploads\/sites\/121\/2026\/09\/Cover-page.jpg 576w\" data-sizes=\"(max-width: 280px) 100vw, 280px\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 280px; --smush-placeholder-aspect-ratio: 280\/373;\" \/><noscript><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/health.uconn.edu\/neuroscience\/wp-content\/uploads\/sites\/121\/2026\/09\/Cover-page-225x300.jpg\" alt=\"Experimental Neurology \" width=\"280\" height=\"373\" class=\"wp-image-8015 aligncenter\" srcset=\"https:\/\/health.uconn.edu\/neuroscience\/wp-content\/uploads\/sites\/121\/2026\/09\/Cover-page-225x300.jpg 225w, https:\/\/health.uconn.edu\/neuroscience\/wp-content\/uploads\/sites\/121\/2026\/09\/Cover-page.jpg 576w\" sizes=\"(max-width: 280px) 100vw, 280px\" \/><\/noscript><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Recent advances from the Trakhtenberg lab have uncovered promising targetable regulators of neuronal self-repair, which fail to self-activate sufficiently in the injured mammalian CNS and thus require therapeutic activation. To find out more, see the below links to a Cover Page research article in Experimental Neurology, a research report in Brain Research, and research reports [&hellip;]<\/p>\n","protected":false},"author":2772,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"wds_primary_category":0,"footnotes":""},"categories":[4,5],"tags":[],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-09-22 00:10:50","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/posts\/8014"}],"collection":[{"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/users\/2772"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/comments?post=8014"}],"version-history":[{"count":3,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/posts\/8014\/revisions"}],"predecessor-version":[{"id":8020,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/posts\/8014\/revisions\/8020"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/media?parent=8014"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/categories?post=8014"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/tags?post=8014"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}