{"id":7369,"date":"2024-11-04T16:27:04","date_gmt":"2024-11-04T21:27:04","guid":{"rendered":"https:\/\/health.uconn.edu\/neuroscience\/?p=7369"},"modified":"2024-11-04T16:27:17","modified_gmt":"2024-11-04T21:27:17","slug":"next-generation-mirna-inhibitors-for-the-treatment-of-stroke","status":"publish","type":"post","link":"https:\/\/health.uconn.edu\/neuroscience\/2024\/11\/04\/next-generation-mirna-inhibitors-for-the-treatment-of-stroke\/","title":{"rendered":"Next generation miRNA inhibitors for the treatment of stroke"},"content":{"rendered":"<p>Verma lab in collaboration of Bahal lab from Storrs campus has published their new finding about leveraging the \u00a0benefits of advanced gamma Peptic Nucleic Acid based miRNA-141 inhibitor for the treatment of ischemic stroke. Their finding was published in the journal <u><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2162253124002427?via%3Dihub\">Molecular Therapy: Nucleic Acid.<\/a><\/u> \u00a0In this work first author Dr Sanjeev Kumar Yadav found that gamma PNA based substitution not only improves efficacy for miR-141 inhibition, but this inhibitor is highly potent and provides long term recovery in mouse model of ischemic stroke. This inhibitor also reduces inflammation of the brain after stroke . Their work also found place in UConn today news <u><a href=\"https:\/\/today.uconn.edu\/2024\/10\/uconn-researchers-working-to-extinguish-inflammatory-fire-stroke-causes-in-the-brain\/\">https:\/\/today.uconn.edu\/2024\/10\/uconn-researchers-working-to-extinguish-inflammatory-fire-stroke-causes-in-the-brain\/<\/a><\/u><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Verma lab in collaboration of Bahal lab from Storrs campus has published their new finding about leveraging the \u00a0benefits of advanced gamma Peptic Nucleic Acid based miRNA-141 inhibitor for the treatment of ischemic stroke. Their finding was published in the journal Molecular Therapy: Nucleic Acid. \u00a0In this work first author Dr Sanjeev Kumar Yadav found [&hellip;]<\/p>\n","protected":false},"author":2772,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"wds_primary_category":0,"footnotes":""},"categories":[1],"tags":[],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-22 01:01:34","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/posts\/7369"}],"collection":[{"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/users\/2772"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/comments?post=7369"}],"version-history":[{"count":1,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/posts\/7369\/revisions"}],"predecessor-version":[{"id":7370,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/posts\/7369\/revisions\/7370"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/media?parent=7369"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/categories?post=7369"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/tags?post=7369"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}