Research

Publications

Konstorum, A., Lowengrub, J.S. Activation of the HGF/c-Met axis in the tumor microenvironment: a multispecies model (submitted).

Borje, G., Esser E., Konstorum, A. Sproutogram: a method for estimating in vitro Fibrin Gel Bead Sprouting Angiogenesis (FGBSA) Statistics (submitted).

Yan, H.*, Konstorum, A.*, Lowengrub, J.S. (2017) Three-dimensional spatiotemporal modeling of colon cancer organoids reveals that multimodal control of stem cell self-renewal is a critical determinant of size and shape in early stages of tumor growth, Bulletin of Mathematical Biology. doi:10.1007/s11538-017-0294-1 (.)

Konstorum, A., Vella, A.T., Adler, A.J., Laubenbacher, R.C. (2017) Addressing current challenges in cancer immunotherapy with mathematical and computational modelingJournal of the Royal Society Interface, 14(131): 20170150. doi:10.1098/rsif.2017.0150 (.)

Konstorum, A., Hillen, T., Lowengrub, J.S. (2016) Feedback regulation in a cancer stem cell model can cause an Allee effect, Bulletin of Mathematical Biology, 78(4), 754-785.  doi:10.1007/s11538-016-0161-5 (.)

Konstorum, A., Sprowl, S.A., Lander, A.D., Waterman, M.L., Lowengrub, J.S. (2013) Predicting mechanism of biphasic growth factor action on tumor growth using a multi-species model with feedback control, J. Coupled Syst. Multiscale Dyn, 1(4), 459-467. doi:10.1166/jcsmd.2013.1028 (.)

Lim M., Hou A., Congdon N., Chua J. (2013) Feature Identification for Colon Tumor Classification, SIAM Undergraduate Journal Online, 6, 264-274. (Served as faculty advisor). doi:10.1137/13S012212 (.)

Konstorum, A., Sprowl, S.A., Lander, A.D., Waterman, M.L., Lowengrub, J.S. (2013) Elaboration of a multispecies model of solid tumor growth with tumor-host interactions, Proc. 3rd Int Conf. Appl. Nonlinear Dynamics, Seattle, WA Springer Verlag p.295-303doi:10.1007/978-3-319-02925-2_26 (.)

Zhou, B., Tieu, K.H., Konstorum, A., Duong, T., Wells, WM, Brown, G.G., Stern, H., and Shahbaba, B. (2013) A hierarchical modeling approach to data analysis and study design in a multi-site experimental fMRI study, Psychometrika, 78(12), 260-278. doi:10.1007/s11336-012-9298-9 (.)

Wang, T.T., Tavera-Mendoza, L., Laperriere, D., Nagai, Y., Burton MacLeod, N., Libby, E., Zhang, R., Bourdeau, V., Konstorum, A., Lallemant, B., Mader, S. and White, J.H. (2005) Large-scale in silico and microarray-based genomic screening of 1,25-dihydroxyvitamin D3 target genes, Mol. Endocrinol. 19, 2685-95. doi:10.1210/me.2005-0106  (.)

Theses

Konstorum, A (2015) Mathematical modeling of tumor-microenvironment dynamics, Ph.D. Thesis. University of California, Irvine. Permalink (.)

Konstorum, A. (2010) Computational determination of SNP-induced splicing deregulation in the human genome, M.S. Thesis. University of California, Los Angeles. (.)

Talks

A stochastic algebraic model of synergistic T cell activation by pharmaceutical agonists (7/2016) SIAM Conference on the Life Sciences, Boston, MA

A multi-level model of synergistic T cell activation (5/2016) Biology and Medicine Through Mathematics (BAMM!) Conference, Richmond, VA (abstract)

Feedback regulation in a cancer stem cell model can cause an Allee effect (12/2015); Present Challenges of Mathematics in Oncology and Cancer, Centre International de Rencontres Mathématiques (CIRM), Marseille, France

Mathematics of Multistationarity (03/2015); Whittier College, Whittier, CA; Cal State Fullerton, Fullerton, CA (.)

Quantification of tumor-environment interactions (05/2014); Center for Complex Biological Systems Center Retreat, Pasadena, CA

A multispecies mathematical model to predict non-monotonic effects of HGF on tumor spheroid growth (08/2013); Applied Mathematics, Modeling, and Computational Science (AMMCS) Conference, Waterloo, Canada

Posters

Comparative Analysis of Linear and Nonlinear Dimension Reduction Techniques on Mass Cytometry Data (09/2016); Mathematical Biosciences Institute (MBI) Emphasis Workshop ‘Topological, Geometric, and Statistical Techniques in Biological Data Analysis’, Columbus, Ohio.

Incorporation of the HGF/c-Met axis into a multispecies model of solid tumor growth (06/2015); Society for Mathematical Biology Annual Meeting, Atlanta, Georgia.

Prediction of biphasic mitogenic activity by HGF, a cancer-associated stroma-derived growth factor, using a multispecies continuum model (08/2014); SIAM Conference on the Life Sciences, Charlotte, North Carolina (.)

Predicting nonlinearity of tumor spheroid growth in HGF media: a data-driven multispecies continuum model (06/2013) Institute of Physics (IOP) Conference: Physics of Emergent Behaviour, Brighton, UK

Towards an experimentally-calibrated multispecies continuum model of tumor growth in microenvironment (08/2012) International Conference on Theory and Applications in Nonlinear Dynamics, Seattle, WA.

The microenvironment in tumor growth and Wnt dynamics: a multispecies continuum model (06/2011); Wnt 2011 Conference, Los Angeles, CA