Research

Publications

 

Konstorum, A., Lowengrub, J.S. (2018) Activation of the HGF/c-Met axis in the tumor microenvironment: a multispecies model, Journal of Theoretical Biology, 439: 86-99. doi: org/10.1016/j.jtbi.2017.11.025 (.)

Yan, H.*, Konstorum, A.*, Lowengrub, J.S. (2017) Three-dimensional spatiotemporal modeling of colon cancer organoids reveals that multimodal control of stem cell self-renewal is a critical determinant of size and shape in early stages of tumor growth, Bulletin of Mathematical Biologydoi:10.1007/s11538-017-0294-1 (.) (*authors contributed equally to the manuscript).

Konstorum, A., Vella, A.T., Adler, A.J., Laubenbacher, R.C. (2017) Addressing current challenges in cancer immunotherapy with mathematical and computational modeling, Journal of the Royal Society Interface, 14(131): 20170150. doi:10.1098/rsif.2017.0150 (.)

Konstorum, A., Hillen, T., Lowengrub, J.S. (2016) Feedback regulation in a cancer stem cell model can cause an Allee effect, Bulletin of Mathematical Biology78(4), 754-785.  doi:10.1007/s11538-016-0161-5 (.)

Konstorum, A., Sprowl, S.A., Lander, A.D., Waterman, M.L., Lowengrub, J.S. (2013) Predicting mechanism of biphasic growth factor action on tumor growth using a multi-species model with feedback control, J. Coupled Syst. Multiscale Dyn, 1(4), 459-467. doi:10.1166/jcsmd.2013.1028 (.)

Lim M., Hou A., Congdon N., Chua J. (2013) Feature Identification for Colon Tumor Classification, SIAM Undergraduate Journal Online, 6, 264-274. (Served as faculty advisor). doi:10.1137/13S012212 (.)

Konstorum, A., Sprowl, S.A., Lander, A.D., Waterman, M.L., Lowengrub, J.S. (2013) Elaboration of a multispecies model of solid tumor growth with tumor-host interactions, Proc. 3rd Int Conf. Appl. Nonlinear Dynamics, Seattle, WA Springer Verlag p.295-303doi:10.1007/978-3-319-02925-2_26 (.)

Zhou, B., Tieu, K.H., Konstorum, A., Duong, T., Wells, WM, Brown, G.G., Stern, H., and Shahbaba, B. (2013) A hierarchical modeling approach to data analysis and study design in a multi-site experimental fMRI study, Psychometrika, 78(12), 260-278. doi:10.1007/s11336-012-9298-9 (.)

Wang, T.T., Tavera-Mendoza, L., Laperriere, D., Nagai, Y., Burton MacLeod, N., Libby, E., Zhang, R., Bourdeau, V., Konstorum, A., Lallemant, B., Mader, S. and White, J.H. (2005) Large-scale in silico and microarray-based genomic screening of 1,25-dihydroxyvitamin D3 target genes, Mol. Endocrinol. 19, 2685-95. doi:10.1210/me.2005-0106  (.)

Theses

Konstorum, A (2015) Mathematical modeling of tumor-microenvironment dynamics, Ph.D. Thesis. University of California, Irvine. Permalink (.)

Konstorum, A. (2010) Computational determination of SNP-induced splicing deregulation in the human genome, M.S. Thesis. University of California, Los Angeles. (.)

Talks

Synergy through nonlinearity: a model for supereffector T cell generation by immunotherapy (7/2017); Society for Mathematical Biology Annual Meeting, Salt Lake City, Utah

A stochastic algebraic model of synergistic T cell activation by pharmaceutical agonists (7/2016); SIAM Conference on the Life Sciences, Boston, MA

A multi-level model of synergistic T cell activation (5/2016); Biology and Medicine Through Mathematics (BAMM!) Conference, Richmond, VA (abstract)

Feedback regulation in a cancer stem cell model can cause an Allee effect (12/2015); Present Challenges of Mathematics in Oncology and Cancer, Centre International de Rencontres Mathématiques (CIRM), Marseille, France

Mathematics of Multistationarity (03/2015); Whittier College, Whittier, CA; Cal State Fullerton, Fullerton, CA (.)

Quantification of tumor-environment interactions (05/2014); Center for Complex Biological Systems Center Retreat, Pasadena, CA

A multispecies mathematical model to predict non-monotonic effects of HGF on tumor spheroid growth (08/2013); Applied Mathematics, Modeling, and Computational Science (AMMCS) Conference, Waterloo, Canada

Posters

Comparative Analysis of Linear and Nonlinear Dimension Reduction Techniques on Mass Cytometry Data (09/2016); Mathematical Biosciences Institute (MBI) Emphasis Workshop ‘Topological, Geometric, and Statistical Techniques in Biological Data Analysis’, Columbus, Ohio.

Incorporation of the HGF/c-Met axis into a multispecies model of solid tumor growth (06/2015); Society for Mathematical Biology Annual Meeting, Atlanta, Georgia.

Prediction of biphasic mitogenic activity by HGF, a cancer-associated stroma-derived growth factor, using a multispecies continuum model (08/2014); SIAM Conference on the Life Sciences, Charlotte, North Carolina (.)

Predicting nonlinearity of tumor spheroid growth in HGF media: a data-driven multispecies continuum model (06/2013); Institute of Physics (IOP) Conference: Physics of Emergent Behaviour, Brighton, UK

Towards an experimentally-calibrated multispecies continuum model of tumor growth in microenvironment (08/2012); International Conference on Theory and Applications in Nonlinear Dynamics, Seattle, WA.

The microenvironment in tumor growth and Wnt dynamics: a multispecies continuum model (06/2011); Wnt 2011 Conference, Los Angeles, CA