Welcome

I'm an adjunct associate at the Center for Quantitative Medicine at UConn Health. I was previously a postdoctoral fellow, and continue to collaborate and work on the projects outlined below.

Research at CQM

(1) Development of logical and continuous models of

  • Combination cancer immunotherapy (in collaboration with the Vella and Adler groups in the Department of Immunology at UConn Health).
  • Iron-oncogene interactions in ovarian cancer (in collaboration with the Torti group in the Department of Molecular Biology and Biophysics at UConn Health).

(2) Development and utilization of dimension reduction, statistical learning, and topological methods for analysis of 'big data' in biology stemming from high-throughput technologies.

News

(09/19) The schedule for the AMS Special Session on Computational Biomedicine at JMM 2020 is now available!  I'll be giving a talk on the fruits of the long-standing collaborative effort with the Torti lab, titled 'Identifying critical pathways for ferroptosis using a systems approach' (abstract).

(07/19) 'A mathematical model of combined CD8 T cell costimulation by 4-1BB (CD137) and OX40 (CD134) receptors', collaborative work with Anthony Vella and Adam Adler in the Department of Immunology at UConn Health now published in Scientific Reports.

(07/19) 'Steroyl-CoA Desaturase 1 (SCD1) protects ovarian cancer cells from ferroptotic cell death', collaborative work with the Torti lab in the Department of Molecular Biology and Biophysics at UConn Health now published in Cancer Research.

(05/19) Our OMICS manuscript on the link between iron and fatty acid synthesis in cancer is amongst the top-20 most-read OMICS articles!

(04/19) 'Neoantigens retention in patient derived xenograft models mediates autologous T cells activation in ovarian cancer' now published!  Stemming from a collaboration with the Battaglia lab at Roswell Park Cancer Institute.

(09/18) Our work on the link between iron and fatty acid synthesis in cancer has been featured in UConn Today!  Read all about it here!

(07/18) 'A systems biology approach to understanding the pathophysiology of high grade serous ovarian cancer: focus on iron and fatty acid metabolism' with co-authors Miranda Lynch, Suzy Torti, Frank Torti, and Reinhard Laubenbacher published in OMICS: A Journal of Integrative Biology.

Contact Information

konstorum@uchc.edu
Address: 263 Farmington Avenue
Farmington, CT 06030