{"id":3467,"date":"2025-02-01T07:00:51","date_gmt":"2025-02-01T12:00:51","guid":{"rendered":"https:\/\/health.uconn.edu\/immunology\/2024\/11\/25\/dr-wang-and-dr-harrisons-paper-published-in-nature-immunology-2\/"},"modified":"2025-02-18T11:16:58","modified_gmt":"2025-02-18T16:16:58","slug":"paper-in-nature-immunology-dr-srivastava-dr-singhaviranon","status":"publish","type":"post","link":"https:\/\/health.uconn.edu\/immunology\/2025\/02\/01\/paper-in-nature-immunology-dr-srivastava-dr-singhaviranon\/","title":{"rendered":"Paper in Nature Immunology-Dr. Srivastava &amp; Dr. Singhaviranon"},"content":{"rendered":"<div id=\"pl-3467\"  class=\"panel-layout\" ><div id=\"pg-3467-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-3467-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-3467-0-0-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"0\" ><div class=\"textwidget\"><p>Dr. Summit Singhaviranon and Dr. Pramod Srivastava's lab published a paper, entitled <a href=\"https:\/\/www.nature.com\/articles\/s41590-024-02044-z\">Low-avidity T cells drive endogenous tumor immunity in mice and humans<\/a>\u00a0in<em>\u00a0Nature Immunology<\/em>, which demonstrates the superior anti-tumor activity of T cells with weak binding to cancer cells over T cells with strong binding to cancer cells in both mice and humans. Their paper both provides a fundamental mechanistic rationale for this finding and proposes a viable approach to translate these findings to patient care.\u00a0 Their work \u00a0challenges the existing paradigm that is focused on maximizing T cell binding to cancer cells and has the potential to improve cancer patient outcomes in numerous ways.<\/p>\n<\/div><\/div><\/div><div id=\"pgc-3467-0-1\"  class=\"panel-grid-cell\" ><div id=\"panel-3467-0-1-0\" class=\"so-panel widget widget_widget_sp_image widget_sp_image panel-first-child panel-last-child\" data-index=\"1\" ><h3 class=\"widget-title\"> <\/h3><img loading=\"lazy\" decoding=\"async\" width=\"350\" height=\"200\" alt=\"Dr. Srivastava &amp; Summit Singhaviranon\" class=\"attachment-full\" style=\"max-width: 100%;\" src=\"https:\/\/health.uconn.edu\/immunology\/wp-content\/uploads\/sites\/67\/2024\/11\/Untitled-1-1.gif\" \/><div class=\"widget_sp_image-description\" ><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Dr. Summit Singhaviranon and Dr. Pramod Srivastava&#8217;s lab published a paper, entitled Low-avidity T cells drive endogenous tumor immunity in mice and humans\u00a0in\u00a0Nature Immunology, which demonstrates the superior anti-tumor activity of T cells with weak binding to cancer cells over T cells with strong binding to cancer cells in both mice and humans. Their paper [&hellip;]<\/p>\n","protected":false},"author":1662,"featured_media":3462,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"wds_primary_category":0,"footnotes":""},"categories":[1],"tags":[],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-28 13:16:54","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/posts\/3467"}],"collection":[{"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/users\/1662"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/comments?post=3467"}],"version-history":[{"count":2,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/posts\/3467\/revisions"}],"predecessor-version":[{"id":3468,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/posts\/3467\/revisions\/3468"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/media\/3462"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/media?parent=3467"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/categories?post=3467"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/tags?post=3467"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}