Welcome

I'm an Adjunct Associate at the Center for Quantitative Medicine at UConn Health.  I was previously a postdoctoral fellow, and continue to collaborate and work on the projects outlined below.

Research at CQM

(1) Development of logical and continuous models of

  • Combination cancer immunotherapy (in collaboration with the Vella and Adler groups in the Department of Immunology at UConn Health).
  • Iron-oncogene interactions in ovarian cancer (in collaboration with the Torti group in the Department of Molecular Biology and Biophysics at UConn Health).

(2) Development and utilization of dimension reduction, statistical learning, and topological methods for analysis of 'big data' in biology stemming from high-throughput technologies.

News

(05/19) Our OMICS manuscript on the link between iron and fatty acid synthesis in cancer is amongst the top-20 most-read OMICS articles!

(04/19) 'Neoantigens retention in patient derived xenograft models mediates autologous T cells activation in ovarian cancer' now published!  Stemming from a collaboration with the Battaglia lab at Roswell Park Cancer Institute.

(09/18) Our work on the link between iron and fatty acid synthesis in cancer has been featured in UConn Today!  Read all about it here!

(07/18) 'A systems biology approach to understanding the pathophysiology of high grade serous ovarian cancer: focus on iron and fatty acid metabolism' with co-authors Miranda Lynch, Suzy Torti, Frank Torti, and Reinhard Laubenbacher published in OMICS: A Journal of Integrative Biology.

(04/18) 'Contribution of three-dimensional architecture and tumor-associated fibroblasts to hepcidin regulation in breast cancer' with co-authors Nicole Blanchette-Farra et al. published in Oncogene.

(12/17) 'Activation of the HGF/c-Met axis in the tumor microenvironment: A multispecies model' with co-author John Lowengrub published in the Journal of Theoretical Biology.

(7/17)  'Three-Dimensional Spatiotemporal Modeling of Colon Cancer Organoids Reveals that Multimodal Control of Stem Cell Self-Renewal is a Critical Determinant of Size and Shape in Early Stages of Tumor Growth', with co-authors Huaming Yan and John Lowengrub published in the Bulletin of Mathematical Biology.

Contact Information

konstorum@uchc.edu
Address: 263 Farmington Avenue
Farmington, CT 06030