{"id":796,"date":"2016-02-23T10:47:01","date_gmt":"2016-02-23T15:47:01","guid":{"rendered":"http:\/\/immunology.uchc.edu\/?p=796"},"modified":"2016-02-23T10:47:01","modified_gmt":"2016-02-23T15:47:01","slug":"key-publication-in-pnas-from-the-laboratory-of-dr-kamal-khanna","status":"publish","type":"post","link":"https:\/\/health.uconn.edu\/immunology\/2016\/02\/23\/key-publication-in-pnas-from-the-laboratory-of-dr-kamal-khanna\/","title":{"rendered":"Key Publication in PNAS from the Laboratory of Dr. Kamal Khanna"},"content":{"rendered":"<figure id=\"attachment_795\" aria-describedby=\"caption-attachment-795\" style=\"width: 350px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-795\" src=\"https:\/\/health.uconn.edu\/immunology\/wp-content\/uploads\/sites\/67\/2016\/02\/spotlight_khanna.jpg\" alt=\"Dr. Kamal Khanna\" width=\"350\" height=\"200\" srcset=\"https:\/\/health.uconn.edu\/immunology\/wp-content\/uploads\/sites\/67\/2016\/02\/spotlight_khanna.jpg 350w, https:\/\/health.uconn.edu\/immunology\/wp-content\/uploads\/sites\/67\/2016\/02\/spotlight_khanna-300x171.jpg 300w\" sizes=\"(max-width: 350px) 100vw, 350px\" \/><figcaption id=\"caption-attachment-795\" class=\"wp-caption-text\"><a href=\"http:\/\/facultydirectory.uchc.edu\/profile?profileId=Khanna-Kamal\">Dr. Kamal Khanna&#8217;s<\/a> lab and research on T cell migration during a viral infection has earned a key publication in the <a href=\"http:\/\/www.pnas.org\/content\/early\/2016\/02\/08\/1516485113.abstract\">Proceedings of the National Academy of Sciences (PNAS)<\/a>. This study lays the foundation for developing better therapeutic strategies against autoimmune and infectious diseases that target T cell intrinsic S1P-S1PR axis.\u00a0<\/figcaption><\/figure>\n<p>The T cells have to get to the tissue where there is an infection in order to help eradicate the invading virus or bacteria.\u00a0 Thus, the control of a microbial infection by effector T cells is intrinsically linked to their migration. However, little is known about the mechanisms that control effector T cell egress after infection. We need to understand this important biological process in order to develop better vaccines and immuno-therapeutic strategies to treat infectious diseases and cancers.\u00a0 In the current study we investigated the role of an important protein called sphingosine-1-phosphate-receptor-1 (S1PR1) in regulating T cell migration during a viral infection.\u00a0 S1PR is currently being targeted for therapy against several autoimmune diseases such as multiple sclerosis (MS). In our current study we used multi-photon microscopy to visualized in real time pathogen-specific, effector T cell migration in live animals within, and from, the draining lymph node (dLN).\u00a0 We utilized a novel inducible mouse model with temporally disrupted S1PR1 gene specifically in endogenous effector T cells.\u00a0 We demonstrate that S1PR1 signaling is the most critical mechanism that regulates effector T cell egress from the dLN following a local infection, and even in the absence of retention signals, T cell intrinsic S1PR1 signaling is the dominant mechanism that regulates transendothelial migration and effector T cell emigration from the dLN and thus, we conclude that S1PR1 is the master regulator of effector T cell egress after infection.\u00a0 Thus, our study lays the foundation for developing better therapeutic strategies against autoimmune and infectious diseases that target T cell intrinsic S1P-S1PR axis.<\/p>\n<p>For more information on this paper, please go to <a href=\"http:\/\/www.pnas.org\/content\/early\/2016\/02\/08\/1516485113.abstract\">http:\/\/www.pnas.org\/content\/early\/2016\/02\/08\/1516485113.abstract<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The T cells have to get to the tissue where there is an infection in order to help eradicate the invading virus or bacteria.\u00a0 Thus, the control of a microbial infection by effector T cells is intrinsically linked to their migration. However, little is known about the mechanisms that control effector T cell egress after [&hellip;]<\/p>\n","protected":false},"author":39,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"wds_primary_category":0,"footnotes":""},"categories":[1],"tags":[],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-21 02:43:37","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/posts\/796"}],"collection":[{"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/users\/39"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/comments?post=796"}],"version-history":[{"count":0,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/posts\/796\/revisions"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/media?parent=796"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/categories?post=796"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/tags?post=796"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}