{"id":214,"date":"2017-04-20T09:38:22","date_gmt":"2017-04-20T13:38:22","guid":{"rendered":"https:\/\/health.uconn.edu\/mouse-genome-modification\/?p=214"},"modified":"2017-04-20T12:42:16","modified_gmt":"2017-04-20T16:42:16","slug":"gttf-mice-on-the-cover","status":"publish","type":"post","link":"https:\/\/health.uconn.edu\/mouse-genome-modification\/2017\/04\/20\/gttf-mice-on-the-cover\/","title":{"rendered":"GTTF Mice on the Cover"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-215 alignright\" src=\"https:\/\/health.uconn.edu\/mouse-genome-modification\/wp-content\/uploads\/sites\/134\/2017\/04\/image_canalis_JBC_january22_cover.jpg\" alt=\"Journal of Biological Chemistry\" width=\"283\" height=\"371\" srcset=\"https:\/\/health.uconn.edu\/mouse-genome-modification\/wp-content\/uploads\/sites\/134\/2017\/04\/image_canalis_JBC_january22_cover.jpg 283w, https:\/\/health.uconn.edu\/mouse-genome-modification\/wp-content\/uploads\/sites\/134\/2017\/04\/image_canalis_JBC_january22_cover-229x300.jpg 229w\" sizes=\"(max-width: 283px) 100vw, 283px\" \/><\/p>\n<p>Mice harboring a gain-of-function Notch2 mutation recapitulate selected skeletal manifestations of Hajdu-Cheney syndrome. Image of a femoral cross-section (bone marrow cells in green, bone surface with osteoblasts in purple and red, osteoclasts in yellow) from a mutant mouse.<\/p>\n<p>Canalis E, Schilling L, Yee SP, Lee SK, Zanotti S., (2016). Hajdu Cheney Mouse Mutants Exhibit Osteopenia, Increased Osteoclastogenesis and Bone Resorption. J. Biol. Chem. 291: 1538-1551.<\/p>\n<p><!--more--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mice harboring a gain-of-function Notch2 mutation recapitulate selected skeletal manifestations of Hajdu-Cheney syndrome.<\/p>\n","protected":false},"author":38,"featured_media":215,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"wds_primary_category":0,"footnotes":""},"categories":[1],"tags":[],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-29 20:20:57","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/mouse-genome-modification\/wp-json\/wp\/v2\/posts\/214"}],"collection":[{"href":"https:\/\/health.uconn.edu\/mouse-genome-modification\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/health.uconn.edu\/mouse-genome-modification\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/mouse-genome-modification\/wp-json\/wp\/v2\/users\/38"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/mouse-genome-modification\/wp-json\/wp\/v2\/comments?post=214"}],"version-history":[{"count":4,"href":"https:\/\/health.uconn.edu\/mouse-genome-modification\/wp-json\/wp\/v2\/posts\/214\/revisions"}],"predecessor-version":[{"id":229,"href":"https:\/\/health.uconn.edu\/mouse-genome-modification\/wp-json\/wp\/v2\/posts\/214\/revisions\/229"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/mouse-genome-modification\/wp-json\/wp\/v2\/media\/215"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/mouse-genome-modification\/wp-json\/wp\/v2\/media?parent=214"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/health.uconn.edu\/mouse-genome-modification\/wp-json\/wp\/v2\/categories?post=214"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/health.uconn.edu\/mouse-genome-modification\/wp-json\/wp\/v2\/tags?post=214"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}