{"id":4995,"date":"2021-09-16T16:24:03","date_gmt":"2021-09-16T20:24:03","guid":{"rendered":"https:\/\/health.uconn.edu\/neuroscience\/?p=4995"},"modified":"2021-09-16T16:25:43","modified_gmt":"2021-09-16T20:25:43","slug":"traffic-jams-in-parkinsons-disease-xiong","status":"publish","type":"post","link":"https:\/\/health.uconn.edu\/neuroscience\/2021\/09\/16\/traffic-jams-in-parkinsons-disease-xiong\/","title":{"rendered":"Traffic Jams in Parkinson&#8217;s Disease &#8211; Yulan Xiong"},"content":{"rendered":"<p>As posted in UConn <strong>Today<\/strong><strong><\/strong><br \/>\n<em>September 15, 2021 | Kim Krieger UConn Communications<\/em><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/health.uconn.edu\/neuroscience\/wp-content\/uploads\/sites\/121\/2021\/09\/Xiong-lab-traffic-jams.png\"><img loading=\"lazy\" decoding=\"async\" data-src=\"https:\/\/health.uconn.edu\/neuroscience\/wp-content\/uploads\/sites\/121\/2021\/09\/Xiong-lab-traffic-jams.png\" alt=\"Xiong Lab\" class=\"size-full wp-image-4996 alignleft lazyload\" width=\"252\" height=\"300\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 252px; --smush-placeholder-aspect-ratio: 252\/300;\" \/><noscript><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/health.uconn.edu\/neuroscience\/wp-content\/uploads\/sites\/121\/2021\/09\/Xiong-lab-traffic-jams.png\" alt=\"Xiong Lab\" class=\"size-full wp-image-4996 alignleft\" width=\"252\" height=\"300\" \/><\/noscript><\/a><strong><\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><strong>M<\/strong>utations in a protein known to cause Parkinson\u2019s Disease derange transportation in and out of brain cells, reports a team of UConn Health researchers in<span>\u00a0<\/span><a href=\"https:\/\/www.science.org\/doi\/10.1126\/scisignal.abg3555\">the 27 July issue of Science Signaling<\/a>. The toxic traffic jams that result eventually lead to certain brain cell death and the characteristic symptoms of Parkinson\u2019s.<\/p>\n<p>\u201cWe figured out how LRRK2 causes dopaminergic neurodegeneration,\u201d the break down and death of brain cells that control the movement of our body, says Yulan Xiong, a neuroscientist in UConn Health\u2019s School of Medicine. LRRK2 is a gene that codes for a protein in our brain. The mutation affects a multi-step process and eventually causes protein to clog the doorways into the cell.<\/p>\n<p><a href=\"https:\/\/today.uconn.edu\/2021\/09\/researchers-show-how-protein-clogs-in-cellular-entrances-cause-parkinsons-disease\/\">Read more<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>As posted in UConn Today September 15, 2021 | Kim Krieger UConn Communications &nbsp; &nbsp; Mutations in a protein known to cause Parkinson\u2019s Disease derange transportation in and out of brain cells, reports a team of UConn Health researchers in\u00a0the 27 July issue of Science Signaling. The toxic traffic jams that result eventually lead to [&hellip;]<\/p>\n","protected":false},"author":97,"featured_media":4702,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"wds_primary_category":0,"footnotes":""},"categories":[4,1],"tags":[],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-23 11:17:47","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/posts\/4995"}],"collection":[{"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/users\/97"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/comments?post=4995"}],"version-history":[{"count":3,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/posts\/4995\/revisions"}],"predecessor-version":[{"id":4999,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/posts\/4995\/revisions\/4999"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/media\/4702"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/media?parent=4995"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/categories?post=4995"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/tags?post=4995"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}