{"id":13,"date":"2017-04-17T14:01:49","date_gmt":"2017-04-17T18:01:49","guid":{"rendered":"https:\/\/health.uconn.edu\/mouse-genome-modification\/?page_id=13"},"modified":"2026-03-24T09:49:30","modified_gmt":"2026-03-24T13:49:30","slug":"publications","status":"publish","type":"page","link":"https:\/\/health.uconn.edu\/mouse-genome-modification\/publications\/","title":{"rendered":"Publications Using CMGM Mice"},"content":{"rendered":"
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Ernesto Canalis, Jungeun Yu, Emily Denker, Lauren Schilling, Alix Deymier, Bing Hao, Thomas Carpenter. <\/span>A novel variant of NOTCH2 causes skeletal fragility\u00a0 <\/a>Bone. 2025 Nov 2;202:117702. doi:<\/span>10.1016\/j.bone.2025.117702<\/a><\/p>\n

Yasuyuki Fujii<\/span>1<\/span>, Iichiro Okabe<\/span>1<\/span>, Ayano Hatori<\/span>1<\/span>, Shyam Kishor Sah<\/span>1<\/span>, Jitendra Kanaujiya<\/span>2<\/span>, Melanie Fisher<\/span>2<\/span>, Rachael Norris<\/span>2<\/span>, Mark Terasaki<\/span>2<\/span>, Ernst J. Reichenberger<\/span>3 <\/span>and I-Ping Chen <\/span>1,3 <\/span>\u2709 \u00a0<\/span>Skeletal abnormalities caused by a Connexin43R239Q mutation in a mouse model for autosomal recessive craniometaphyseal dysplasia<\/a>. Bone Research (2025)13:14 dot: 10.1038\/s41413-024-00383-z<\/div>\n<\/div>\n<\/div>\n<\/div>\n

Juan Enriquez-Traba 1,2,3, Miguel Arenivar1, Hector E. Yarur-Castillo 1,Chloe Noh1, Rodolfo J. Flores1, Tenley Weil 4, Snehashis Roy5, Ted B. Usdin 5, Christina T. LaGamma1, Huikun Wang1, Valerie S. Tsai 1, Damien Kerspern6, Amy E. Moritz7, David R. Sibley 7, Andrew Lutas 6, Rosario Moratalla 3, Zachary Freyberg 8,9 & Hugo A. Tejeda 1 Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors \u00a0<\/a>Nature Neuroscience doi: 10.1038 28<\/b>,\u00a0pages<\/span>105\u2013121 (2025<\/span>)<\/p>\n

Owen, C.M., Jaffe, L.A. 2025.\u00a0Luteinizing hormone-induced changes in the structure of mammalian preovulatory follicles..pdf<\/span><\/a>\u00a0Curr Top Dev Biol<\/em>.162:259-282<\/span>.<\/span><\/p>\n

Egbert, Jeremy R; Owen, Corie M; Uliasz, Tracy F; Kaback, Deborah; Yee, Siu-Pok; Jaffe,Laurinda A. <\/span>Testing the function of PPP-family phosphatases modified by luteinizing hormonesignaling in mouse ovarian follicles: an update<\/span>. Biology of reproduction<\/i> 2025<\/span>Mar<\/span> DOI: <\/span>10.1093\/biolre\/ioaf076<\/a><\/p>\n

Hiu W. Cheung, Alexander D. Schouw, Zeynep M. Altunay, J. Wesley Maddox, Lyndsay C. Kresic, Brenna C. McAllister, Keaven Caro, Shahnawaz Alam, Angie Huang, Robert S. Pijewski, Amy Lee, David C. Martinelli. (2024) Creation of a novel CRISPR-generated allele to express HA epitope-tagged C1QL1 and improved methods for its detecion at synapses<\/a>. FEBS PRESS 10 June 2024 doi:10.1002\/1873-3468.14946<\/span><\/p>\n

Corie M Owen, Laurinda A Jaffe. (2024) Luteinizing hormone stimulates ingression of mural granulosa cells within the mouse preovulatory follicle<\/a>. Biol Reprod.<\/em> Feb 10;110(2):288-299. doi:10.1093\/biolre\/ioad142. <\/span><\/p>\n

Rachael P Norris, Laurinda A Jaffe. (2024) Granulosa Cells Alone, Without Theca Cells, Can Mediate LH-induced Oocyte Meiotic Resumption<\/a>. Endocrinology<\/em>. Jan 16;165(3):bqad200. doi:10.1210\/endocr\/bqad200.<\/span><\/p>\n

Nicholes R. Candelaria, JoAnne S Richards. (2024) Targeted deletion of NR2F2 and VCAM1 in theca cells imacts ovarian follicular development: insights into PCOS?<\/a> Biol Reprod<\/em>. Jan 15:ioae010. doi:10.1093\/biolre\/ioae010.<\/span><\/p>\n

Lisa M Mehlman, Tracy F Uliasz, Siu-Pok Yee, Deborah Kaback, Katie M Lowther(2024) Generation and Characterization of a TRIM21 Overexpressing Mouse Line<\/a>. Genesis<\/em>. 2024 Oct;62(5):e23616. doi:10.1002\/dvg.23616<\/p>\n

Pearl A Sutter, Cory M Willis, Antione Menoret, Alexandra M Nicaise, Anthony Sacino, Arend H Sikkema, Evan R Jellison, Kyaw K Win, David K Han, William Church, Wia Baron, Anthony T Vella, Stephen J Crocker. (2024) Astrocytic TIMP-1 regulates production of Anastellin, an inhibitor of oligodendrocyte differentiation and RTY720 responses <\/a>PNAS. <\/em>2024 Jan 24;121(5):e2306816121. doi:10.1073\/pnas.2306816121<\/span><\/p>\n

Egbert JR, Silbern I, Uliasz TF, Lowther KM, Yee SP, Urlaub H, Jaffe LA.(2023)<\/span> Phosphatases modified by LH signaling in ovarian follicles: testing their role in regulating the NPR2 guanylyl cyclase<\/a>\u00a0Biol Reprod<\/em>. 2023 Sep 29:ioad130. doi: 10.1093\/biolre\/ioad130. Online ahead of print.<\/span> PMID: <\/span>37774352<\/span><\/p>\n

Seetur R.<\/span>\u00a0Pradeep<\/span>,\u00a0Mahesh\u00a0Thirunavukkarasu,\u00a0Diego\u00a0Accorsi,\u00a0Santosh\u00a0Swaminathan,\u00a0Sue Ting\u00a0Lim,\u00a0Bryan\u00a0Cernuda,\u00a0Andrew\u00a0Kemerley,\u00a0Jennifer\u00a0Hubbard,\u00a0Jacob\u00a0Campbell,\u00a0Rickesha L.\u00a0Wilson,\u00a0Vladimir\u00a0Coca-Soliz,\u00a0Leondidas\u00a0Tapias,\u00a0Vaithinathan\u00a0Selvaraju,\u00a0Evan R.\u00a0Jellison,\u00a0Siu-Pok\u00a0Yee,\u00a0J. Alexander\u00a0Palesty,\u00a0Nilanjana\u00a0Maulik\u00a0<\/span> (2023)\u00a0<\/span>Novel approaches to determine the functional role of cardiomyocyte specific E3 ligase, Pellino-1 following myocardial infarction<\/a>.<\/span>\u00a02023 Sep 29:166899. <\/span>doi: 10.1016\/j.bbadis.2023.166899.<\/span>\u00a0<\/span>Online ahead of print.<\/span><\/span><\/p>\n

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Mahesh Thirunavukkarasu, Santosh Swaminathan, Andrew Kemerley, Seetur R Pradeep, Sue Ting Lim, Diego Accorsi, Rickesha Wilson, Jacob Campbell, Ibnalwalid Saad, Siu-Pok Yee, J Alexander Palesty, David W McFadden , Nilanjana Maulik (2023) Role of Pellino-1 in Inflammation and Cardioprotection following Severe Sepsis: A Novel Mechanism in a Murine Severe Sepsis Model<\/a>. <\/span>Cells 2023 June 1;12(11):1527. doi:10.3390\/cells1211527
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Yi Tian Yap, <\/span><\/span><\/span>Wei Li,<\/span> <\/span>Qian Huang,<\/span> <\/span>Qi Zhou,<\/span> <\/span>David Zhang,<\/span> <\/span>Yi Sheng, <\/span><\/span>Ljljiana Mladenovic-Lucas,<\/span> <\/span>Siu-Pok Yee,<\/span> <\/span>Kyle E Orwig,<\/span> <\/span>James G Granneman,<\/span> <\/span>David C Williams Jr,<\/span> <\/span>Rex Hess,<\/span> <\/span>Aminata Toure,<\/span> <\/span>Zhibing Zhang\u00a0<\/span>(2023) DNALI1 interacts with the MEIG1\/PACRG complex within the manchette and is required for proper sperm flagellum assembly in mice.<\/a> Apr 21, 2023.\u00a0<\/span>https:\/\/doi.org\/10.7554\/eLife.79620.<\/span><\/p>\n

Yonghong Man, Wei Li, Yi Tian Yap, Alivia Kearney, Siu-Pok Yee, Jerome F. Strauss III, Pamela Harding, Shizheng Song, Ling Zhang, Zhibing Zhang (2023) Generation of floxed Spag6l<\/em> mice and disruption of the gene by crossing to a Hprt-Cre<\/em> line<\/a>.\u00a0<\/span><\/span>2023 Apr 14;e23512. <\/span>doi: 10.1002\/dvg.23512.<\/span>\u00a0<\/span>Online ahead of print.<\/span><\/p>\n

Masakazu Yamamoto, Sean J Stoessel, Shoko Yamamoto, and David J Goldhamer (2022) Overexpression of Wild-Type ACVR1\u00a0<\/em>in Fibrodysplasia Ossificans Progressive Mice Rescues Perinatal Lethality and Inhibits Heterotopic Ossification.<\/a> J Bone Miner Res. 2022 Nov; 37(11):2077-2093.<\/p>\n

Jeremy R. Egbert, Tracy F. Uliasz, Katie M. Lowther, Deborah Kaback, Brandon M. Wagner, Chastity L. Healy, Timothy D. O'Connell, Lincoln R. Potter, Laurinda A. Jaffe and Siu-Pok Yee (2022)\u00a0<\/a><\/span>Epitope-tagged and phosphomimetic mouse models for investigating natriuretic peptide-stimulated receptor guanylyl cyclases<\/a>. Front Mol Neurosci. 2022 Oct 19;15:1007026. doin: 10.3389\/fnmol.2022.100726. eCollection 2022.<\/p>\n

E. Canalis, S.P. Yee, A.N. Economdies, L. Schilling, J. Yu. Induction of a NOTCH3 Lehman syndrome mutation in osteocytes causes osteopenia in male C57BL\/6J mice<\/a>. (2022) Bone Volume 162, September 2022, 116476 doi 10.1016\/j.bone\/2022.116476<\/span><\/p>\n

John R Sinnamon,\u00a0<\/span><\/span>Michael E Jacobson,\u00a0<\/span><\/span>John F Yung,\u00a0<\/span><\/span>Jenna R Fisk,\u00a0<\/span><\/span>Sophia Jeng,\u00a0<\/span><\/span>Shannon K McWeeney,\u00a0<\/span><\/span>Lindsay K Parmelee,\u00a0<\/span><\/span>Chi Ngai Chan,\u00a0<\/span><\/span>Siu-Pok Yee,\u00a0<\/span><\/span>Gail Mandel (2022). <\/span>Targeted RNA editing in brainstem alleviates respiratory dysfunction in a mouse model of Rett syndrome.<\/a> Proc Natl Acad Sci USA.\u00a0<\/span><\/span>2022 Aug 16;119(33):e2206053119.<\/span>\u00a0<\/span>doi: 10.1073\/pnas.2206053119.<\/span>\u00a0<\/span>Epub 2022 Aug 8.<\/span><\/p>\n

Brandon M Wagner,\u00a0Jerid W Robinson,\u00a0Chastity L Healy,\u00a0Madeline Gauthier,\u00a0Deborah M Dickey,\u00a0Siu-Pok Yee,\u00a0John W Osborn,\u00a0Timothy D O'Connell, Lincoln R Potter <\/sup>(2022). Guanylyl cyclase-A phosphorylation decreases cardiac hypertrophy and improves systolic function in male, but not female, mice<\/a>.\u00a0FASEB J. <\/em>Jan;36(1):e22069.PMID: 34859913.<\/p>\n

Jeremy R Egbert,\u00a0Jerid W Robinson,\u00a0Tracy F Uliasz,\u00a0Lincoln R Potter, Laurinda A Jaffe (2021). Cyclic AMP links luteinizing hormone signaling to dephosphorylation and inactivation of the NPR2 guanylyl cyclase in ovarian follicles<\/a>\u2020 Biol Reprod. <\/em>May 7;104(5):939-941.<\/p>\n

Shuhaibar, L.C.,\u00a0\u00a0Kaci, N., Egbert, J.R., Horville, T., Loisay, L., Vigone, G., Uliasz, T.F., Dambroise,E., Swingle, M.R.,\u00a0 Honkanen, R.E., Duplan, M.B., Jaffe, L.A., Legeai-Mallet, L. (2021)\u00a0Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth<\/a>\u00a0JCI insight<\/em>. 6\u00a0(9):141426.<\/p>\n

Mallika Ghosh, Tomislav Kelava, Ivana Vrhovac Madunic, Ivo Kalajzic, Linda H Shapiro CD13 is a critical regulator of cell-cell fusion in osteoclastogenesis<\/a>. Sci Rep. 2021 May 24;11(1):10736. doi10.1038\/s41598-021-90271-x.<\/p>\n

JungeunYu12<\/sup><\/span>LaurenSchilling2<\/sup><\/span>TabithaEller2<\/sup><\/span>ErnestoCanalis123<\/sup><\/span>(2021). Hairy and enhancer of split 1 is a primary effector of NOTCH2 signaling and induces osteoclast differentiation and function.<\/a><\/span>\u00a0J Biol Chem. <\/em>Volume 297, Issue 6<\/a>,doi: 10.1016\/j.jbc.2021.101376.\u00a0Epub 2021 Nov 3.<\/p>\n

Yue Su<\/span>\u00a0<\/sup><\/span>,\u00a0<\/span>Ling Wang,<\/span>\u00a0<\/span>Zhiqiang Fan,<\/span>\u00a0<\/span>Ying Liu,<\/span>\u00a0<\/span>Jiaqi Zhu,<\/span>\u00a0<\/span>Deborah Kaback,<\/span>\u00a0<\/span>Julia Oudiz,<\/span>\u00a0<\/span>Tayler Patrick,<\/span>\u00a0<\/span>Siu Pok Yee,<\/span>\u00a0<\/span>Xiuchun Cindy Tian<\/span>,\u00a0<\/span>Irina Polejaeva,<\/span>\u00a0<\/span>Young Tang. <\/span>(2021) Establishment of Bovine-Induced Pluripotent Stem Cells.<\/a><\/span>\u00a0Int. J. Mol. Sci.<\/em>, 22<\/em>(19), 10489; https:\/\/doi.org\/10.3390\/ijms221910489<\/p>\n

Jessica Costa-Guda, Kristin Corrado, Justin Bellizzi, Robert Romano, Elizabeth Saria, Kirsten Saucier, Madison Rose, Samip Shah, Cynthia Alander, Sanjay Mallya, and Andrew Arnold. (2020) CDK4\/6 Dependence of Cyclin D1-Driven Parathyroid Neoplasia in Transgenic Mice<\/a>. Endocrinology, 2020 Oct; 161 (10): bpqaa159. doi: 10.1210\/endocr\/bqaa159.<\/span><\/p>\n

Qu W, Yuan S, Quan C, Huang Q, Zhou Q, Yap Y, Shi L, Zhang D, Guest T, Li W,<\/span>\u00a0<\/span>Yee SP, Zhang L, Cazin C, Hess RA, Ray PF, Kherraf ZE, Zhang Z.<\/span> (2020)\u00a0<\/span>The essential role of intraflagellar transport protein IFT81 in male mice spermiogenesis and fertility.<\/a> Am J Physiol Cell Physiol.<\/em> 318(6):C1092-C1106. doi: 10.1152\/ajpcell.00450.2019. Epub 2020 Apr 1.<\/span>PMID:<\/span>\u00a0<\/span>32233951<\/span><\/p>\n

Hrdlicka HC, Pereira RC, Shin B,\u00a0Yee SP, Deymier AC, Lee SK, Delany (2021)\u00a0<\/span>Inhibition of miR-29-3p isoforms via tough decoy suppresses osteoblast function in homeostasis but promotes intermittent parathyroid hormone-induced bone anabolism.<\/a> AM.<\/em><\/span>Bone<\/em>. 143:115779. doi: 10.1016\/j.bone.2020.115779. Epub 2020 Nov 28.<\/span>PMID:<\/span>\u00a0<\/span>33253931<\/span><\/p>\n

Li J, Liang CC, Pappas SS,\u00a0Dauer WT. (2020) <\/span>TorsinB overexpression prevents abnormal twisting in DYT1 dystonia mouse models.<\/a> Elife<\/em>. 23;9:e54285. doi: 10.7554\/eLife.54285.<\/span>PMID:<\/span>\u00a0<\/span>32202496<\/span>\u00a0<\/span><\/p>\n

Selvaraju, V., Thirunavukkarasu, M., Joshi, M., Oriowo, B., Shaikh, I.A., Rishi, M.T., Tapias, L., Coca-Soliz, V., Saad, I., Campbell, J., Pradeep, S.R., Swaminathan, S., Yee, S.P., McFadden, D., Alexander Palesty, J., Maulik, N. \u00a0(2020) Deletion of newly described pro-survival molecule Pellino-1 increases oxidative stress, downregulates cIAP2\/NF-kB cell survival pathway, reduces angiogenic response, and thereby aggravates tissue function in mouse ischemic models<\/a>.<\/span> Basic Res. Cardiol.<\/em> 115(4):45.<\/p>\n

Baena, V., Owen, C.M., Uliasz, T.F., Lowther, K.M., Yee, S.-P., Terasaski, M., Egbert, J.E., and Jaffe, L.A. (2020).\u00a0<\/span>Cellular heterogeneity of the LH receptor and its significance for cyclic GMP signaling in mouse preovulatory follicles.<\/a> Endocrinology 161(7):bqaa074.<\/em> Crispr\/CAS approach.<\/p>\n

Wei Qu,\u00a0<\/span><\/span>Shuo Yuan,\u00a0<\/span><\/span>Chao Quan,\u00a0<\/span><\/span>Qian Huang,\u00a0<\/span><\/span>Qi Zhou,\u00a0<\/span><\/span>Yitian Yap,\u00a0<\/span><\/span>Lin Shi,\u00a0<\/span><\/span>David Zhang,\u00a0<\/span><\/span>Tamia Guest,\u00a0<\/span><\/span>Wei Li,\u00a0<\/span><\/span>Siu-Pok Yee,\u00a0<\/span><\/span>Ling Zhang,\u00a0<\/span><\/span>Caroline Cazin,\u00a0<\/span><\/span>Rex A Hess,\u00a0<\/span><\/span>Pierre F Ray,\u00a0<\/span><\/span>Zine-Eddine Kherraf <\/span><\/sup>,\u00a0<\/span><\/span>Zhibing Zhang. (2020) <\/span>The essential role of intraflagellar transport protein IFT81 in male mice spermiogenesis and fertility.<\/a> Am J Physiol Cell Physiol<\/em>. <\/span>318(6):C1092-C1106.<\/span><\/p>\n

Robinson JW,\u00a0<\/span>Blixt NC,\u00a0<\/span>Norton A,\u00a0<\/span>Mansky KC,\u00a0<\/span>Ye Z,\u00a0<\/span>Aparicio C,\u00a0<\/span>Wagner BM,\u00a0<\/span>Benton AM,\u00a0<\/span>Warren GL,\u00a0<\/span>Khosla S,\u00a0<\/span>Gaddy D,\u00a0<\/span>Suva LJ,\u00a0<\/span>Potter LR. (2020) <\/span>Male mice<\/span>\u00a0<\/span>with\u00a0<\/span>elevated<\/span>\u00a0<\/span>C-type<\/span>\u00a0<\/span>natriuretic peptide-dependent guanylyl cyclase-B activity have increased osteoblasts, bone mass and bone strength<\/a>.\u00a0Bone.<\/span><\/em> 135:115320.\u00a0<\/span><\/p>\n

Uyhazi KE,\u00a0<\/span>Yang Y,\u00a0<\/span>Liu N,\u00a0<\/span>Qi H,\u00a0<\/span>Huang XA,\u00a0<\/span>Mak W,\u00a0<\/span>Weatherbee SD,\u00a0<\/span>de Prisco N,\u00a0<\/span>Gennarino VA,\u00a0<\/span>Song X,\u00a0<\/span>Lin H. (2020) <\/span>Pumilio proteins utilize distinct regulatory mechanisms to achieve complementary functions required for pluripotency and embryogenesis<\/a>. Proc Natl Acad Sci U S A<\/em>.<\/span> 117(14):7851-7862.<\/span><\/p>\n

Galmozzi A,\u00a0<\/span>Kok BP,\u00a0<\/span>Kim AS,\u00a0<\/span>Montenegro-Burke JR,\u00a0<\/span>Lee JY,\u00a0<\/span>Spreafico R,\u00a0<\/span>Mosure S,\u00a0<\/span>Albert V,\u00a0<\/span>Cintron-Colon R,\u00a0<\/span>Godio C,\u00a0<\/span>Webb WR,\u00a0<\/span>Conti B,\u00a0<\/span>Solt LA,\u00a0<\/span>Kojetin D,\u00a0<\/span>Parker CG,\u00a0<\/span>Peluso JJ,\u00a0<\/span>Pru JK,\u00a0<\/span>Siuzdak G,\u00a0<\/span>Cravatt B, Saez E. <\/span>(2019) PGRMC2 is an intracellular haem chaperone critical for adipocyte function.<\/a> Nature<\/em>. <\/span>576(7785):138-142.<\/span><\/p>\n

Oakie A,\u00a0Feng ZC,\u00a0Li J,\u00a0Silverstein J,\u00a0Yee SP, Wang R. (2019)\u00a0Long-term c-Kit overexpression in beta cells compromises their function in ageing mice.<\/a> Diabetologia<\/em>. 62:1430-1444.<\/p>\n

Zhou Y, Dhaher R, Parent M, Hu QX, Hassel B,\u00a0Yee SP, Hyder F, Gruenbaum SE, Eid T, Danbolt NC. (2019)\u00a0Selective deletion of glutamine synthetase in the mouse cerebral cortex induces glial dysfunction and vascular impairment that precede epilepsy and neurodegeneration.<\/a>\u00a0\u00a0Neurochem Int.\u00a0<\/em>123:22-33.<\/p>\n

Jiang DY, Wu Z, Forsyth CT, Hu Y,\u00a0Yee SP, Chen G. (2018)\u00a0GABAergic deficits and schizophrenia-like behaviors in a mouse model carrying patient-derived neuroligin-2 R215H mutation.<\/a> Mol Brain<\/em>. 11:31.<\/p>\n

Canalis E, Yu J, Schilling L,\u00a0Yee SP, Zanotti S. (2018)\u00a0The lateral meningocele syndrome mutation causes marked osteopenia in mice.<\/a>\u00a0\u00a0J Biol Chem<\/em>. 293:14165-14177. CRISPR\/Cas9 approach.<\/p>\n

Thirunavukkarasu M, Selvaraju V, Joshi M, Coca-Soliz V, Tapias L, Saad I, Fournier C, Husain A, Campbell J,\u00a0Yee SP, Sanchez JA, Palesty JA, McFadden DW, Maulik N. (2018)\u00a0Disruption of VEGF Mediated Flk-1 Signaling Leads to a Gradual Loss of Vessel Health and Cardiac\u00a0Function During Myocardial Infarction: Potential Therapy With Pellino-1.<\/a>\u00a0J Am Heart Assoc<\/em>. Sep 18;7(18):e007601.<\/p>\n

Schmidt H,\u00a0Dickey DM,\u00a0Dumoulin A,\u00a0Octave M,\u00a0Robinson JW,\u00a0K\u00fchn R,\u00a0Feil R,\u00a0Potter LR,\u00a0Rathjen FG. (2018) Regulation of the natriuretic peptide receptor 2 (Npr2) by phosphorylation of juxtamembrane serine and threonine residues is essential for bifurcation of sensory axons.<\/a> J. Neurosci.,<\/em> 38:9768-9780.<\/p>\n

Yu J,\u00a0Zanotti S,\u00a0Schilling L,\u00a0Schoenherr C,\u00a0Economides AN,\u00a0Sanjay A,\u00a0Canalis E.\u00a0(2018) <\/span>I<\/span>nduction of the Hajdu-Cheney Syndrome Mutation in CD19 B Cells in Mice Alters B-Cell Allocation but Not Skeletal Homeostasis<\/a>.\u00a0Am J Pathol.\u00a0<\/span><\/em>188:1430-1446.<\/p>\n

Yu J,\u00a0Zanotti S,\u00a0Walia B,\u00a0Jellison E,\u00a0Sanjay A,\u00a0Canalis E. (2018) The Hajdu Cheney Mutation Is a Determinant of B-Cell Allocation of the Splenic Marginal Zone.<\/a> Am J Pathol.<\/span><\/em>\u00a0188:149-159.<\/p>\n

Choudhary S,\u00a0Santone E, Yee SP, Lorenzo\u00a0J, Adams DJ,\u00a0Goetjen A, McCarthy MB, Mazzocca AD,\u00a0Pilbeam C. (2018) Continuous PTH in Male Mice Causes Bone Loss Because It Induces Serum Amyloid A (SAA)<\/a>.\u00a0Endocrinology<\/em>,\u00a0Jul;159(7):2759-2776.<\/span> CRISPR\/Cas9 approach.<\/p>\n

Egbert JR, Yee SP and Jaffe LA. (2018) Luteinizing hormone signaling phosphorylates and activates the cyclic GMP phosphodiesterase PDE5 in mouse ovarian follicles, contributing an additional component to the hormonally induced decrease in cyclic GMP that reinitiates meiosis<\/a>. Dev. Biol.<\/i>,\u00a0 435:6-14. CRISPR\/Cas9 approach.<\/p>\n

Park JW, Yan L, Stoddard C, Wang X, Yue Z, Crandall L, Robinson T, Chang Y, Denton K, Li E, Jiang B, Zhang Z, Martins-Taylor K, Yee S, Nie H, Gu F, Si W, Xie T, Yue L, and Xu R. (2017) Recapitulating and Correcting Marfan Syndrome in a Cellular Model<\/a>. Int. J. Biol. Sci.<\/i> 13:588-603. Talen approach.<\/p>\n

Smith SA, Samokhin AO, Alfadi M, Murphy EC, Rhodes D, Holcombe WML, Kiss-Toth E, Storey RF, Yee SP, Francis SE, and Qwarnstrom EE. (2017)\u00a0\u00a0The IL-1RI Co-Receptor TILRR (FREM1 Isoform 2) Controls Aberrant Inflammatory Responses and Development of Vascular Disease<\/a>. J Am Coll Cardiol Basic Trans Sci. <\/i>2:398\u2013414.<\/p>\n

Shuhaibar LC, Robinson JW, Vigone G, Shuhaibar NP, Egbert JR, Baena V, Uliasz TF, Kaback D, Yee SP, Feil R, Fisher MC, Dealy CN, Potter LR, Jaffe, L.A. (2017) Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor<\/a>.\u00a0<\/span>e<\/i>L<\/i>i<\/i>fe<\/i><\/i>; 6: e31343.<\/p>\n

Clark NC, Pru CA, Yee SP, Lydon JP, Peluso JJ, Pru JK.(2017)\u00a0Conditional Ablation of Progesterone Receptor Membrane Component 2 Causes Female Premature Reproductive Senescence<\/a>. Endocrinology<\/em>.\u00a0158(3):640-651.<\/p>\n

McCallum ML, Pru CA, Niikura Y, Yee SP, Lydon JP, Peluso JJ, Pru JK. (2016)\u00a0Conditional Ablation of Progesterone Receptor Membrane Component 1 Results in Subfertility in the Female and Development of Endometrial Cysts<\/a>.\u00a0Endocrinology.\u00a0<\/em>157(9):3309-19.<\/p>\n

Enkhmandakh B, Stoddard C, Mack K, He W, Kaback D, Yee SP, Bayarsaihan D. (2016)\u00a0Generation of a Mouse Model for a Conditional Inactivation of Gtf2i Allele<\/a>. Genesis.\u00a0<\/em>54:407-12.<\/p>\n

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 <\/p>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

Ernesto Canalis, Jungeun Yu, Emily Denker, Lauren Schilling, Alix Deymier, Bing Hao, Thomas Carpenter. A novel variant of NOTCH2 causes skeletal fragility\u00a0 Bone. 2025 Nov 2;202:117702. doi:10.1016\/j.bone.2025.117702 Yasuyuki Fujii1, Iichiro Okabe1, Ayano Hatori1, Shyam Kishor Sah1, Jitendra Kanaujiya2, Melanie Fisher2, Rachael Norris2, Mark Terasaki2, Ernst J. Reichenberger3 and I-Ping Chen 1,3 \u2709 \u00a0Skeletal abnormalities caused […]<\/p>\n","protected":false},"author":38,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-16 17:04:46","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/mouse-genome-modification\/wp-json\/wp\/v2\/pages\/13"}],"collection":[{"href":"https:\/\/health.uconn.edu\/mouse-genome-modification\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/health.uconn.edu\/mouse-genome-modification\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/mouse-genome-modification\/wp-json\/wp\/v2\/users\/38"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/mouse-genome-modification\/wp-json\/wp\/v2\/comments?post=13"}],"version-history":[{"count":127,"href":"https:\/\/health.uconn.edu\/mouse-genome-modification\/wp-json\/wp\/v2\/pages\/13\/revisions"}],"predecessor-version":[{"id":1275,"href":"https:\/\/health.uconn.edu\/mouse-genome-modification\/wp-json\/wp\/v2\/pages\/13\/revisions\/1275"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/mouse-genome-modification\/wp-json\/wp\/v2\/media?parent=13"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}