{"id":1982,"date":"2021-01-22T12:03:00","date_gmt":"2021-01-22T17:03:00","guid":{"rendered":"https:\/\/health.uconn.edu\/immunology\/?p=1982"},"modified":"2021-01-22T12:04:24","modified_gmt":"2021-01-22T17:04:24","slug":"vijay-rathinam-paper-accepted-in-nature-immunology","status":"publish","type":"post","link":"https:\/\/health.uconn.edu\/immunology\/2021\/01\/22\/vijay-rathinam-paper-accepted-in-nature-immunology\/","title":{"rendered":"Vijay Rathinam Paper Accepted in Nature Immunology"},"content":{"rendered":"<div id=\"pl-1982\"  class=\"panel-layout\" ><div id=\"pg-1982-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-1982-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-1982-0-0-0\" class=\"so-panel widget widget_black-studio-tinymce widget_black_studio_tinymce panel-first-child panel-last-child\" data-index=\"0\" ><div class=\"textwidget\"><p>In an article entitled \u201cIntracellular immune sensing promotes inflammation via gasdermin D-driven release of a lectin alarmin\u201d published in Nature Immunology, Dr. Vijay Rathinam\u2019s lab discovered a sugar-binding protein called galectin-1 as bona fide danger molecule that is released during excessive cell death promoting \"cytokine storm\" and inflammation during sepsis. The findings from the study advances our understanding of pathogenic mechanisms in sepsis, the leading cause of death for patients in the intensive care unit with 270,000 deaths annually in the US. and lay the foundation for identifying novel biomarkers and therapeutic targets in sepsis. This study was led by Dr. Ashley Russo, a previous graduate student in the Rathinam lab and involved key collaborations with the laboratories of Vella, Menoret, Zhou, Ruan, and Vanaja in the Department of Immunology as well as additional labs in University of Florida, Jena University Hospital, Germany and the Experimental Medicine and Biology Institute, University of Buenos Aires, Argentina.<\/p>\n<\/div><\/div><\/div><div id=\"pgc-1982-0-1\"  class=\"panel-grid-cell\" ><div id=\"panel-1982-0-1-0\" class=\"so-panel widget widget_widget_sp_image widget_sp_image panel-first-child panel-last-child\" data-index=\"1\" ><img loading=\"lazy\" decoding=\"async\" width=\"350\" height=\"200\" alt=\"Dr. Vijay Rathinam standing next to Ashley Russo\" class=\"attachment-full\" style=\"max-width: 100%;\" srcset=\"https:\/\/health.uconn.edu\/immunology\/wp-content\/uploads\/sites\/67\/2017\/07\/ashley_russo_research_day_2017_350x200.jpg 350w, https:\/\/health.uconn.edu\/immunology\/wp-content\/uploads\/sites\/67\/2017\/07\/ashley_russo_research_day_2017_350x200-300x171.jpg 300w\" sizes=\"(max-width: 350px) 100vw, 350px\" src=\"https:\/\/health.uconn.edu\/immunology\/wp-content\/uploads\/sites\/67\/2017\/07\/ashley_russo_research_day_2017_350x200.jpg\" \/><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>In an article entitled \u201cIntracellular immune sensing promotes inflammation via gasdermin D-driven release of a lectin alarmin\u201d published in Nature Immunology, Dr. Vijay Rathinam\u2019s lab discovered a sugar-binding protein called galectin-1 as bona fide danger molecule that is released during excessive cell death promoting &#8220;cytokine storm&#8221; and inflammation during sepsis. The findings from the study [&hellip;]<\/p>\n","protected":false},"author":38,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"wds_primary_category":0,"footnotes":""},"categories":[1],"tags":[],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-08 16:37:40","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/posts\/1982"}],"collection":[{"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/users\/38"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/comments?post=1982"}],"version-history":[{"count":3,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/posts\/1982\/revisions"}],"predecessor-version":[{"id":1985,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/posts\/1982\/revisions\/1985"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/media?parent=1982"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/categories?post=1982"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/health.uconn.edu\/immunology\/wp-json\/wp\/v2\/tags?post=1982"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}