{"id":2554,"date":"2017-01-30T11:32:07","date_gmt":"2017-01-30T16:32:07","guid":{"rendered":"http:\/\/neuroscience.uchc.edu\/?p=2554"},"modified":"2017-11-03T14:30:23","modified_gmt":"2017-11-03T18:30:23","slug":"multiple-sclerosis-researchers-at-uconn-health-make-strides-to-help-ms-patients","status":"publish","type":"post","link":"https:\/\/health.uconn.edu\/neuroscience\/2017\/01\/30\/multiple-sclerosis-researchers-at-uconn-health-make-strides-to-help-ms-patients\/","title":{"rendered":"New Study Gives Hope to Multiple Sclerosis Patients"},"content":{"rendered":"<h3>Researchers at the UConn School of Medicine Use Patient\u2019s Own Adult Stem Cells to Identify Defect Linked to Myelin Loss in MS<\/h3>\n<figure id=\"attachment_2562\" aria-describedby=\"caption-attachment-2562\" style=\"width: 239px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2562 lazyload\" data-src=\"https:\/\/health.uconn.edu\/neuroscience\/wp-content\/uploads\/sites\/121\/2017\/01\/Crocker-lab-MS-storycroppedweb.gif\" alt=\"Multiple Sclerosis group\" width=\"239\" height=\"164\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 239px; --smush-placeholder-aspect-ratio: 239\/164;\" \/><noscript><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2562 \" src=\"https:\/\/health.uconn.edu\/neuroscience\/wp-content\/uploads\/sites\/121\/2017\/01\/Crocker-lab-MS-storycroppedweb.gif\" alt=\"Multiple Sclerosis group\" width=\"239\" height=\"164\" \/><\/noscript><figcaption id=\"caption-attachment-2562\" class=\"wp-caption-text\">Left to Right: Cory Willis (Crocker Lab), Dr. Rosa Guzzo, Alexandra Nicaise (Crocker Lab), Dr. Matthew Tremblay and Dr. Stephen Crocker (Photo courtesy: J. Gridley)<\/figcaption><\/figure>\n<p>In a report to be\u00a0published in the journal Experimental Neurology on\u00a0February 1, 2017, researchers in the Department of Neuroscience have\u00a0determined that cells from patients with multiple sclerosis (MS)\u00a0have an inherent defect in their ability to promote myelin &#8211; the brain tissue damaged in this disease.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27865736\">iPS-derived neural progenitor cells from PPMS patients reveal defect in myelin injury response.<\/a><\/p>\n<p><a href=\"http:\/\/facultydirectory.uchc.edu\/profile?profileId=Crocker-Stephen\">Dr. Stephen J. Crocker<\/a>, the lead investigator and\u00a0senior author\u00a0of this study, in collaboration with UConn Neurology and The Mandell Center for Multiple Sclerosis, Mount Sinai Rehabilitation Hospital in\u00a0Hartford, developed new induced\u00a0stem cell\u00a0(iPS)\u00a0lines from patient&#8217;s own blood samples. Using these in the lab\u00a0they were able to make brain stem cells which may be the next step to unlocking a treatment for this disease.<\/p>\n<p>Data from this study shows that the benefit of certain\u00a0experimental drugs which have been suggested to promote brain repair in MS may not work in patients with the progressive form of this disease. However, ongoing studies in the Crocker Lab have found that by using these iPS they can mimic the environment of the diseased brain which is leading to identification of new drugs which could have a better chance at treating the brain damage in these patients.<\/p>\n<p>Other authors of this study included Alexandra Nicaise, B.S. (first author), Cory Willis,\u00a0B.S.\u00a0Kasey Johnson, Ph.D. (graduate students), Kristen Russomano, B.S. (UConn medical student),\u00a0Erin Banda,\u00a0M.S. technician, Wanda Castro, M.D., former UConn neurologist, Albert Lo,\u00a0M.D., PhD., Director of Research at the Mandell MS clinic, and Rosa Guzzo, Ph.D., Assistant Professor, Department of Neuroscience.<\/p>\n<p>For comment on this study, please contact <a href=\"http:\/\/facultydirectory.uchc.edu\/profile?profileId=Tremblay-Matthew\">Dr. Matthew Tremblay<\/a>, UConn Health&#8217;s newest faculty member in the Neurology Multiple Sclerosis clinic, <a href=\"mailto:mtremblay@uchc.edu\">mtremblay@uchc.edu<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a report to be published in the journal Experimental Neurology on Feb 1, 2017, researchers in the Department of Neuroscience have determined that cells from patients with multiple sclerosis (MS) have an inherent defect in their ability to promote myelin &#8211; the brain tissue damaged in this disease. <\/p>\n","protected":false},"author":97,"featured_media":2567,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"wds_primary_category":0,"footnotes":""},"categories":[4],"tags":[],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-08 05:41:07","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/posts\/2554"}],"collection":[{"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/users\/97"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/comments?post=2554"}],"version-history":[{"count":3,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/posts\/2554\/revisions"}],"predecessor-version":[{"id":3438,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/posts\/2554\/revisions\/3438"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/media\/2567"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/media?parent=2554"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/categories?post=2554"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/tags?post=2554"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}