{"id":1995,"date":"2021-05-04T11:32:11","date_gmt":"2021-05-04T15:32:11","guid":{"rendered":"https:\/\/health.uconn.edu\/immunology\/?p=1995"},"modified":"2021-05-05T08:14:10","modified_gmt":"2021-05-05T12:14:10","slug":"jianbin-ruan-paper-accepted-for-publication-in-nature","status":"publish","type":"post","link":"https:\/\/health.uconn.edu\/immunology\/2021\/05\/04\/jianbin-ruan-paper-accepted-for-publication-in-nature\/","title":{"rendered":"Jianbin Ruan Paper Accepted for Publication in Nature"},"content":{"rendered":"<div id=\"pl-1995\"  class=\"panel-layout\" ><div id=\"pg-1995-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-1995-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-1995-0-0-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"0\" ><div class=\"textwidget\"><p>In this paper, <em>Gasdermin D pore structure reveals preferential release of mature interleukin-1<\/em>, Ruan and collaborators reported the cryo-EM structure of human Gasdermin D (GSDMD) pore, an inflammatory cell death executioner molecule, at 3.9 \u00c5 resolution. GSDMD pore exhibits large differences in symmetry and dimensions from the previously reported GSDMA3, a mouse homolog. Beyond the structure of the human GSDMD pore, the paper also demonstrated that GSDMD forms an acidic shield that directly regulates IL-1 secretion via a charge-based mechanism. This discovery will facilitate future investigation into the GSDMD secretome and, to our knowledge, first proposes how large transmembrane pores may achieve substrate selectivity. This study is a collaborative effort between Dr. Ruan\u2019s lab and the laboratories of Wu and Lieberman at Harvard Medical School, the laboratory of Greka at Broad Institute of MIT, and the laboratory of Jacobson at the University of California San Francisco.<\/p>\n<\/div><\/div><\/div><div id=\"pgc-1995-0-1\"  class=\"panel-grid-cell\" ><div id=\"panel-1995-0-1-0\" class=\"so-panel widget widget_widget_sp_image widget_sp_image panel-first-child panel-last-child\" data-index=\"1\" ><img loading=\"lazy\" decoding=\"async\" width=\"350\" height=\"200\" alt=\"Jianbin Ruan, Ph.D.\" class=\"attachment-full\" style=\"max-width: 100%;\" srcset=\"https:\/\/health.uconn.edu\/immunology\/wp-content\/uploads\/sites\/67\/2019\/09\/ruan_jianbin_20190806_krwallace_5529_350x200.jpg 350w, https:\/\/health.uconn.edu\/immunology\/wp-content\/uploads\/sites\/67\/2019\/09\/ruan_jianbin_20190806_krwallace_5529_350x200-300x171.jpg 300w\" sizes=\"(max-width: 350px) 100vw, 350px\" src=\"https:\/\/health.uconn.edu\/immunology\/wp-content\/uploads\/sites\/67\/2019\/09\/ruan_jianbin_20190806_krwallace_5529_350x200.jpg\" \/><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>In this paper, Gasdermin D pore structure reveals preferential release of mature interleukin-1, Ruan and collaborators reported the cryo-EM structure of human Gasdermin D (GSDMD) pore, an inflammatory cell death executioner molecule, at 3.9 \u00c5 resolution. GSDMD pore exhibits large differences in symmetry and dimensions from the previously reported GSDMA3, a mouse homolog. Beyond the [&hellip;]<\/p>\n","protected":false},"author":38,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"wds_primary_category":0,"footnotes":""},"categories":[1],"tags":[],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-26 07:04:48","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/posts\/1995"}],"collection":[{"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/users\/38"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/comments?post=1995"}],"version-history":[{"count":3,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/posts\/1995\/revisions"}],"predecessor-version":[{"id":1999,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/posts\/1995\/revisions\/1999"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/media?parent=1995"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/categories?post=1995"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/tags?post=1995"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}