{"id":392,"date":"2025-07-31T17:43:45","date_gmt":"2025-07-31T21:43:45","guid":{"rendered":"https:\/\/health.uconn.edu\/li-lab\/?p=392"},"modified":"2025-08-19T13:45:54","modified_gmt":"2025-08-19T17:45:54","slug":"new-paper-published-in-nature-neuroscience","status":"publish","type":"post","link":"https:\/\/health.uconn.edu\/li-lab\/2025\/07\/31\/new-paper-published-in-nature-neuroscience\/","title":{"rendered":"Our paper is accepted by Nature Neuroscience"},"content":{"rendered":"<p>We are thrilled to share that our research article, \u201c<em>FOXP<\/em> genes regulate Purkinje cell diversity in cerebellar development \u201d, has been accepted for publication in <em>Nature Neuroscience.<\/em><\/p>\n<p>Originally posted as a preprint on <em>bioRxiv<\/em>, this study combines single-cell transcriptomics and spatial proteomics to reveal the previously unrecognized diversity of Purkinje cell subtypes and their spatial organization in the embryonic mouse cerebellum. We demonstrate that this cellular heterogeneity is closely linked to cerebellar patterning and adult organization, and is orchestrated by the combinatorial activity of <em>Foxp<\/em> genes. These findings uncover fundamental molecular programs driving cerebellar development and provide new insights into the evolution of cerebellar complexity.<\/p>\n<p>Congratulations to Nagham Farah on her second high-profile first-author publication! Her creativity and perseverance were essential to the success of this work.<\/p>\n<p>We are grateful to our collaborators and all who contributed, and we look forward to sharing the final published version soon.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>We are thrilled to share that our research article, \u201cFOXP genes regulate Purkinje cell diversity in cerebellar development \u201d, has been accepted for publication in Nature Neuroscience. Originally posted as a preprint on bioRxiv, this study combines single-cell transcriptomics and spatial proteomics to reveal the previously unrecognized diversity of Purkinje cell subtypes and their spatial [&hellip;]<\/p>\n","protected":false},"author":2764,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"wds_primary_category":0,"footnotes":""},"categories":[1],"tags":[],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-02 16:17:27","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/li-lab\/wp-json\/wp\/v2\/posts\/392"}],"collection":[{"href":"https:\/\/health.uconn.edu\/li-lab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/health.uconn.edu\/li-lab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/li-lab\/wp-json\/wp\/v2\/users\/2764"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/li-lab\/wp-json\/wp\/v2\/comments?post=392"}],"version-history":[{"count":3,"href":"https:\/\/health.uconn.edu\/li-lab\/wp-json\/wp\/v2\/posts\/392\/revisions"}],"predecessor-version":[{"id":403,"href":"https:\/\/health.uconn.edu\/li-lab\/wp-json\/wp\/v2\/posts\/392\/revisions\/403"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/li-lab\/wp-json\/wp\/v2\/media?parent=392"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/health.uconn.edu\/li-lab\/wp-json\/wp\/v2\/categories?post=392"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/health.uconn.edu\/li-lab\/wp-json\/wp\/v2\/tags?post=392"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}