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Welcome

I'm an adjunct associate at the Center for Quantitative Medicine at UConn Health.  My work focuses on multi-omics data analysis and dynamic modeling of biological processes.

Research at CQM

(1) Development of logical and continuous models of

  • Iron-oncogene interactions in ovarian cancer (in collaboration with the Torti group in the Department of Molecular Biology and Biophysics at UConn Health).
  • Combination cancer immunotherapy (in collaboration with the Vella and Adler groups in the Department of Immunology at UConn Health).

(2) Development and utilization of dimension reduction, statistical learning, and topological methods for analysis of 'big data' in biology stemming from high-throughput technologies.

News

(08/20) Our latest research on using tensor decomposition for multi-omics data will be presented via a virtual poster at the Johns Hopkins University Applied Physics Laboratory (APL) National Health Symposium on September 14-15, 2020.  Please register and 'stop by' if you are interested!

(03/20) Systems biology of ferroptosis: A modeling approach now published in the Journal of Theoretical Biology! Code is available.

(09/19) The schedule for the AMS Special Session on Computational Biomedicine at JMM 2020 is now available! I'll be giving a talk on the fruits of the long-standing collaborative effort with the Torti lab, titled 'Identifying critical pathways for ferroptosis using a systems approach' (abstract).

(07/19) 'A mathematical model of combined CD8 T cell costimulation by 4-1BB (CD137) and OX40 (CD134) receptors', collaborative work with Anthony Vella and Adam Adler in the Department of Immunology at UConn Health now published in Scientific Reports.

(07/19) 'Steroyl-CoA Desaturase 1 (SCD1) protects ovarian cancer cells from ferroptotic cell death', collaborative work with the Torti lab in the Department of Molecular Biology and Biophysics at UConn Health now published in Cancer Research.

(05/19) Our OMICS manuscript on the link between iron and fatty acid synthesis in cancer is among the top-20 most-read OMICS articles!

(04/19) 'Neoantigens retention in patient derived xenograft models mediates autologous T cells activation in ovarian cancer' now published! Stemming from a collaboration with the Battaglia lab at Roswell Park Cancer Institute.

Contact Information

konstorum@uchc.edu
Address: 263 Farmington Avenue
Farmington, CT 06030