{"id":5279,"date":"2022-03-02T12:37:32","date_gmt":"2022-03-02T17:37:32","guid":{"rendered":"https:\/\/health.uconn.edu\/neuroscience\/?p=5279"},"modified":"2022-03-08T11:33:36","modified_gmt":"2022-03-08T16:33:36","slug":"a-defense-bunker-for-retinal-citrullination-mohan","status":"publish","type":"post","link":"https:\/\/health.uconn.edu\/neuroscience\/2022\/03\/02\/a-defense-bunker-for-retinal-citrullination-mohan\/","title":{"rendered":"A defense bunker for retinal citrullination – Mohan"},"content":{"rendered":"

A defense bunker for retinal citrullination <\/strong><\/p>\n

To avert combating stress at the epicenter of phototransduction, the process by which light is converted to a neural signal in photoreceptors, neuroscience professor Royce Mohan at the UConn School of Medicine proposes that the mammalian retina may have evolved a novel defense strategy to respond to injury and disease. Studying retinal pathology, his lab has unraveled that citrullination, a type of protein modification, is triggered in a specialized zone of Muller glia known as the endfeet. The segregation of citrullination and phototransduction may help to limit vision loss during retinal stress, but chronic hypercitrullination seen in age-related macular degeneration may lead to fibrosis and blindness. Mohan has coined the term citrullination bunker<\/em> to illustrate this previously unknown compartmentalized citrullination armory within the retina.\u00a0 To read the press release published in UConn Today, please click here.<\/a>\u00a0The study by graduate student Sarah Palko (featured here) and coworkers appears in the March 1, 2022 issue of the Proceedings of the National Academy of Sciences<\/em>.<\/p>\n

To read more about this published study, please click here.<\/a><\/p>\n

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\"Mohan