{"id":969,"date":"2015-06-25T10:50:54","date_gmt":"2015-06-25T14:50:54","guid":{"rendered":"http:\/\/neuroscience.uchc.edu\/\/?page_id=969"},"modified":"2024-09-30T09:23:33","modified_gmt":"2024-09-30T13:23:33","slug":"research-interests","status":"publish","type":"page","link":"https:\/\/health.uconn.edu\/neuroscience\/research\/research-interests\/","title":{"rendered":"Neuroscience Research Programs"},"content":{"rendered":"<div id=\"pl-969\"  class=\"panel-layout\" ><div id=\"pg-969-0\"  class=\"panel-grid panel-has-style\" ><div class=\"panel-row-style panel-row-style-for-969-0\" ><div id=\"pgc-969-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-969-0-0-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child\" data-index=\"0\" ><div class=\"panel-widget-style panel-widget-style-for-969-0-0-0\" ><h3 class=\"widget-title\">Research Goals<\/h3><div class=\"textwidget\"><p><figure id=\"attachment_1505\" aria-describedby=\"caption-attachment-1505\" style=\"width: 993px\" class=\"wp-caption alignnone\"><a href=\"https:\/\/health.uconn.edu\/neuroscience\/wp-content\/uploads\/sites\/121\/2015\/06\/1dinj-GFAP-Mosaic.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1505 lazyload\" data-src=\"https:\/\/health.uconn.edu\/neuroscience\/wp-content\/uploads\/sites\/121\/2015\/06\/1dinj-GFAP-Mosaic-1024x311.jpg\" alt=\"1dinj GFAP Mosaic\" width=\"993\" height=\"301\" data-srcset=\"https:\/\/health.uconn.edu\/neuroscience\/wp-content\/uploads\/sites\/121\/2015\/06\/1dinj-GFAP-Mosaic-1024x311.jpg 1024w, https:\/\/health.uconn.edu\/neuroscience\/wp-content\/uploads\/sites\/121\/2015\/06\/1dinj-GFAP-Mosaic-300x91.jpg 300w, https:\/\/health.uconn.edu\/neuroscience\/wp-content\/uploads\/sites\/121\/2015\/06\/1dinj-GFAP-Mosaic-768x234.jpg 768w\" data-sizes=\"(max-width: 993px) 100vw, 993px\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 993px; --smush-placeholder-aspect-ratio: 993\/301;\" \/><noscript><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1505 \" src=\"https:\/\/health.uconn.edu\/neuroscience\/wp-content\/uploads\/sites\/121\/2015\/06\/1dinj-GFAP-Mosaic-1024x311.jpg\" alt=\"1dinj GFAP Mosaic\" width=\"993\" height=\"301\" srcset=\"https:\/\/health.uconn.edu\/neuroscience\/wp-content\/uploads\/sites\/121\/2015\/06\/1dinj-GFAP-Mosaic-1024x311.jpg 1024w, https:\/\/health.uconn.edu\/neuroscience\/wp-content\/uploads\/sites\/121\/2015\/06\/1dinj-GFAP-Mosaic-300x91.jpg 300w, https:\/\/health.uconn.edu\/neuroscience\/wp-content\/uploads\/sites\/121\/2015\/06\/1dinj-GFAP-Mosaic-768x234.jpg 768w\" sizes=\"(max-width: 993px) 100vw, 993px\" \/><\/noscript><\/a><figcaption id=\"caption-attachment-1505\" class=\"wp-caption-text\">Immunofluorescent images of injured mice retina. Seven days after injury, the mouse eye exhibits long GFAP filaments throughout the layers of the retina. Cell nuclei can be observed in three layers of the retina, with filaments from M\u00fcller glia providing structure to the eye.<\/figcaption><\/figure><\/p>\n<p><span>The Neuroscience Department is an interdisciplinary and interdepartmental program. The goal of research in this program is to understand the development, organization, function, and dysfunction of the nervous system at the molecular, cellular, systems, and whole animal levels. Molecular, electrophysiological, behavioral, genetic, confocal imaging, and stem or virtual cell approaches are employed, as well as cellular, animal, transgenic, and mathematical models. The breadth of this program is depicted in a survey of the numerous topics covered by faculty research, which include: stem and precursor cell biology as it pertains to gliogenesis and neurogenesis in the developing nervous system; biochemistry and regulation of gene expression, signal transduction, and intracellular trafficking in neurons and glia; structure and function of voltage-sensitive ion channels; synthesis, storage and secretion of neuropeptides; neurotransmission and plasticity; synaptic organization and stimulus coding; sensory perception, behavioral neuroscience and human psychophysics; neuroinflammation, autoimmunity, and neurodegeneration; the biology of substance abuse and biomarker imaging. Research pertaining to specific diseases or disorders include: substance abuse,\u00a0stroke, epilepsy, multiple sclerosis, blindness, and deafness.<\/span><\/p>\n<\/div><\/div><\/div><div id=\"panel-969-0-0-1\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-last-child\" data-index=\"1\" ><h3 class=\"widget-title\">Neuroscience Research Areas<\/h3><div class=\"textwidget\"><p>The discipline of neuroscience examines nervous system function at numerous levels, incorporating a molecular and cellular viewpoint on the one hand and an integrative systems approach on the other. It is the goal of modern neuroscience research to integrate the two sides of this neurological coin into a consistent continuum, one that blends neurochemistry, developmental neurobiology, neuropharmacology, neurophysiology, neuroanatomy, and behavior neuroscience into a seamless intellectual construct capable of generating novel, testable hypotheses of how these individual disciplines are coordinated to produce the remarkable machine we call the nervous system. The Department of Neuroscience at UConn Health\u00a0has applied these principles in the development of an equally integrated community of neuroscience investigators, with special strengths in the following areas of research:\u00a0<strong><a href=\"https:\/\/health.uconn.edu\/neuroscience\/?p=5309\">Cellular &amp; Molecular<\/a>, <a href=\"https:\/\/health.uconn.edu\/neuroscience\/?page_id=7120&amp;preview=true\"><strong>Circuit &amp; Systems Neuroscience<\/strong><\/a>, <a href=\"https:\/\/health.uconn.edu\/neuroscience\/research\/research-interests\/developmental-research\/\">Developmental Neuroscience<\/a>, <a href=\"https:\/\/health.uconn.edu\/neuroscience\/research\/research-interests\/cellular-and-molecular-research\/\">Neurodegenerative Diseases<\/a>, <a href=\"https:\/\/health.uconn.edu\/neuroscience\/research\/research-interests\/neurological-disease-research\/\" class=\"broken_link\">Neurodevelopmental Diseases<\/a>,\u00a0<a href=\"https:\/\/health.uconn.edu\/neuroscience\/research\/research-interests\/neurotransmission-research\/\">Neurotransmission Research<\/a>, <a href=\"https:\/\/health.uconn.edu\/neuroscience\/research\/research-interests\/psychiatric-disorders\/\">Psychiatric Disorders<\/a> and <a href=\"https:\/\/health.uconn.edu\/neuroscience\/research\/research-interests\/sensory-processing-research\/\">Sensory Pathologies<\/a>.<\/strong><\/p>\n<p>&nbsp;<\/p>\n<div class=\"entry-content\">\n<div id=\"pl-5309\" class=\"panel-layout\">\n<div id=\"pg-5309-0\" class=\"panel-grid panel-no-style\">\n<div class=\"entry-content\">\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>The Neuroscience Department is an interdisciplinary and interdepartmental program. The goal of research in this program is to understand the development, organization, function, and dysfunction of the nervous system at the molecular, cellular, systems, and whole animal levels. Molecular, electrophysiological, behavioral, genetic, confocal imaging, and stem or virtual cell approaches are employed, as well as [&hellip;]<\/p>\n","protected":false},"author":38,"featured_media":0,"parent":389,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-29 10:48:31","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/pages\/969"}],"collection":[{"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/users\/38"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/comments?post=969"}],"version-history":[{"count":40,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/pages\/969\/revisions"}],"predecessor-version":[{"id":7334,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/pages\/969\/revisions\/7334"}],"up":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/pages\/389"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/neuroscience\/wp-json\/wp\/v2\/media?parent=969"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}