{"id":10,"date":"2017-05-23T15:00:39","date_gmt":"2017-05-23T19:00:39","guid":{"rendered":"https:\/\/health.uconn.edu\/hoch-lab\/?page_id=10"},"modified":"2019-02-01T13:18:06","modified_gmt":"2019-02-01T18:18:06","slug":"research","status":"publish","type":"page","link":"https:\/\/health.uconn.edu\/hoch-lab\/research\/","title":{"rendered":"Research"},"content":{"rendered":"

\"NMR<\/p>\n<\/div><\/div><\/div><\/div>

NMR Data Acquisition and Processing<\/h3>
    \n
  • Rapid multidimensional NMR using non-uniform sampling<\/li>\n
  • Non-Fourier spectral analysis, especially maximum entropy reconstruction<\/li>\n<\/ul>\n

    Rowland NMR Toolkit Collaborators<\/h4>\n
      \n
    • Alan Stern (Rowland Institute at Harvard)<\/li>\n
    • Gerhard Wagner (Harvard Medical School)<\/li>\n
    • Mehdi Mobli (University of Queensland)<\/li>\n
    • Mark Maciejewski (UConn Health)<\/li>\n
    • Michael Gryk (UConn Health)<\/li>\n
    • Adam Schuyler (UConn Health)<\/li>\n
    • Jay Vyas (UConn Health)<\/li>\n
    • Jonathan Helmus (UConn Health)<\/li>\n
    • Matthew Fenwick (UConn Health)<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div>

      \"Protein<\/p>\n<\/div><\/div><\/div><\/div>

      Protein Structure Refinement<\/h3>
      \n
        \n
      • Coarse-grained modeling<\/li>\n
      • MoSART: Molecular Structure Analysis and Refinement Tool<\/li>\n<\/ul>\n<\/div>\n

        Collaborator:<\/strong><\/p>\n

          \n
        • Alan Stern (Rowland Institute at Harvard)<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div>

          \"\"<\/p>\n<\/div><\/div><\/div><\/div>

          Prolactin: Structure, Dynamics, Stability, and Function<\/h3>
            \n
          • Promotes lactation during pregnancy; highly angiogenic, mytogenic for T cells<\/li>\n
          • Implicated in some breast cancers<\/li>\n
          • NMR relaxation studies of allosteric binding<\/li>\n<\/ul>\n

            Collaborators:<\/strong><\/p>\n

              \n
            • Janus Vang (UConn Health)<\/li>\n
            • Birthe Kragelund (University of Copenhagen)<\/li>\n
            • Dmitry M. Korzhnev (UConn Health)<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div>

              \"PfPMT:<\/p>\n<\/div><\/div><\/div><\/div>

              PfPMT: Structure, Dynamics, Stability, and Function<\/h3>
                \n
              • Essential methyltransferase from Plasmodium palcifarum, the causative agent of malaria<\/li>\n
              • Identify inhibitors<\/li>\n<\/ul>\n

                Collaborators:<\/strong><\/p>\n

                  \n
                • Choukri Ben Mamoun (Yale Medical School)<\/li>\n
                • Iulian Rujan (UConn Health)<\/li>\n
                • Irina Bezsonova (UConn Health)<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div>

                  \"Osmometry<\/p>\n<\/div><\/div><\/div><\/div>

                  Osmometry for Probing Water-Biomolecule Interactions<\/h3>
                    \n
                  • 2nd virial coefficients, hydrophobic effect, preferential interactions<\/li>\n
                  • Design and construction of a high precision, high dynamic range instrument<\/li>\n<\/ul>\n

                    Collaborators:<\/strong><\/p>\n

                      \n
                    • Alan Stern (Rowland Institute at Harvard)<\/li>\n
                    • Winfred Hill (Rowland Institute at Harvard)<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

                      Rapid multidimensional NMR using non-uniform samplingNon-Fourier spectral analysis, especially maximum entropy reconstructionRowland NMR Toolkit CollaboratorsAlan Stern (Rowland Institute at Harvard)Gerhard Wagner (Harvard Medical School)Mehdi Mobli (University of Queensland)Mark Maciejewski (UConn Health)Michael Gryk (UConn Health)Adam Schuyler (UConn Health)Jay Vyas (UConn Health)Jonathan Helmus (UConn Health)Matthew Fenwick (UConn Health) Coarse-grained modelingMoSART: Molecular Structure Analysis and Refinement ToolCollaborator:Alan Stern […]<\/p>\n","protected":false},"author":31,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"publishpress_future_action":{"enabled":false,"date":"2026-04-12 19:45:16","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/health.uconn.edu\/hoch-lab\/wp-json\/wp\/v2\/pages\/10"}],"collection":[{"href":"https:\/\/health.uconn.edu\/hoch-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/health.uconn.edu\/hoch-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/hoch-lab\/wp-json\/wp\/v2\/users\/31"}],"replies":[{"embeddable":true,"href":"https:\/\/health.uconn.edu\/hoch-lab\/wp-json\/wp\/v2\/comments?post=10"}],"version-history":[{"count":13,"href":"https:\/\/health.uconn.edu\/hoch-lab\/wp-json\/wp\/v2\/pages\/10\/revisions"}],"predecessor-version":[{"id":135,"href":"https:\/\/health.uconn.edu\/hoch-lab\/wp-json\/wp\/v2\/pages\/10\/revisions\/135"}],"wp:attachment":[{"href":"https:\/\/health.uconn.edu\/hoch-lab\/wp-json\/wp\/v2\/media?parent=10"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}