{"id":46,"date":"2017-06-23T16:20:28","date_gmt":"2017-06-23T20:20:28","guid":{"rendered":"https:\/\/health.uconn.edu\/levine-lab\/?page_id=46"},"modified":"2017-10-25T16:19:00","modified_gmt":"2017-10-25T20:19:00","slug":"research-projects","status":"publish","type":"page","link":"https:\/\/health.uconn.edu\/levine-lab\/research-projects\/","title":{"rendered":"Research Projects"},"content":{"rendered":"<div id=\"pl-46\"  class=\"panel-layout\" ><div id=\"pg-46-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-46-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-46-0-0-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"0\" ><div class=\"textwidget\"><h3>Induced pluripotent stem cell models of neurodevelopmental disease<\/h3>\n<p>We study forebrain neurons differentiated from patient-specific induced pluripotent stem cells to examine the cellular and synaptic pathophysiology in Angelman syndrome and dup15q autism.<\/p>\n<\/div><\/div><\/div><\/div><div id=\"pg-46-1\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-46-1-0\"  class=\"panel-grid-cell\" ><div id=\"panel-46-1-0-0\" class=\"so-panel widget widget_widget_sp_image widget_sp_image panel-first-child panel-last-child\" data-index=\"1\" ><a href=\"https:\/\/www.nature.com\/articles\/ncomms15038\" target=\"_self\" class=\"widget_sp_image-image-link\"><img loading=\"lazy\" decoding=\"async\" width=\"994\" height=\"833\" alt=\"NatComm paper\" class=\"attachment-full\" style=\"max-width: 100%;\" srcset=\"https:\/\/health.uconn.edu\/levine-lab\/wp-content\/uploads\/sites\/128\/2017\/06\/NatComm.jpg 994w, https:\/\/health.uconn.edu\/levine-lab\/wp-content\/uploads\/sites\/128\/2017\/06\/NatComm-300x251.jpg 300w, https:\/\/health.uconn.edu\/levine-lab\/wp-content\/uploads\/sites\/128\/2017\/06\/NatComm-768x644.jpg 768w\" sizes=\"(max-width: 994px) 100vw, 994px\" src=\"https:\/\/health.uconn.edu\/levine-lab\/wp-content\/uploads\/sites\/128\/2017\/06\/NatComm.jpg\" \/><\/a><div class=\"widget_sp_image-description\" ><p>Recent Nature Communications paper<\/p>\n<\/div><\/div><\/div><div id=\"pgc-46-1-1\"  class=\"panel-grid-cell\" ><div id=\"panel-46-1-1-0\" class=\"so-panel widget widget_widget_sp_image widget_sp_image panel-first-child panel-last-child\" data-index=\"2\" ><img loading=\"lazy\" decoding=\"async\" width=\"767\" height=\"569\" alt=\"ephys figure\" class=\"attachment-full\" style=\"max-width: 100%;\" src=\"https:\/\/health.uconn.edu\/levine-lab\/wp-content\/uploads\/sites\/128\/2017\/06\/img1E-e1499713767730.gif\" \/><\/div><\/div><\/div><div id=\"pg-46-2\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-46-2-0\"  class=\"panel-grid-cell\" ><div id=\"panel-46-2-0-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"3\" ><div class=\"textwidget\"><h3>\u00a0<\/h3>\n<h3 class=\"style9\"><span class=\"style2\">BDNF and endogenous cannabinoid interactions in the neocortex and hippocampus<\/span><\/h3>\n<\/div><\/div><\/div><\/div><div id=\"pg-46-3\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-46-3-0\"  class=\"panel-grid-cell\" ><div id=\"panel-46-3-0-0\" class=\"so-panel widget widget_widget_sp_image widget_sp_image panel-first-child panel-last-child\" data-index=\"4\" ><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"318\" alt=\"synapse pic\" class=\"attachment-full\" style=\"max-width: 100%;\" srcset=\"https:\/\/health.uconn.edu\/levine-lab\/wp-content\/uploads\/sites\/128\/2017\/06\/synapse-graph-abstract.png 400w, https:\/\/health.uconn.edu\/levine-lab\/wp-content\/uploads\/sites\/128\/2017\/06\/synapse-graph-abstract-300x239.png 300w\" sizes=\"(max-width: 400px) 100vw, 400px\" src=\"https:\/\/health.uconn.edu\/levine-lab\/wp-content\/uploads\/sites\/128\/2017\/06\/synapse-graph-abstract.png\" \/><div class=\"widget_sp_image-description\" ><p>BDNF modulates presynaptic release probability at cortical glutamatergic synapses via opposing pre- and postsynaptic effects. BDNF activates presynaptic trkB receptors to directly enhance release probability, while simultaneously triggering the postsynaptic release of endocannabinoids that act to decrease release via presynaptic CB1 receptors. <\/p>\n<\/div><\/div><\/div><div id=\"pgc-46-3-1\"  class=\"panel-grid-cell\" ><div id=\"panel-46-3-1-0\" class=\"so-panel widget widget_widget_sp_image widget_sp_image panel-first-child panel-last-child\" data-index=\"5\" ><img loading=\"lazy\" decoding=\"async\" width=\"741\" height=\"696\" alt=\"neuron pics\" class=\"attachment-full\" style=\"max-width: 100%;\" srcset=\"https:\/\/health.uconn.edu\/levine-lab\/wp-content\/uploads\/sites\/128\/2017\/06\/img18.jpg 741w, https:\/\/health.uconn.edu\/levine-lab\/wp-content\/uploads\/sites\/128\/2017\/06\/img18-300x282.jpg 300w\" sizes=\"(max-width: 741px) 100vw, 741px\" src=\"https:\/\/health.uconn.edu\/levine-lab\/wp-content\/uploads\/sites\/128\/2017\/06\/img18.jpg\" \/><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Induced pluripotent stem cell models of neurodevelopmental diseaseWe study forebrain neurons differentiated from patient-specific induced pluripotent stem cells to examine the cellular and synaptic pathophysiology in Angelman syndrome and dup15q autism.<\/p>\n","protected":false},"author":281,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-30 09:39:43","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/levine-lab\/wp-json\/wp\/v2\/pages\/46"}],"collection":[{"href":"https:\/\/health.uconn.edu\/levine-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/health.uconn.edu\/levine-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/levine-lab\/wp-json\/wp\/v2\/users\/281"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/levine-lab\/wp-json\/wp\/v2\/comments?post=46"}],"version-history":[{"count":9,"href":"https:\/\/health.uconn.edu\/levine-lab\/wp-json\/wp\/v2\/pages\/46\/revisions"}],"predecessor-version":[{"id":190,"href":"https:\/\/health.uconn.edu\/levine-lab\/wp-json\/wp\/v2\/pages\/46\/revisions\/190"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/levine-lab\/wp-json\/wp\/v2\/media?parent=46"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}